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Review article

Ecdysone biosynthesis: Pathways, enzymes, and the early steps problem

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Pages 91-99 | Published online: 25 Feb 2011

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J.-P. Roussel. (1992) Implication des 3-déhydroecdystéroïdes dans la voie de biosynthèse de l'ecdysone chez Locusta migratoria, in vitro. Archives Internationales de Physiologie, de Biochimie et de Biophysique 100:1, pages 45-53.
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WENDYA. SMITH & DIETER SEDLMEIER. (1990) Neurohormonal control of ecdysone production: Comparison of insects and crustaceans. Invertebrate Reproduction & Development 18:1-2, pages 77-89.
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Articles from other publishers (35)

An Liu, Wenyuan Shi, Dongdong Lin & Haihui Ye. (2021) A Possible Role of Allatostatin C in Inhibiting Ecdysone Biosynthesis Revealed in the Mud Crab Scylla paramamosain. Frontiers in Marine Science 8.
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R. Lafont, C. Dauphin-Villemant, J.T. Warren & H.H. Rees. 2017. Reference Module in Life Sciences. Reference Module in Life Sciences.
Rene Lafont, C. Dauphin-Villemant, J.T. Warren & H. Rees. 2012. Insect Endocrinology. Insect Endocrinology 106 176 .
Ryusuke Niwa, Toshiki Namiki, Katsuhiko Ito, Yuko Shimada-Niwa, Makoto Kiuchi, Shinpei Kawaoka, Takumi Kayukawa, Yutaka Banno, Yoshinori Fujimoto, Shuji Shigenobu, Satoru Kobayashi, Toru Shimada, Susumu Katsuma & Tetsuro Shinoda. (2010) Non-molting glossy / shroud encodes a short-chain dehydrogenase/reductase that functions in the ‘Black Box’ of the ecdysteroid biosynthesis pathway . Development 137:12, pages 1991-1999.
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James T. Warren, Michael B. O'Connor & Lawrence I. Gilbert. (2009) Studies on the black box: Incorporation of 3-oxo-7-dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta. Insect Biochemistry and Molecular Biology 39:10, pages 677-687.
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Reginaldo A. Festucci-BuselliLuis A. S. ContimLuiz Cláudio A. BarbosaJeff StuartWagner C. Otoni. (2008) Biosynthesis and potential functions of the ecdysteroid 20-hydroxyecdysone — a review. Botany 86:9, pages 978-987.
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R. Lafont, C. Dauphin–Villemant, J.T. Warren & H. Rees. 2005. Comprehensive Molecular Insect Science. Comprehensive Molecular Insect Science 125 195 .
Keiko Okuzumi, Noriyuki Hara, Yoshinori Fujimoto, Junko Yamada, Atsuko Nakamura, Kyoko Takahashi & Masuo Morisaki. (2003) Biosynthesis of phytoecdysteroids in Ajuga hairy roots: clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone. Tetrahedron Letters 44:2, pages 323-326.
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Lawrence I. GilbertRobert RybczynskiJames T. Warren. (2002) Control and Biochemical Nature of the Ecdysteroidogenic Pathway. Annual Review of Entomology 47:1, pages 883-916.
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James T Warren, Jasmine Wismar, Bhattiprolu Subrahmanyam & Lawrence I Gilbert. (2001) Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster. Molecular and Cellular Endocrinology 181:1-2, pages 1-14.
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Laurence Dinan. (2001) Phytoecdysteroids: biological aspects. Phytochemistry 57:3, pages 325-339.
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Yoshinori Fujimoto, Kiyoshi Ohyama, Keiko Nomura, Ryo Hyodo, Kyoko Takahashi, Junko Yamada & Masuo Morisaki. (2000) Biosynthesis of sterols and ecdysteroids in Ajuga hairy roots. Lipids 35:3, pages 279-288.
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Matthew Landau, William J. Biggers & Hans Laufer. 2011. Comprehensive Physiology. Comprehensive Physiology 1291 1390 .
Takayoshi Nakagawa, Noriyuki Hara & Yoshinori Fujimoto. (1997) Biosynthesis of 20-hydroxyecdysone in Ajuga hairy roots: Stereochemistry of C-25 hydroxylation. Tetrahedron Letters 38:15, pages 2701-2704.
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René Lafont. (1997) Ecdysteroids and related molecules in animals and plants. Archives of Insect Biochemistry and Physiology 35:1-2, pages 3-20.
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Jian-Hua Chen, Tracey J. Webb, Roy Powls & Huw H. Rees. (1996) Purification and Characterisation of Haemolymph 3-Dehydroecdysone 3beta-Reductase in Relation to Ecdysteroid Biosynthesis in the Cotton Leafworm Spodoptera littoralis. European Journal of Biochemistry 242:2, pages 394-401.
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James T. Warren, Jane S. Bachmann, Ji-Da Dai & Lawrence I. Gilbert. (1996) Differential incorporation of cholesterol and cholesterol derivatives into ecdysteroids by the larval ring glands and adult ovaries of Drosophila melanogaster: a putative explanation for the l(3)ecd1 mutation. Insect Biochemistry and Molecular Biology 26:8-9, pages 931-943.
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James T. Warren & Lawrence I. Gilbert. (1996) Metabolism in vitro of cholesterol and 25-hydroxycholesterol by the larval prothoracic glands of Manduca sexta. Insect Biochemistry and Molecular Biology 26:8-9, pages 917-929.
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Thomas J. Kelly, Belgaum S. Thyagaraja, Robert A. Bell & Edward P. Masler. (1995) A novel low molecular weight ecdysiotropin in post-diapause, pre-hatch eggs of the gypsy moth, Lymantria dispar L. (Lepidoptera: Lymantriidae). Regulatory Peptides 57:3, pages 253-261.
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Jaroslav Pis, Jean-Pierre Girault, Marc Larchevêque, Chantal Dauphin-Villemant & René Lafont. (1995) A convenient synthesis of 25-deoxyecdysone, a major secretory product of crustacean Y-organs and of 2,25-dideoxyecdysone, its putative immediate precursor. Steroids 60:2, pages 188-194.
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Mitsuhiro Nagakari, Tetsuo Kushiro, Takeshi Matsumoto, Nobukazu Tanaka, Katsumi Kakinuma & Yoshinori Fujimoto. (1994) Incorporation of acetate and cholesterol into 20-hydroxyecdysone by hairy root clone of Ajuga reptans var. Atropurpurea. Phytochemistry 36:4, pages 907-910.
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Robert Rybczynski & Lawrence I. Gilbert. (1994) Changes in general and specific protein synthesis that accompany ecdysteroid synthesis in stimulated prothoracic glands of Manduca sexta. Insect Biochemistry and Molecular Biology 24:2, pages 175-189.
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Michael L. Grieneisen. (1994) Recent advances in our knowledge of ecdysteroid biosynthesis in insects and crustaceans. Insect Biochemistry and Molecular Biology 24:2, pages 115-132.
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Michel Descamps & René Lafont. (1993) Conversion of different putative ecdysteroid precursors in Lithobius forficatus L. (Myriapoda: Chilopoda). Insect Biochemistry and Molecular Biology 23:4, pages 481-489.
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Frédéric Dolle, Charles Hetru, Bernard Rousseau, Frank Sobrio, Catherine Blais, René Lafont, Michel Descamp & Bang Luu. (1993) Synthesis of a tritiated 3-dehydroecdysteroid putative precursor of ecdysteroid biosynthesis. Tetrahedron 49:12, pages 2485-2498.
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M.L. Grieneisen, J.T. Warren & L.I. Gilbert. (1993) Early steps in ecdysteroid biosynthesis: Evidence for the involvement of cytochrome P-450 enzymes. Insect Biochemistry and Molecular Biology 23:1, pages 13-23.
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Evelyn Budd, Gerd Käuser & Jan Koolman. (2005) On the control of ecdysone biosynthesis by the central nervous system of blowfly larvae. Archives of Insect Biochemistry and Physiology 23:4, pages 181-197.
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Paul H. Rudolph & Eugene Spaziani. (1992) Formation of ecdysteroids by Y-organs of the crab, Menippe mercenaria. General and Comparative Endocrinology 88:2, pages 235-242.
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Paul H. Rudolph, Eugene Spaziani & Wenan L. Wang. (1992) Formation of ecdysteroids by Y-organs of the crab, Menippe mercenaria. General and Comparative Endocrinology 88:2, pages 224-234.
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H. -J. Bidmon, W. E. Stumpf & N. A. Granger. (1992) Ecdysteroid receptors in the neuroendocrine-endocrine axis of a moth. Experientia 48:1, pages 42-47.
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Hans-J. Bidmon. (1991) Developmental changes in the presence of ecdysteroid receptors in the central nervous system of third instar larvae of Sarcophaga bullata. Developmental Brain Research 63:1-2, pages 121-133.
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L. Swevers, J. G. D. Lambert & A. De Loof. (1991) Synthesis and metabolism of vertebrate-type steroids by tissues of insects: A critical evaluation. Experientia 47:7, pages 687-698.
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Rene Lafont. (1991) Reverse endocrinology, or “hormones” seeking functions. Insect Biochemistry 21:7, pages 697-721.
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M.L. Grieneisen, J.T. Warren, S. Sakurai & L.I. Gilbert. (1991) A putative route to ecdysteroids: Metabolism of cholesterol in vitro by mildly disrupted prothoracic glands of Manduca sexta. Insect Biochemistry 21:1, pages 41-51.
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Deborah A. Keightley, Kerin J. Lou & Wendy A. Smith. (1990) Involvement of translation and transcription in insect steroidogenesis. Molecular and Cellular Endocrinology 74:3, pages 229-237.
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