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Editorial

Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project

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Sverre E. Kjeldsen, Brent M. Egan, Krzysztof Narkiewicz, Reinhold Kreutz, Michel Burnier, Suzanne Oparil & Giuseppe Mancia. (2023) TIME to face the reality about evening dosing of antihypertensive drugs in hypertension. Blood Pressure 32:1, pages 1-3.
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Yong-Jian Geng, Michael H. Smolensky, Oliver Sum-Ping, Ramon Hermida & Richard J. Castriotta. (2023) Circadian rhythms of risk factors and management in atherosclerotic and hypertensive vascular disease: Modern chronobiological perspectives of an ancient disease. Chronobiology International 40:1, pages 33-62.
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Ramón C. Hermida, Artemio Mojón & José R. Fernández. (2020) Ambulatory blood pressure-based inclusion criteria in the Hygia Chronotherapy Trial. Rebuttal to Lemmer and Middeke. Chronobiology International 37:8, pages 1270-1272.
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Juan J. Crespo, Manuel Domínguez-Sardiña, Alfonso Otero, Ana Moyá, María T. Ríos, Elvira Sineiro, María C. Castiñeira, Pedro A. Callejas, Lorenzo Pousa, José L. Salgado, Carmen Durán, Juan J. Sánchez, Artemio Mojón, José R. Fernández & Ramón C. Hermida. (2020) Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials.. Chronobiology International 37:5, pages 771-780.
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Articles from other publishers (22)

Line Malha & William B. White. 2024. Hypertension. Hypertension 133 143 .
Ralph Wendt. (2023) Abendliche und morgendliche Einnahme von Antihypertensiva gleich wirksam und sicherEvening and morning use of antihypertensives equally effective and safe. Die Nephrologie 18:6, pages 397-399.
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Panagiota Anyfanti, Anastasia Malliora, Agapi Chionidou, Konstantinos Mastrogiannis, Antonios Lazaridis & Eugenia Gkaliagkousi. (2023) Clinical Significance of Nocturnal Hypertension and Nighttime Blood Pressure Dipping in Hypertension. Current Hypertension Reports.
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Edward J. Filippone, Andrew J. Foy & Gerald V. Naccarelli. (2023) Controversies in Hypertension III: Dipping, Nocturnal Hypertension, and the Morning Surge. The American Journal of Medicine 136:7, pages 629-637.
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Ruoning Chai, Zelin Ye, Qian Wu, Wenjing Xue, Shuqing Shi, Yihang Du, Huaqin Wu, Yi Wei & Yuanhui Hu. (2023) Circadian rhythm in cardiovascular diseases: a bibliometric analysis of the past, present, and future. European Journal of Medical Research 28:1.
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Michel Burnier & Aikaterini Damianaki. (2023) Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease. Circulation Research 132:8, pages 1050-1063.
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Teck K Khong. (2023) Putting night-time dosing of antihypertensives to bed for now. Drug and Therapeutics Bulletin 61:4, pages 50-50.
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Bridget M. Kuehn. (2023) No Benefit Seen for Nighttime Dosing Over Morning Dosing for Antihypertensive Medications. Circulation 147:6, pages 512-514.
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Chau Le Bao Ho & Christopher M. Reid. (2022) Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease. Exploration of Medicine 2:3, pages 461-467.
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George Stergiou, Mattias Brunström, Thomas MacDonald, Konstantinos G. Kyriakoulis, Michael Bursztyn, Nadia Khan, George Bakris, Anastasios Kollias, Ariadni Menti, Paul Muntner, Marcelo Orias, Neil Poulter, Daichi Shimbo, Bryan Williams, Abiodun Moshood Adeoye, Albertino Damasceno, Lyudmila Korostovtseva, Yan Li, Elizabeth Muxfeldt, Yuqing Zhang, Giuseppe Mancia, Reinhold Kreutz & Maciej Tomaszewski. (2022) Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension. Journal of Hypertension 40:10, pages 1847-1858.
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Edward J. Filippone, Andrew J. Foy & Gerald V. Naccarelli. (2022) Controversies in Hypertension I: The Optimal Assessment of Blood Pressure Load and Implications for Treatment. The American Journal of Medicine 135:9, pages 1043-1050.
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Iain J. McGurgan, Peter J. Kelly, Tanya N. Turan & Peter M. Rothwell. (2022) Long-Term Secondary Prevention: Management of Blood Pressure After a Transient Ischemic Attack or Stroke. Stroke 53:4, pages 1085-1103.
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Paolo Verdecchia, Claudio Cavallini & Fabio Angeli. (2022) Advances in the Treatment Strategies in Hypertension: Present and Future. Journal of Cardiovascular Development and Disease 9:3, pages 72.
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Christian Ott & Roland E. Schmieder. (2022) Diagnosis and treatment of arterial hypertension 2021. Kidney International 101:1, pages 36-46.
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Nicole P. Bowles & Steven A. Shea. (2021) Is the bedtime ingestion of hypertensive medications effective and safe?. Sleep Medicine Reviews 59, pages 101511.
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Ricky D. Turgeon, Andrew D. Althouse, Jordana B. CohenBogdan EnacheJohn B. HogeneschMichael E. JohansenRaj MehtaGideon Meyerowitz-Katz, Boback Ziaeian & Swapnil Hiremath. (2021) Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument. Hypertension 78:3, pages 871-878.
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Prossie Merab Ingabire, Dike B. Ojji, Brian Rayner, Elijah Ogola, Albertino Damasceno, Erika Jones, Anastase Dzudie, Okechukwu S. Ogah, Neil Poulter, Mahmoud U. Sani, Felix Ayub Barasa, Grace Shedul, John Mukisa, David Mukunya, Bonnie Wandera, Charles Batte, James Kayima, Shahiemah Pandie & Charles Kiiza Mondo. (2021) High prevalence of non-dipping patterns among Black Africans with uncontrolled hypertension: a secondary analysis of the CREOLE trial. BMC Cardiovascular Disorders 21:1.
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Chau L. B. Ho, Enayet K. Chowdhury, Jenny Doust, Mark R. Nelson & Christopher M. Reid. (2021) The effect of taking blood pressure lowering medication at night on cardiovascular disease risk. A systematic review. Journal of Human Hypertension 35:4, pages 308-314.
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Jessica R. Ivy & Matthew A. Bailey. (2021) Nondipping Blood Pressure: Predictive or Reactive Failure of Renal Sodium Handling?. Physiology 36:1, pages 21-34.
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Joseph T. Flynn. (2020) Kidney transplant patients don't dip on ambulatory blood pressure monitoring: What should be done about it?. Pediatric Transplantation 24:8.
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Christine B. Sethna, Lindsay G. Grossman, Preeta Dhanantwari, Shari Gurusinghe, Nina Laney, Rachel Frank & Kevin E. Meyers. (2020) Restoration of nocturnal blood pressure dip and reduction of nocturnal blood pressure with evening anti‐hypertensive medication administration in pediatric kidney transplant recipients: A pilot randomized clinical trial. Pediatric Transplantation 24:8.
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Reinhold Kreutz, Sverre E. Kjeldsen, Michel Burnier, Krzysztof Narkiewicz, Suzanne Oparil & Giuseppe Mancia. (2020) Disregard the reported data from the HYGIA project: blood pressure medication not to be routinely dosed at bedtime. Journal of Hypertension 38:11, pages 2144-2145.
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