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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 36, 2007 - Issue 2
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Alkylamides from Echinacea Modulate Induced Immune Responses in Macrophages

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Pages 117-130 | Published online: 07 Jul 2009

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M. Sharma, S. Vohra, J. T. Arnason & J. B. Hudson. (2008) Echinacea. Extracts Contain Significant and Selective Activities Against Human Pathogenic Bacteria. Pharmaceutical Biology 46:1-2, pages 111-116.
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Articles from other publishers (33)

Fahad Alharthi. (2023) Chicoric acid enhances the antioxidative defense system and protects against inflammation and apoptosis associated with the colitis model induced by dextran sulfate sodium in rats. Environmental Science and Pollution Research 30:57, pages 119814-119824.
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Sara F. Vieira, Samuel M. Gonçalves, Virgínia M. F. Gonçalves, Carmen P. Llaguno, Felipe Macías, Maria Elizabeth Tiritan, Cristina Cunha, Agostinho Carvalho, Rui L. Reis, Helena Ferreira & Nuno M. Neves. (2023) Echinacea purpurea Fractions Represent Promising Plant-Based Anti-Inflammatory Formulations. Antioxidants 12:2, pages 425.
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Leena Hussein Bajrai, Sherif Ali El-Kafrawy, Ahmed Mohamed Hassan, Ahmed Majdi Tolah, Rabie Saleh Alnahas, Sayed Sartaj Sohrab, Mohd Rehan & Esam Ibraheem Azhar. (2022) In vitro screening of anti-viral and virucidal effects against SARS-CoV-2 by Hypericum perforatum and Echinacea. Scientific Reports 12:1.
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Sara F. Vieira, Virgínia M. F. Gonçalves, Carmen P. Llaguno, Felipe Macías, Maria Elizabeth Tiritan, Rui L. Reis, Helena Ferreira & Nuno M. Neves. (2022) On the Bioactivity of Echinacea purpurea Extracts to Modulate the Production of Inflammatory Mediators. International Journal of Molecular Sciences 23:21, pages 13616.
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Cristina Burlou-Nagy, Florin Bănică, Tünde Jurca, Laura Grațiela Vicaș, Eleonora Marian, Mariana Eugenia Muresan, Ildikó Bácskay, Rita Kiss, Pálma Fehér & Annamaria Pallag. (2022) Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants 11:9, pages 1244.
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Monique Aucoin, Valentina Cardozo, Meagan D. McLaren, Anna Garber, Daniella Remy, Joy Baker, Adam Gratton, Mohammed Ali Kala, Sasha Monteiro, Cara Warder, Alessandra Perciballi & Kieran Cooley. (2021) A systematic review on the effects of Echinacea supplementation on cytokine levels: Is there a role in COVID-19?. Metabolism Open 11, pages 100115.
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Safa M. Shams Eldin, Eman Shawky, Shaimaa M. Sallam, Nefertiti El-Nikhely & Samah M. El Sohafy. (2021) Metabolomics approach provides new insights into the immunomodulatory discriminatory biomarkers of the herbs and roots of Echinacea species. Industrial Crops and Products 168, pages 113611.
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Rahul Sharma & Neelakantan Arumugam. (2021) N-alkylamides of Spilanthes (syn: Acmella): Structure, purification, characterization, biological activities and applications – a review. Future Foods 3, pages 100022.
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Ye PengQuancai SunYeonhwa Park. (2019) The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient. Journal of Medicinal Food 22:7, pages 645-652.
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Nicoletta De Rosa, Pierluigi Giampaolino, Giada Lavitola, Ilaria Morra, Carmen Formisano, Carmine Nappi & Giuseppe Bifulco. (2019) Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study. BioMed Research International 2019, pages 1-7.
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Bruce Barrett. 2018. Integrative Medicine. Integrative Medicine 170 179.e7 .
Aikun Fu, Yang Wang, Yanping Wu, Hongliang Chen, Shasha Zheng, Yali Li, Xin Xu & Weifen Li. (2017) Echinacea purpurea Extract Polarizes M1 Macrophages in Murine Bone Marrow-Derived Macrophages Through the Activation of JNK . Journal of Cellular Biochemistry 118:9, pages 2664-2671.
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Hannah Ayrle, Meike Mevissen, Martin Kaske, Heiko Nathues, Niels Gruetzner, Matthias Melzig & Michael Walkenhorst. (2016) Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review. BMC Veterinary Research 12:1.
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Jeanne Drisko & Kelly Kindscher. 2016. Echinacea. Echinacea 147 163 .
David J. Fast, John A. Balles, Jeffrey D. Scholten, Timothy Mulder & Jatinder Rana. (2015) Echinacea purpurea root extract inhibits TNF release in response to Pam3Csk4 in a phosphatidylinositol-3-kinase dependent manner. Cellular Immunology 297:2, pages 94-99.
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Yasamin Moazami, Travis V. Gulledge, Scott M. Laster & Joshua G. Pierce. (2015) Synthesis and biological evaluation of a series of fatty acid amides from Echinacea. Bioorganic & Medicinal Chemistry Letters 25:16, pages 3091-3094.
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. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 353 961 .
Maria O. Thomsen, Xavier C. Fretté, Kathrine B. Christensen, Lars P. Christensen & Kai Grevsen. (2012) Seasonal Variations in the Concentrations of Lipophilic Compounds and Phenolic Acids in the Roots of Echinacea purpurea and Echinacea pallida . Journal of Agricultural and Food Chemistry 60:49, pages 12131-12141.
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Jente Boonen, Antoon Bronselaer, Joachim Nielandt, Lieselotte Veryser, Guy De Tré & Bart De Spiegeleer. (2012) Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides. Journal of Ethnopharmacology 142:3, pages 563-590.
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James B. Hudson. (2012) Applications of the Phytomedicine Echinacea purpurea (Purple Coneflower) in Infectious Diseases . Journal of Biomedicine and Biotechnology 2012, pages 1-16.
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John Grbic, Isaiah Wexler, Romi Celenti, Jaclyn Altman & Aron Saffer. (2011) A phase II trial of a transmucosal herbal patch for the treatment of gingivitis. The Journal of the American Dental Association 142:10, pages 1168-1175.
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Nicholas J. Matovic, Patricia Y. Hayes, Kerry Penman, Reginald P. Lehmann & James J. De Voss. (2011) Polyunsaturated Alkyl Amides from Echinacea: Synthesis of Diynes, Enynes, and Dienes. The Journal of Organic Chemistry 76:11, pages 4467-4481.
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David S. SenchinaJennifer H. StrauchGriffin B. HoffmannNisarg B. ShahBrad K. LaflenBreanna L. DumkeChinh T. DaoAmila S. DiasM. Ann Perera. (2011) Phytochemical and Immunomodulatory Properties of an Echinacea laevigata (Asteraceae) Tincture . The Journal of Alternative and Complementary Medicine 17:4, pages 375-377.
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Nadja B. Cech, Vamsikrishna Kandhi, Jeanine M. Davis, Amy Hamilton, Dawn Eads & Scott M. Laster. (2010) Echinacea and its alkylamides: Effects on the influenza A-induced secretion of cytokines, chemokines, and PGE2 from RAW 264.7 macrophage-like cells. International Immunopharmacology 10:10, pages 1268-1278.
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Carlie A. LaLone, Nan Huang, Ludmila Rizshsky, Man-Yu Yum, Navrozedeep Singh, Cathy Hauck, Basil J. Nikolau, Eve S. Wurtele, Marian L. Kohut, Patricia A. Murphy & Diane F. Birt. (2010) Enrichment of Echinacea angustifolia with Bauer Alkylamide 11 and Bauer Ketone 23 Increased Anti-inflammatory Potential through Interference with COX-2 Enzyme Activity. Journal of Agricultural and Food Chemistry 58:15, pages 8573-8584.
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M. Sharma, R. Schoop & JB Hudson. (2010) The efficacy of Echinacea in a 3-D tissue model of human airway epithelium. Phytotherapy Research 24:6, pages 900-904.
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Gabriela Bomfim Ferreira, Chantal Mathieu & Lut Overbergh. (2010) Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling. PROTEOMICS - Clinical Applications 4:2, pages 190-203.
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J. Boonen, B. Baert, N. Roche, C. Burvenich & B. De Spiegeleer. (2010) Transdermal behaviour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts. Journal of Ethnopharmacology 127:1, pages 77-84.
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Chung Li Chen, Su Jean Chuang, Junne Jih Chen & Jih Min Sung. (2009) Using RAPD markers to predict polyphenol content in aerial parts of Echinacea purpurea plants . Journal of the Science of Food and Agriculture 89:12, pages 2137-2143.
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Andrea Chicca, Stefan Raduner, Federica Pellati, Thomas Strompen, Karl-Heinz Altmann, Roland Schoop & Jürg Gertsch. (2009) Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. International Immunopharmacology 9:7-8, pages 850-858.
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Zili Zhai, Avery Solco, Lankun Wu, Eve S. Wurtele, Marian L. Kohut, Patricia A. Murphy & Joan E. Cunnick. (2009) Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activation. Journal of Ethnopharmacology 122:1, pages 76-85.
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Chien-Yu Wang, Vanisree Staniforth, Ming-Tsang Chiao, Chia-Chung Hou, Han-Ming Wu, Kuo-Chen Yeh, Chun-Houh Chen, Pei-Ing Hwang, Tuan-Nan Wen, Lie-Fen Shyur & Ning-Sun Yang. (2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells. BMC Genomics 9:1.
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Anita Matthias, Linda Banbury, Kerry M. Bone, David N. Leach & Reg P. Lehmann. (2008) Echinacea alkylamides modulate induced immune responses in T-cells. Fitoterapia 79:1, pages 53-58.
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