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Seminars in Ophthalmology Volume 21, 2006 - Issue 3
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Research Article

Topical Medical Therapies for Ocular Surface Tumors

Antony M. Poothullil Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
&
Kathryn A. Colby Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Pages 161-169 | Published online: 02 Jul 2009

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Nefeli Eleni Kounatidou & Sotiria Palioura. (2021) An update in the management of ocular surface squamous neoplasia. Expert Review of Ophthalmology 16:4, pages 255-266.
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Oliver Niels Klefter, Marie Louise Roed Rasmussen, Peter Bjerre Toft & Steffen Heegaard. (2018) Therapeutic options for conjunctival neoplasia. Expert Review of Ophthalmology 13:1, pages 17-31.
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Michael Tsatsos & Carol L Karp. (2013) Modern management of ocular surface squamous neoplasia. Expert Review of Ophthalmology 8:3, pages 287-295.
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Carol L. Karp, Anat Galor, Yunhee Lee & Sonia H. Yoo. (2010) Pegylated Interferon Alpha 2b for Treatment of Ocular Surface Squamous Neoplasia: A Pilot Study. Ocular Immunology and Inflammation 18:4, pages 254-260.
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Jessica Ciralsky & Kathryn Colby. (2009) Conjunctival Melanomas: Can the Cancer Stem Cell Hypothesis be Applied?. Seminars in Ophthalmology 24:3, pages 161-165.
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Hossein Aghaei, Ahmad Kheirkhah, Ali Mohammad Alizadeh, Acieh Es’haghi, Roshanak Aliakbar-Navahi, Zahra Keikha & Samira Chaibakhsh. (2023) Local ocular safety of the subconjunctival injection of cetuximab in rabbits. BMC Ophthalmology 23:1.
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Simone Nuessle, Claudia Auw-Haedrich, Jana Jiang, Daniel Boehringer & Thomas Reinhard. (2022) Real-life data of adjuvant IFN-α2b and MMC in conjunctival melanocytic lesions. Graefe's Archive for Clinical and Experimental Ophthalmology 261:4, pages 1159-1166.
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Sinumol S. Thulaseedharan, Ajithkumar V Raghavan, Ashwati Sankar, N Sujatha, Sudha Vaikkakara & T Devu Krishna. (2023) Efficacy of topical immunotherapy in the management of Ocular Surface Squamous Neoplasia (OSSN)– A retrospective analysis. Kerala Journal of Ophthalmology 35:2, pages 141-148.
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K. S. Offer, F. Marchesi & D. G. M. Sutton. (2021) Topical 5‐fluorouracil as an adjunct treatment in equine corneolimbal squamous cell carcinoma. Equine Veterinary Education 34:9.
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Napaporn Tananuvat, Muanploy Niparugs, Damrong Wiwatwongwana, Nirush Lertprasertsuk & Pongsak Mahanupap. (2022) Ocular surface squamous neoplasia in Northern Thailand: a 16-year review. BMC Ophthalmology 22:1.
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Asim V. Farooq & Kathryn A. Colby. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 405 430 .
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Asim V. Farooq & Kathryn Colby. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 26 .
Richard R. Winkelmann, Tejas D. Desai, Maheera Farsi & Abel Torres. 2021. Skin Cancer Management. Skin Cancer Management 9 30 .
Nandini Venkateswaran, Carolina Mercado, Anat Galor & Carol L. Karp. (2019) Comparison of Topical 5-Fluorouracil and Interferon Alfa-2b as Primary Treatment Modalities for Ocular Surface Squamous Neoplasia. American Journal of Ophthalmology 199, pages 216-222.
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Manpreet Singh, Natasha Gautam & Manpreet Kaur. (2018) Role of topical interferon alpha-2b in ‘mitomycin-C-resistant’ ocular surface squamous neoplasia: our preliminary findings. International Ophthalmology 39:2, pages 295-301.
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NikhilS Gokhale. (2019) Severe necrotising inflammatory skin reaction to topical 5-fluorouracil. Indian Journal of Ophthalmology 67:12, pages 2066.
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Abbas Habibalahi, Alexandra Allende, Chandra Bala, Ayad G. Anwer, Subhas Mukhopadhyay & Ewa M. Goldys. (2019) Optimized Autofluorescence Spectral Signature for Non-Invasive Diagnostics of Ocular Surface Squamous Neoplasia (OSSN). IEEE Access 7, pages 141343-141351.
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Claudine Bellerive, Jesse L. Berry, Ashley Polski & Arun D. Singh. (2018) Conjunctival Squamous Neoplasia: Staging and Initial Treatment. Cornea 37:10, pages 1287-1291.
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Iku Kikuchi, Satoru Kase, Kan Ishijima & Susumu Ishida. (2017) Long-term follow-up of conjunctival melanoma treated with topical interferon alpha-2b eye drops as adjunctive therapy following surgical resection. Graefe's Archive for Clinical and Experimental Ophthalmology 255:11, pages 2271-2276.
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Raffaele Parrozzani, Luisa Frizziero, Sara Trainiti, Ilaria Testi, Giacomo Miglionico, Elisabetta Pilotto, Stella Blandamura, Ambrogio Fassina & Edoardo Midena. (2017) Topical 1% 5-fluoruracil as a sole treatment of corneoconjunctival ocular surface squamous neoplasia: long-term study. British Journal of Ophthalmology 101:8, pages 1094-1099.
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Im Gyu KimSung YuGwang Ja LeeKyoo Won LeeYoung Jeung Park. (2017) The Effectiveness of Topical Chemotherapy for the Primary Treatment of Ocular Surface Squamous Neoplasia. Journal of the Korean Ophthalmological Society 58:2, pages 147.
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Madhura G. Joag, Adam Sise, Juan Carlos Murillo, Ibrahim Osama Sayed-Ahmed, James R. Wong, Carolina Mercado, Anat Galor & Carol L. Karp. (2016) Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia. Ophthalmology 123:7, pages 1442-1448.
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Bindu Madhavi R, Soumya H.N & Ravi Prakash D. (2016) ROLE OF TOPICAL POSTOPERATIVE MITOMYCIN-C IN OCULAR SURFACE SQUAMOUS NEOPLASIA: A CASE REPORT. Journal of Evidence Based Medicine and Healthcare 3:26, pages 1205-1206.
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Swathi Kaliki, Swati Singh, Sadiya Iram & Dharani Tripuraneni. (2016) Recombinant interferon alpha 2b for ocular surface squamous neoplasia: An efficient and cost-effective treatment modality in Asian Indian patients. Indian Journal of Ophthalmology 64:10, pages 702.
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Bhavna Chawla, Rachna Seth & Laxmi Moksha. 2016. Pharmacology of Ocular Therapeutics. Pharmacology of Ocular Therapeutics 333 358 .
Kyeong Hwan Kim & Wan Soo Kim. (2015) Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1. Optometry and Vision Science 92:4S, pages S10-S13.
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SantoshG Honavar & FairoozP Manjandavida. (2015) Tumors of the ocular surface: A review. Indian Journal of Ophthalmology 63:3, pages 187.
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Rakhi Kusumesh, Anita Ambastha, Bibhuti Sinha & Rajiv Kumar. (2015) Topical Interferon α-2b as a Single Therapy for Primary Ocular Surface Squamous Neoplasia. Asia-Pacific Journal of Ophthalmology 4:5, pages 279-282.
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E. Mata, E. Conesa, M. Castro, L. Mart?nez, C. de Pablo & M.L. Gonz?lez. (2014) Conjunctival squamous cell carcinoma: paradoxical response to interferon eyedrops. Archivos de la Sociedad Espa?ola de Oftalmolog?a (English Edition) 89:7, pages 293-296.
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Bruno F. Fernandes, Katerina Nikolitch, James Coates, Gustavo Novais, Alexandre Odashiro, Patricia P. Odashiro, Rubens N. Belfort & Miguel N. BurnierJr.Jr.. (2014) Local chemotherapeutic agents for the treatment of ocular malignancies. Survey of Ophthalmology 59:1, pages 97-114.
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Benjamin J. Thomas, Anat Galor, Afshan A. Nanji, Fouad El Sayyad, Jianhua Wang, Sander R. Dubovy, Madhura G. Joag & Carol L. Karp. (2014) Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Diagnosis and Management of Ocular Surface Squamous Neoplasia. The Ocular Surface 12:1, pages 46-58.
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Carol L. Shields, Swathi Kaliki, H. Jane Kim, Saad Al-Dahmash, Sanket U. Shah, Sara E. Lally & Jerry A. Shields. (2013) Interferon for Ocular Surface Squamous Neoplasia in 81 Cases. Cornea 32:3, pages 248-256.
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Sean PaulDonald U. Stone. (2012) Intralesional Bevacizumab Use for Invasive Ocular Surface Squamous Neoplasia. Journal of Ocular Pharmacology and Therapeutics 28:6, pages 647-649.
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Tejas Desai, Cynthia L. Chen, Alpesh Desai & William Kirby. (2012) Basic Pharmacology of Topical Imiquimod, 5-Fluorouracil, and Diclofenac for the Dermatologic Surgeon. Dermatologic Surgery 38:1, pages 97-103.
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Andrés J. M. Ferreri, Riccardo Dolcetti, Silvia Govi & Maurilio Ponzoni. 2012. Bacteria and Cancer. Bacteria and Cancer 139 163 .
Rimvydas S. Asoklis, Aiste Damijonaityte, Laura Butkiene, Aimantas Makselis, Donatas Petroska, Mykolas Pajaujis & Grazina Juodkaite. (2018) Ocular Surface Reconstruction using Amniotic Membrane following Excision of Conjunctival and Limbal Tumors. European Journal of Ophthalmology 21:5, pages 552-558.
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Kathryn Colby, Pooja Bhat, Gustavo Novais & Frederick A Jakobiec. (2011) Recurrent Primary Acquired Melanosis With Atypia Involving a Clear Corneal Phacoemulsification Wound. Cornea 30:1, pages 114-116.
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Andrés J.M. Ferreri, Silvia Govi, Annalisa Colucci, Roberto Crocchiolo & Giulio Modorati. (2011) Intralesional Rituximab. Ophthalmology 118:1, pages 24-28.
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Carol L. Karp, Anat Galor, Sachin Chhabra, Scott D. Barnes & Eduardo C. Alfonso. (2010) Subconjunctival/Perilesional Recombinant Interferon α2b for Ocular Surface Squamous Neoplasia. Ophthalmology 117:12, pages 2241-2246.
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Surbhi Grover, Deborah S Jacobs & Kathryn A Colby. (2010) Boston Ocular Surface Prosthesis for Persistent Epitheliopathy After Treatment of Conjunctival Melanoma. Cornea 29:4, pages 459-461.
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Rebecca C Stacy, Kenneth R Kenyon, Frederick A Jakobiec & Kathryn A Colby. (2010) Conjunctival Melanoma Arising From Primary Acquired Melanosis in a Patient With Neurofibromatosis Type I. Cornea 29:2, pages 232-234.
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Kati-Sisko Vellonen, Eliisa Mannermaa, Helen Turner, Marika Häkli, J. Mario Wolosin, Timo Tervo, Paavo Honkakoski & Arto Urtti. (2010) Effluxing ABC transporters in human corneal epithelium. Journal of Pharmaceutical Sciences 99:2, pages 1087-1098.
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Tina Rike Herold & Christoph Hintschich. (2009) Interferon α for the treatment of melanocytic conjunctival lesions. Graefe's Archive for Clinical and Experimental Ophthalmology 248:1, pages 111-115.
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J.-P. Caujolle, C. Maschi, P. Chauvel, J. Herault & P. Gastaud. (2009) Association chirurgie-protonth?rapie dans le traitement des carcinomes invasifs et r?cidivants de la conjonctive?: technique et r?sultats pr?liminaires. Journal Fran?ais d'Ophtalmologie 32:10, pages 707-714.
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Adam K Rudkin & James S Muecke. (2009) Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations. Clinical & Experimental Ophthalmology 37:4, pages 352-356.
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Rola Hamam, Pooja Bhat & Charles Stephen Foster. (2009) Conjunctival/Corneal Intraepithelial Neoplasia. International Ophthalmology Clinics 49:1, pages 63-70.
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Abel Torres & Tejas Desai. 2010. Skin Cancer Management. Skin Cancer Management 9 26 .
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V. Huerva & I. Mangues. (2008) Treatment of conjunctival squamous neoplasias with interferon alpha 2b. Journal Français d'Ophtalmologie 31:3, pages 317-325.
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Devron H. Char & J. Brooks Crawford. (2008) Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma. Graefe's Archive for Clinical and Experimental Ophthalmology 246:3, pages 459-461.
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Mona Harissi-Dagher & Kathryn Colby. 2008. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology 789 804 .
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