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Original

Proliferative Vitreoretinopathy: Pathobiology and Therapeutic Targets

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Pages 62-69 | Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Khalil Ghasemi Falavarjani, Ali Hadavandkhani, Mohammad Mehdi Parvaresh, Mehdi Modarres, Masood Naseripour & Sayyed Amirpooya Alemzadeh. (2020) Intra-silicone Oil Injection of Methotrexate in Retinal Reattachment Surgery for Proliferative Vitreoretinopathy. Ocular Immunology and Inflammation 28:3, pages 513-516.
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Hsi-Kung Kuo, Yi-Hao Chen, Yu-Hsia Kuo, Mu-Chan Ke, Ya-chi Tseng & Pei-Chang Wu. (2018) Evaluation of the Effect of Everolimus on Retinal Pigment Epithelial Cells and Experimental Proliferative Vitreoretinopathy. Current Eye Research 43:3, pages 333-339.
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Jing Wang, Yin Liu, Zhongyuan Su, Li Pan, Fan Lu, Jia Qu & Ling Hou. (2017) The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium. Current Eye Research 42:11, pages 1537-1544.
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Ying Zheng, Philip Schindler, Vasyl Druchkiv, Jan Schulz, Stephan Martin Spitzer & Christos Skevas. (2023) Comparison of treatment outcomes of 360° intraoperative laser retinopexy and focal laser retinopexy with pars plans vitrectomy in patients with primary rhegmatogenous retinal detachment. BMC Ophthalmology 23:1.
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Soumaya Hachana & Bruno Larrivée. (2022) TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies. Cells 11:15, pages 2336.
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Priya R. Chandrasekaran & V. G. Madanagopalan. (2022) Role of Curcumin in Retinal Diseases—A review. Graefe's Archive for Clinical and Experimental Ophthalmology 260:5, pages 1457-1473.
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John H. Shen-Sampas, Tessnim R. Ahmad & Jay M. Stewart. (2022) Corneal Toxicity of Intravitreal Methotrexate Used for the Treatment of Proliferative Vitreoretinopathy in Silicone Oil-Filled Eyes: A Case Series. Cornea 41:4, pages 499-501.
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Xiaojuan Hu, Fang Li, Junhao He, Juan Yang, Ye Jiang, Mingyuan Jiang, Dandan Wei, Lifu Chang, J. Fielding Hejtmancik, Ling Hou & Xiaoyin Ma. (2021) LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control RPE Cell Proliferation . Investigative Opthalmology & Visual Science 62:14, pages 18.
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Annekatrin Rickmann, Andre Schulz, Bianca Bohrer, Maria Waizel, Lukas Bisorca-Gassendorf, Sami Al-Nawaiseh, Phillip Wakili & Kai Januschowski. (2021) Systemic Curcumin-Human Serum Albumin in Proliferative Vitreoretinal Retinopathy: A Pilot Study. Cureus.
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Ying Dai, Chenghua Dai & Tao Sun. (2020) Inflammatory mediators of proliferative vitreoretinopathy: hypothesis and review. International Ophthalmology 40:6, pages 1587-1601.
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Bing Liu, Jingyuan Song, Haote Han, Zhengping Hu, Na Chen, Jing Cui, Joanne Aiko Matsubara, Jingxiang Zhong & Hetian Lei. (2019) Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells. Laboratory Investigation 99:12, pages 1874-1886.
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Xiaoyin Ma, Huirong Li, Yu Chen, Juan Yang, Huaicheng Chen, Heinz Arnheiter & Ling Hou. (2019) The transcription factor MITF in RPE function and dysfunction. Progress in Retinal and Eye Research 73, pages 100766.
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Sana Idrees, Jayanth Sridhar & Ajay E. Kuriyan. (2019) Proliferative Vitreoretinopathy: A Review. International Ophthalmology Clinics 59:1, pages 221-240.
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Shigeo Yoshida, Yumi Umeno & Masatoshi Haruta. 2019. Periostin. Periostin 113 124 .
Yu-chen Lin, Ze-ren Shen, Xiao-hui Song, Xin Liu & Ke Yao. (2018) Comparative transcriptomic analysis reveals adriamycin-induced apoptosis via p53 signaling pathway in retinal pigment epithelial cells比较转录组学分析揭示阿霉素经p53信号通路诱导视网膜色素上皮细胞凋亡. Journal of Zhejiang University-SCIENCE B 19:12, pages 895-909.
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Khaled G. Abu Eleinen, Ahmed A. Mohalhal, Dalia A. Ghalwash, Ahmed A. Abdel-Kader, Ahmed A. Ghalwash, Islam A. Mohalhal & Abdussalam M. Abdullatif. (2018) Vitrectomy with scleral buckling versus with inferior retinectomy in treating primary rhegmatogenous retinal detachment with PVR and inferior breaks. Eye 32:12, pages 1839-1844.
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Jonathan Stone, John Mitrofanis, Daniel M. Johnstone, Benedetto Falsini, Silvia Bisti, Paul Adam, Arturo Bravo Nuevo, Mindy George-Weinstein, Rebecca Mason & Janis Eells. (2018) Acquired Resilience: An Evolved System of Tissue Protection in Mammals. Dose-Response 16:4, pages 155932581880342.
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Xiaoyin Ma, Jiajia Hua, Guoxiao Zheng, Fang Li, Chunbao Rao, Huirong Li, Jing Wang, Li Pan & Ling Hou. (2018) Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death-associated protein like-1 DAPL1 by alternative MITF splice forms. Pigment Cell & Melanoma Research 31:3, pages 411-422.
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Natalia Quiroz-CasianDavid Lozano-GiralAntonio Miranda-DuarteIvan Garcia-MontalvoJose L. Rodriguez-Loaiza & Juan C. Zenteno. (2018) ASSOCIATION STUDY BETWEEN POLYMORPHISMS OF THE p53 AND LYMPHOTOXIN ALPHA (LTA) GENES AND THE RISK OF PROLIFERATIVE VITREORETINOPATHY/RETINAL DETACHMENT IN A MEXICAN POPULATION. Retina 38:1, pages 187-191.
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Shigeo Yoshida, Takahito Nakama, Keijiro Ishikawa, Shintaro Nakao, Koh-hei Sonoda & Tatsuro Ishibashi. (2017) Periostin in vitreoretinal diseases. Cellular and Molecular Life Sciences 74:23, pages 4329-4337.
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Xiaoyin Ma, Huirong Li, Yipin Wang, Jing Wang, Qinxiang Zheng, Jiajia Hua, Juan Yang, Li Pan, Fan Lu, Jia Qu & Ling Hou. (2017) DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium. Human Molecular Genetics 26:9, pages 1612-1621.
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Hua He, Ajay E. Kuriyan, Chen-Wei Su, Megha Mahabole, Yuan Zhang, Ying-Ting Zhu, Harry W. Flynn, Jean-Marie Parel & Scheffer C. G. Tseng. (2017) Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3. Scientific Reports 7:1.
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Min Li, Hui Li, Xiaoqiang Liu, Ding Xu & Fang Wang. (2016) MicroRNA-29b regulates TGF-?1-mediated epithelial?mesenchymal transition of retinal pigment epithelial cells by targeting AKT2. Experimental Cell Research 345:2, pages 115-124.
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J. Carlos Pastor, Jimena Rojas, Salvador Pastor-Idoate, Salvatore Di Lauro, Lucia Gonzalez-Buendia & Santiago Delgado-Tirado. (2016) Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences. Progress in Retinal and Eye Research 51, pages 125-155.
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Gian Marco Tosi, Davide Marigliani, Napoleone Romeo & Paolo Toti. (2014) Disease Pathways in Proliferative Vitreoretinopathy: An Ongoing Challenge. Journal of Cellular Physiology 229:11, pages 1577-1583.
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YUN SUN & ZHI-PENG YOU. (2014) Curcumin inhibits human retinal pigment epithelial cell proliferation. International Journal of Molecular Medicine 34:4, pages 1013-1019.
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Marc Veckeneer, Kristel Maaijwee, David G Charteris & Jan C. van Meurs. (2014) Deferred laser photocoagulation of relaxing retinotomies under silicone oil tamponade to reduce recurrent macular detachment in severe proliferative vitreoretinopathy. Graefe's Archive for Clinical and Experimental Ophthalmology 252:10, pages 1539-1544.
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Min Li, Hui Li, Peng Jiang, Xiaoqiang Liu, Ding Xu & Fang Wang. (2014) Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis. Molecular BioSystems 10:5, pages 1055.
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Lei-Lei Wang, Yue Sun, Kun Huang & Ling Zheng. (2013) Curcumin, a potential therapeutic candidate for retinal diseases. Molecular Nutrition & Food Research 57:9, pages 1557-1568.
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Ryo Asato, Shigeo Yoshida, Atsushi Ogura, Takahito Nakama, Keijiro Ishikawa, Shintaro Nakao, Yukio Sassa, Hiroshi Enaida, Yuji Oshima, Kazuho Ikeo, Takashi Gojobori, Toshihiro Kono & Tatsuro Ishibashi. (2013) Comparison of Gene Expression Profile of Epiretinal Membranes Obtained from Eyes with Proliferative Vitreoretinopathy to That of Secondary Epiretinal Membranes. PLoS ONE 8:1, pages e54191.
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Claudio Azzolini, Ilaria Stefania Pagani, Cristina Pirrone, Davide Borroni, Simone Donati, Muna Al Oum, Diana Pigni, Anna Maria Chiaravalli, Riccardo Vinciguerra, Francesca Simonelli & Giovanni Porta. (2013) Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy. Mediators of Inflammation 2013, pages 1-8.
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Rachel M. Huckfeldt & Demetrios G. Vavvas. (2013) Neuroprotection for Retinal Detachment. International Ophthalmology Clinics 53:4, pages 105-117.
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Jin Ma, Tie Pei Zhu, Morten C. Moe, Panpan Ye & Ke Yao. (2012) Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation. Cytokine 59:1, pages 100-107.
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