Advanced search
Publication Cover
Seminars in Ophthalmology Volume 33, 2018 - Issue 1: Special Issue: Massachusetts Eye and Ear Infirmary
Submit an article Journal homepage
1,535
Views
47
CrossRef citations to date
0
Altmetric
Original Articles

Limbal Stem Cell Transplantation and Complications

Jia YinMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USACorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-1340-6758
ORCID Icon &
Ula JurkunasMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
, M.D.
Pages 134-141 | Published online: 27 Nov 2017

Citations (47)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Rajappa Senthilkumar, Hiroshi Yoshioka, Shojiro Katoh, Masaru Iwasaki, Vaddi Surya Prakash, Madasamy Balamurugan, Vidyasagar Devaprasad Dedeepiya, Senthilkumar Preethy & Samuel J. K. Abraham. (2023) Engraftment and Proliferation of Thermoreversible-Gelation-Polymer-Encapsulated Human Corneal Limbal-Stem-Cells on Ocular Surface of a Cadaver Cornea. Current Eye Research 48:6, pages 564-572.
Read now
Anahita Kate, Tanvi Mudgil & Sayan Basu. (2022) Longitudinal Changes in Corneal Epithelial Thickness and Reflectivity following Simple Limbal Epithelial Transplantation: An Optical Coherence Tomography-Based Study. Current Eye Research 47:3, pages 336-342.
Read now
Priyanshi Awasthi, Prabhakar Singh & Amit Raj. (2022) Surgical Management and Recent Advances in Chemical Injury: A 5-year Review. Seminars in Ophthalmology 37:1, pages 49-56.
Read now
C. Maya Tong, Bonnie He, Alfonso Iovieno & Sonia N. Yeung. (2021) Diagnosis and management of limbal stem cell deficiency, challenges, and future prospects. Expert Review of Ophthalmology 16:4, pages 305-318.
Read now
May Griffith, Bijay Kumar Poudel, Kamal Malhotra, Naoufal Akla, Miguel González-Andrades, David Courtman, Victor Hu & Emilio I. Alarcon. (2020) Biosynthetic alternatives for corneal transplant surgery. Expert Review of Ophthalmology 15:3, pages 129-143.
Read now
Dominique Bremond-Gignac, Henri Copin & Moncef Benkhalifa. (2018) Corneal epithelial stem cells for corneal injury. Expert Opinion on Biological Therapy 18:9, pages 997-1003.
Read now

Articles from other publishers (41)

Fatemeh Tavakkoli, Taher K Eleiwa, Abdelrahman M Elhusseiny, Mukesh Damala, Amit K Rai, Kasra Cheraqpour, Mohammad H Ansari, Mohammad Doroudian, Saeed H Keshel, Mohammad Soleimani, Ali R Djalilian, Virender S Sangwan & Vivek Singh. (2023) Corneal stem cells niche and homeostasis impacts in regenerative medicine; concise review. European Journal of Ophthalmology 33:4, pages 1536-1552.
Crossref
Lillian T. Tran & Jennifer Y. Li. (2023) The role of eye banking with cell-based therapies. Current Opinion in Ophthalmology 34:4, pages 334-338.
Crossref
Yingnan Zhang, Khoi K. Do, Fuhua Wang, Xiaoqin Lu, John Y. Liu, Chi Li, Brian P. Ceresa, Lijun Zhang, Douglas C. Dean & Yongqing Liu. (2023) Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility. Communications Biology 6:1.
Crossref
Yuan-Fang Zhu, Wen-Ya Qiu, Ye-Sheng Xu & Yu-Feng Yao. (2023) Clinical efficacy of a new surgical technique of oral mucosal epithelial transplantation for severe ocular surface disorders. BMC Ophthalmology 23:1.
Crossref
Gink N. Yang, Philippe Ke Roberts, Jesse Gardner-Russell, Manisha H. Shah, Terry A. Couper, Zhuoting Zhu, Graeme A. Pollock, Gregory J. Dusting & Mark Daniell. (2023) From bench to clinic: Emerging therapies for corneal scarring. Pharmacology & Therapeutics 242, pages 108349.
Crossref
Marta Cadenas-Martin, Francisco Arnalich-Montiel & Maria P De Miguel. (2023) Derivation of Limbal Stem Cells from Human Adult Mesenchymal Stem Cells for the Treatment of Limbal Stem Cell Deficiency. International Journal of Molecular Sciences 24:3, pages 2350.
Crossref
Kun Yi, Yuping Yang, Ye Yuan, Yingqian Xiang & Shanbi Zhou. (2022) Impaired Autophagy Causes Severe Corneal Neovascularization. Cells 11:23, pages 3895.
Crossref
Pei-Xi Ying, Min Fu, Chang Huang, Zhi-Hong Li, Qing-Yi Mao, Sheng Fu, Xu-Hui Jia, Yu-Chen Cao, Li-Bing Hong, Li-Yang Cai, Xi Guo, Ru-Bing Liu, Fan-ke Meng & Guo-Guo Yi. (2022) Profile of biological characterizations and clinical application of corneal stem/progenitor cells. World Journal of Stem Cells 14:11, pages 777-797.
Crossref
Anja Viestenz, Christiane Kesper, Thomas Hammer, Joana Heinzelmann, Sabine Foja & Arne Viestenz. (2022) ALT (allogeneic limbal transplantation): a new surgical technique for limbal stem cell deficiency. International Ophthalmology 42:12, pages 3749-3762.
Crossref
Ula Jurkunas, Lynette Johns & Myriam Armant. (2022) Cultivated Autologous Limbal Epithelial Cell Transplantation: New Frontier in the Treatment of Limbal Stem Cell Deficiency. American Journal of Ophthalmology 239, pages 244-268.
Crossref
Xiaoqin Zhang & Yu Wu. (2022) Acupoint Massage plus Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Limbal Stem Cell Transplantation on Visual Quality, Corneal Refraction, and Aesthetic Outcome in Patients with Pterygium. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-5.
Crossref
Abdelrahman M Elhusseiny, Mohammad Soleimani, Taher K Eleiwa, Reem H ElSheikh, Charles R Frank, Morteza Naderan, Ghasem Yazdanpanah, Mark I Rosenblatt & Ali R Djalilian. (2022) Current and Emerging Therapies for Limbal Stem Cell Deficiency. Stem Cells Translational Medicine 11:3, pages 259-268.
Crossref
Danni Gong, Chenxi Yan, Fei Yu, Dan Yan, Nianxuan Wu, Liangbo Chen, Siyi Zhang & Yao Fu. (2022) Direct oral mucosal epithelial transplantation supplies stem cells and promotes corneal wound healing to treat refractory persistent corneal epithelial defects. Experimental Eye Research 215, pages 108934.
Crossref
Katarzyna Krysik, Piotr Miklaszewski, Dariusz Dobrowolski, Anita Lyssek-Boroń, Beniamin O. Grabarek & Edward Wylęgała. (2021) Ocular Surface Preparation Before Keratoprosthesis Implantation. Ophthalmology and Therapy 11:1, pages 249-259.
Crossref
Emilio Valdivia, Marina Bertolin, Claudia Breda, Marco Carvalho Oliveira, Anna Katharina Salz, Nicola Hofmann, Martin Börgel, Rainer Blasczyk, Stefano Ferrari & Constanca Figueiredo. (2021) Genetic Modification of Limbal Stem Cells to Decrease Allogeneic Immune Responses. Frontiers in Immunology 12.
Crossref
Sadjad Khosravimelal, Mohammadmahdi Mobaraki, Samane Eftekhari, Mark Ahearne, Alexander Marcus Seifalian & Mazaher Gholipourmalekabadi. (2021) Hydrogels as Emerging Materials for Cornea Wound Healing. Small 17:30.
Crossref
Giovanni Miotti, Pier Camillo Parodi & Marco Zeppieri. (2021) Stem cell therapy in ocular pathologies in the past 20 years. World Journal of Stem Cells 13:5, pages 366-385.
Crossref
Sang Beom Han, Farah Nur Ilyana Mohd Ibrahim, Yu-Chi Liu & Jodhbir S. Mehta. (2021) Efficacy of Modified Amnion-Assisted Conjunctival Epithelial Redirection (ACER) for Partial Limbal Stem Cell Deficiency. Medicina 57:4, pages 369.
Crossref
Abhinav Reddy Kethiri, Vijay Kumar Singh, Mukesh Damala, Sayan Basu, Ch Mohan Rao, Kiran Kumar Bokara & Vivek Singh. (2021) Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery. Experimental Eye Research 205, pages 108526.
Crossref
In-Su Park, Byeong Kook Kim, Minh-Dung Truong, Hong Seok Yang, Sang-Hyug Park, Hyo Soon Park, Byung Hyune Choi, Bae Hie Won & Byoung-Hyun Min. (2021) Corneal Repair with Adhesive Cell Sheets of Fetal Cartilage-Derived Stem Cells. Tissue Engineering and Regenerative Medicine 18:1, pages 187-198.
Crossref
Mohd Tayyab Adil & Jonathan J. Henry. (2021) Understanding cornea epithelial stem cells and stem cell deficiency: Lessons learned using vertebrate model systems. genesis 59:1-2.
Crossref
Ali E. Ghareeb, Majlinda Lako & Francisco C. Figueiredo. (2020) Recent Advances in Stem Cell Therapy for Limbal Stem Cell Deficiency: A Narrative Review. Ophthalmology and Therapy 9:4, pages 809-831.
Crossref
Sophie X. Deng, Friedrich Kruse, José A. P. Gomes, Clara C. Chan, Sheraz Daya, Reza Dana, Francisco C. Figueiredo, Shigeru Kinoshita, Paolo Rama, Virender Sangwan, Allan R. Slomovic & Donald Tan. (2020) Global Consensus on the Management of Limbal Stem Cell Deficiency. Cornea 39:10, pages 1291-1302.
Crossref
Hamed Nosrati, Zahra Abpeikar, Zahra Gholami Mahmoudian, Mahdi Zafari, Jafar Majidi, Akram Alizadeh, Lida Moradi & Shiva Asadpour. (2020) Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface. Regenerative Medicine 15:8, pages 2029-2044.
Crossref
Kristina Krasner, Alexander Lykov, Maria Surovtseva, Valeriy Chernykh, Irina Kim, Alexander Trunov & Olga Poveshchenko. (2020) ReLEx SMILE Method to Expansion and Create Scaffolds from Corneal Fibroblasts. ReLEx SMILE Method to Expansion and Create Scaffolds from Corneal Fibroblasts.
Qihua Le, Tulika Chauhan, Madeline Yung, Chi-Hong Tseng & Sophie X. Deng. (2020) Outcomes of Limbal Stem Cell Transplant. JAMA Ophthalmology 138:6, pages 660.
Crossref
Lulu Hou, Wenbin Fu, Ying Liu, Qun Wang, Liqiang Wang & Yifei Huang. (2020) Agrin Promotes Limbal Stem Cell Proliferation and Corneal Wound Healing Through Hippo-Yap Signaling Pathway. Investigative Opthalmology & Visual Science 61:5, pages 7.
Crossref
Catherine J. Jackson, Inger T. Myklebust Ernø, Håkon Ringstad, Kim A. Tønseth, Darlene A. Dartt & Tor P. Utheim. (2020) Simple limbal epithelial transplantation: Current status and future perspectives. Stem Cells Translational Medicine 9:3, pages 316-327.
Crossref
Ovidiu Samoila & Diana Gocan. (2020) Clinical Outcomes From Cultivated Allogenic Stem Cells vs. Oral Mucosa Epithelial Transplants in Total Bilateral Stem Cells Deficiency. Frontiers in Medicine 7.
Crossref
Eman E. Taher, Mohamed Elalfy & Kareem Elsawah. 2020. Mesenchymal Stem Cells in Human Health and Diseases. Mesenchymal Stem Cells in Human Health and Diseases 45 78 .
Jing Zhu, Le-yi Wang, Chong-yun Li, Jia-yin Wu, Yu-ting Zhang, Kun-peng Pang, Yan Wei, Li-qun Du, Mei Liu & Xin-yi Wu. (2020) SPARC promotes self-renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38-MAPK signaling pathways. Stem Cells 38:1, pages 134-145.
Crossref
Mohammad Amir Mishan, Mehdi Yaseri, Alireza Baradaran-Rafii & Mozhgan Rezaei Kanavi. (2019) Systematic review and meta-analysis investigating autograft versus allograft cultivated limbal epithelial transplantation in limbal stem cell deficiency. International Ophthalmology 39:11, pages 2685-2696.
Crossref
Xiaolin Qi, Fangnan Duan, Xiang Li, Xiaoyu Zhang, Na Li, Mingna Liu & Hua Gao. (2019) Femtosecond Laser-Assisted Keratolimbal Allograft Transplantation for the Treatment of Total Limbal Stem Cell Deficiency. Cornea 38:10, pages 1280-1285.
Crossref
Medi Eslani, Albert Y. Cheung, Khaliq Kurji, Kasey Pierson, Enrica Sarnicola & Edward J. Holland. (2019) Long-term outcomes of conjunctival limbal autograft in patients with unilateral total limbal stem cell deficiency. The Ocular Surface 17:4, pages 670-674.
Crossref
Mukhtar Bizrah, Ammar Yusuf & Sajjad Ahmad. (2019) An update on chemical eye burns. Eye 33:9, pages 1362-1377.
Crossref
Brayden Barrientez, Sarah E. Nicholas, Amy Whelchel, Rabab Sharif, Jesper Hjortdal & Dimitrios Karamichos. (2019) Corneal injury: Clinical and molecular aspects. Experimental Eye Research 186, pages 107709.
Crossref
Gaëtan Le-Bel, Louis-Philippe Guérin, Patrick Carrier, Frédéric Mouriaux, Lucie Germain, Sylvain L. Guérin & Richard Bazin. (2019) Grafting of an autologous tissue-engineered human corneal epithelium to a patient with limbal stem cell deficiency (LSCD). American Journal of Ophthalmology Case Reports 15, pages 100532.
Crossref
Abhinav Reddy Kethiri, Enoch Raju, Kiran Kumar Bokara, Dilip Kumar Mishra, Sayan Basu, Ch Mohan Rao, Virender Singh Sangwan & Vivek Singh. (2019) Inflammation, vascularization and goblet cell differences in LSCD: Validating animal models of corneal alkali burns. Experimental Eye Research 185, pages 107665.
Crossref
O. A. Utheim, L. Pasovic, S. Raeder, J. R. Eidet, I. G. Fostad, A. Sehic, B. Roald, M. F. de la Paz, T. Lyberg, D. A. Dartt & T. P. Utheim. (2019) Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells. PLOS ONE 14:3, pages e0212524.
Crossref
Ghasem Yazdanpanah, Sayena Jabbehdari & Ali R. Djalilian. (2019) Emerging Approaches for Ocular Surface Regeneration. Current Ophthalmology Reports 7:1, pages 1-10.
Crossref
Nandini Venkateswaran & Guillermo Amescua. 2019. Corneal Regeneration. Corneal Regeneration 213 219 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.