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International Reviews of Immunology Volume 23, 2004 - Issue 3-4
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Research Article

DECREASED T CELL ERK PATHWAY SIGNALING MAY CONTRIBUTE TO THE DEVELOPMENT OF LUPUS THROUGH EFFECTS ON DNA METHYLATION AND GENE EXPRESSION

KURT OELKE Department of Medicine, University of Michigan, and the Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan
&
BRUCE RICHARDSON Department of Medicine, University of Michigan, and the Ann Arbor Veterans Affairs Hospital, Ann Arbor, MichiganCorrespondence[email protected]
Pages 315-331 | Published online: 03 Aug 2009

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W Lei, Y Luo, W Lei, Y Luo, K Yan, S Zhao, Y Li, X Qiu, Y Zhou, H Long, M Zhao, Y Liang, Y Su & Q Lu. (2009) Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scandinavian Journal of Rheumatology 38:5, pages 369-374.
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Faith M. Strickland & Bruce C. Richardson. (2008) Epigenetics in human autoimmunity. Autoimmunity 41:4, pages 278-286.
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Articles from other publishers (27)

Kerstin Klein. 2023. Handbook of Epigenetics. Handbook of Epigenetics 715 736 .
Dariusz Szukiewicz. (2022) Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity. Frontiers in Immunology 13.
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Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park & Soo Wan Kim. (2021) Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis. Journal of Nanobiotechnology 19:1.
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Youjin Li, Ji Zhou, Xiaoqing Rui, Lin Zhou & Xi Mo. (2019) PM2.5 exposure exacerbates allergic rhinitis in mice by increasing DNA methylation in the IFN-γ gene promoter in CD4+T cells via the ERK-DNMT pathway. Toxicology Letters 301, pages 98-107.
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Bruce Richardson. (2018) Reprint of "The interaction between environmental triggers and epigenetics in autoimmunity". Clinical Immunology 196, pages 72-76.
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Bruce Richardson. (2018) The interaction between environmental triggers and epigenetics in autoimmunity. Clinical Immunology 192, pages 1-5.
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Kerstin Klein, Hanna Maciejewska-Rodrigues, Steffen Gay & Astrid Jüngel. 2017. Handbook of Epigenetics. Handbook of Epigenetics 535 551 .
Christian Thomas & Sara Zapico. 2016. Mechanisms Linking Aging, Diseases and Biological Age Estimation. Mechanisms Linking Aging, Diseases and Biological Age Estimation 245 254 .
Ya-Chun Huang, Wen-Chun Hung, Wan-Tzu Chen, Hsin-Su Yu & Chee-Yin Chai. (2013) Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells. Toxicology Letters 220:2, pages 118-125.
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Faith M. Strickland, Anura Hewagama, Ailing Wu, Amr H. Sawalha, Colin Delaney, Mark F. Hoeltzel, Raymond Yung, Kent Johnson, Barbara Mickelson & Bruce C. Richardson. (2013) Diet Influences Expression of Autoimmune-Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus. Arthritis & Rheumatism 65:7, pages 1872-1881.
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Cliona M. O'Driscoll, Jonathan B. Coulter & Joseph P. Bressler. (2013) Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:3, pages 460-467.
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Zhenwu Lin, John P. Hegarty, Wei Yu, Jon A. Cappel, Xi Chen, Pieter W. Faber, Yunhua Wang, Lisa S. Poritz, Jian-Bing Fan & Walter A. Koltun. (2012) Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients. Digestive Diseases and Sciences 57:12, pages 3145-3153.
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Tanusree Sen, Nilkantha Sen, Maartje G. Noordhuis, Rajani Ravi, T-C Wu, Patrick K. Ha, David Sidransky & Mohammad Obaidul Hoque. (2012) OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB Function. PLoS ONE 7:11, pages e48770.
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Christopher Chang. 2012. Epigenetics in Human Disease. Epigenetics in Human Disease 225 251 .
Meiju Ji, Haixia Guan, Cuixia Gao, Bingyin Shi & Peng Hou. (2011) Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC). BMC Cancer 11:1.
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Christopher Chang & M. Eric Gershwin. (2011) Drug-Induced Lupus Erythematosus. Drug Safety 34:5, pages 357-374.
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Hanna Maciejewska-Rodrigues, Astrid Jüngel & Steffen Gay. 2011. Handbook of Epigenetics. Handbook of Epigenetics 535 551 .
Frank P Ryan. (2009) An alternative approach to medical genetics based on modern evolutionary biology. Part 5: epigenetics and genomics. Journal of the Royal Society of Medicine 102:12, pages 531-537.
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Ying Zhou, Jun Yuan, Yujun Pan, Yiping Fei, Xiangning Qiu, Nan Hu, Yongqi Luo, Wenzhi Lei, Yaping Li, Hai Long, Amr H Sawalha, Bruce Richardson & Qianjin Lu. (2009) T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus. Clinical Immunology 132:3, pages 362-370.
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Peng Hou, Meiju Ji & Mingzhao Xing. (2008) Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3‐kinase/AKT signaling pathway in thyroid tumors . Cancer 113:9, pages 2440-2447.
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S Gorjestani, V Rider, BF Kimler, C Greenwell & NI Abdou. (2008) Extracellular signal–regulated kinase 1/2 signalling in SLE T cells is influenced by oestrogen and disease activity. Lupus 17:6, pages 548-554.
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Xunrong Luo, Qiang Zhang, Victoria Liu, Zhenbiao Xia, Kathryn L. Pothoven & Chung Lee. (2008) Cutting Edge: TGF-β-Induced Expression of Foxp3 in T cells Is Mediated through Inactivation of ERK. The Journal of Immunology 180:5, pages 2757-2761.
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A. Monsiváis-Urenda, P. Niño-Moreno, C. Abud-Mendoza, L. Baranda, E. Layseca-Espinosa, M. López-Botet & R. González-Amaro. (2007) Analysis of expression and function of the inhibitory receptor ILT2 (CD85j/LILRB1/LIR-1) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE). Journal of Autoimmunity 29:2-3, pages 97-105.
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Dingxie Liu, Shuiying Hu, Peng Hou, David Jiang, Stephen Condouris & Mingzhao Xing. (2007) Suppression of BRAF/MEK/MAP Kinase Pathway Restores Expression of Iodide-Metabolizing Genes in Thyroid Cells Expressing the V600E BRAF Mutant. Clinical Cancer Research 13:4, pages 1341-1349.
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Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Alma Chavez-Blanco, Alma Revilla-Vazquez, Luis Benitez-Bribiesca & Alfonso Duenas-González. (2006) Global DNA hypermethylation-associated cancer chemotherapy resistance and its reversion with the demethylating agent hydralazine. Journal of Translational Medicine 4:1.
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Addison A. Taylor & James L. Pool. (2005) Clinical Pharmacology of Antihypertensive Therapy. Seminars in Nephrology 25:4, pages 215-226.
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Ana M. Blasini & Martín A. Rodríguez. 2005. Molecular Autoimmunity. Molecular Autoimmunity 245 261 .

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