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Special Topic: CpG Motifs

Immune Mechanisms and Therapeutic Potential of CpG Oligodeoxynucleotides

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Pages 183-213 | Published online: 03 Aug 2009

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Wenqiang Chen, Mingxia Jiang, Wenjing Yu, Zhiwei Xu, Xinyue Liu, Qingmiao Jia, Xiuwen Guan & Weifen Zhang. (2021) CpG-Based Nanovaccines for Cancer Immunotherapy. International Journal of Nanomedicine 16, pages 5281-5299.
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Anju Manuja, Balvinder K. Manuja, Jyoti Kaushik, Harisankar Singha & Raj Kumar Singh. (2013) Immunotherapeutic potential of CpG oligodeoxynucleotides in veterinary species. Immunopharmacology and Immunotoxicology 35:5, pages 535-544.
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Reto Crameri. (2007) Allergy vaccines: dreams and reality. Expert Review of Vaccines 6:6, pages 991-999.
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Ziad Thotathil & Michael B Jameson. (2007) Early experience with novel immunomodulators for cancer treatment. Expert Opinion on Investigational Drugs 16:9, pages 1391-1403.
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Yuting Su, Xiaojie Li, Ka Lung Lam & Peter C.K. Cheung. (2020) pH-sensitive PEG-coated hyper-branched β-d-glucan derivative as carrier for CpG oligodeoxynucleotide delivery. Carbohydrate Polymers 246, pages 116621.
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Floriane Auderset, Marie Ballester, Beatris Mastelic-Gavillet, Paola Fontannaz, Martine Chabaud-Riou, Nathalie Reveneau, Marie Garinot, Noëlle Mistretta, Yuanqing Liu, Paul-Henri Lambert, Martina Ochs & Claire-Anne Siegrist. (2019) Reactivating Immunity Primed by Acellular Pertussis Vaccines in the Absence of Circulating Antibodies: Enhanced Bacterial Control by TLR9 Rather Than TLR4 Agonist-Including Formulation. Frontiers in Immunology 10.
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Chunhui Wu, Xiaotian Guan, Jiming Xu, Yingxue Zhang, Qiuyue Liu, Yuan Tian, Shun Li, Xiang Qin, Hong Yang & Yiyao Liu. (2019) Highly efficient cascading synergy of cancer photo-immunotherapy enabled by engineered graphene quantum dots/photosensitizer/CpG oligonucleotides hybrid nanotheranostics. Biomaterials 205, pages 106-119.
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Astia Sanjaya, Jacob R. Elder & Devendra H. Shah. (2017) Identification of new CpG oligodeoxynucleotide motifs that induce expression of interleukin-1β and nitric oxide in avian macrophages. Veterinary Immunology and Immunopathology 192, pages 1-7.
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Jeong Hyun Cho, Hyo-Ji Lee, Hyun-Jeong Ko, Byung-Il Yoon, Jongseon Choe, Keun-Cheol Kim, Tae-Wook Hahn, Jeong A. Han, Sun Shim Choi, Young Mee Jung, Kee-Ho Lee, Yun-Sil Lee & Yu-Jin Jung. (2017) The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma. Oncotarget 8:15, pages 24932-24948.
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Huijie Zhang & Xiao-Dong Gao. (2017) Nanodelivery systems for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides. Materials Science and Engineering: C 70, pages 935-946.
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Glen N. Barber. (2011) Cytoplasmic DNA innate immune pathways. Immunological Reviews 243:1, pages 99-108.
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Glen N Barber. (2011) Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Current Opinion in Immunology 23:1, pages 10-20.
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Qing Cheng, Zhenggu Jiang, Chenchao Xu, Huazhou Li, Ding Cao, Zhaihan Yang, Guangjun Cao & Zhang Linghua. (2010) CpG oligodeoxynucleotide promotes protective immunity in the enteric mucosa and suppresses enterotoxigenic E. coli in the weaning piglets. International Immunopharmacology 10:10, pages 1249-1260.
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Yan Han, Mingshan Niu, Lijia An & Wenli Li. (2009) Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-κB pathways. International Immunopharmacology 9:7-8, pages 817-823.
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Deidra A. Blanks & Charles S. EbertJrJr. (2008) Immune modulatory oligonucleotides in the prevention and treatment of allergen-induced eustachian tube dysfunction in the animal model. Current Allergy and Asthma Reports 8:6.
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Tong Liu, Jessica Nerren, Jennifer Murrell, Veronique Juillard, Hanane El Garch, Ronald Martens & Noah Cohen. (2008) CpG-Induced Stimulation of Cytokine Expression by Peripheral Blood Mononuclear Cells of Foals and Their Dams. Journal of Equine Veterinary Science 28:7, pages 419-426.
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Arshud Dar, Anil K. Nichani, Ponn Benjamin, Ken Lai, Henry Soita, Arthur M. Krieg, Andrew Potter, Lorne A. Babiuk & George K. Mutwiri. (2008) Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNα-producing cells and TLR9 mRNA expression. Veterinary Immunology and Immunopathology 123:3-4, pages 324-336.
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Anna Luganini, Patrizia Caposio, Santo Landolfo & Giorgio Gribaudo. (2008) Phosphorothioate-Modified Oligodeoxynucleotides Inhibit Human Cytomegalovirus Replication by Blocking Virus Entry. Antimicrobial Agents and Chemotherapy 52:3, pages 1111-1120.
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E. G. Marazuela, N. Prado, E. Moro, H. Fernández-García, M. Villalba, R. Rodríguez & E. Batanero. (2008) Intranasal vaccination with poly(lactide-co-glycolide) microparticles containing a peptide T of Ole e 1 prevents mice against sensitization. Clinical & Experimental Allergy 38:3, pages 520-528.
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Satoshi Yotsumoto, Kazuharu Saegusa & Yukihiko Aramaki. (2008) Endosomal Translocation of CpG-Oligodeoxynucleotides Inhibits DNA-PKcs-Dependent IL-10 Production in Macrophages. The Journal of Immunology 180:2, pages 809-816.
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Laurel J. Gershwin. 2008. Clinical Biochemistry of Domestic Animals. Clinical Biochemistry of Domestic Animals 157 172 .
Deidra A Blanks. (2007) Immunostimulatory sequences in immunotherapy. Current Opinion in Otolaryngology & Head and Neck Surgery 15:4, pages 281-285.
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Haiqi He, Kenneth J. Genovese, Christina L. Swaggerty, David J. Nisbet & Michael H. Kogut. (2007) In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG oligodeoxynucleotides. Veterinary Immunology and Immunopathology 117:3-4, pages 275-283.
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Marion Jurk & Jörg Vollmer. (2007) Therapeutic Applications of Synthetic CpG Oligodeoxynucleotides as TLR9 Agonists for Immune Modulation. BioDrugs 21:6, pages 387-401.
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A.M. Lopez, R. Hecker, G. Mutwiri, S. van Drunen Littel-van den Hurk, L.A. Babiuk & H.G.G. Townsend. (2006) Formulation with CpG ODN enhances antibody responses to an equine influenza virus vaccine. Veterinary Immunology and Immunopathology 114:1-2, pages 103-110.
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