Advanced search
Publication Cover
International Reviews of Immunology Volume 27, 2008 - Issue 3
Submit an article Journal homepage
862
Views
69
CrossRef citations to date
0
Altmetric
Original

Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections

Hiroshi Terunuma Biotherapy Institute of Japan, Tokyo, Japan; Tokyo Clinic Marunouchi Oazo mc, Tokyo, Japan; Southern Tohoku Research Institute for Neuroscience, Fukushima, Japan
,
Xuewen Deng Biotherapy Institute of Japan, Tokyo, Japan
,
Zahidunnabi Dewan AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan
,
Shigeyoshi Fujimoto Biotherapy Institute of Japan, Tokyo, Japan
&
Naoki Yamamoto AIDS Research Center, National Institute of Infectious Disease, Tokyo, Japan
Pages 93-110 | Published online: 03 Aug 2009

Citations (69)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Senthilkumar Preethy, Vidyasagar Devaprasad Dedeepiya, Rajappa Senthilkumar, Mathaiyan Rajmohan, Ramalingam Karthick, Hiroshi Terunuma & Samuel J. K. Abraham. (2017) Natural killer cells as a promising tool to tackle cancer—A review of sources, methodologies, and potentials. International Reviews of Immunology 36:4, pages 220-232.
Read now
Sophie Templer & Gavin Sacks. (2016) A blessing and a curse: is high NK cell activity good for health and bad for reproduction?. Human Fertility 19:3, pages 166-172.
Read now

Articles from other publishers (67)

Hongwei Jiang & Jingting Jiang. (2023) Balancing act: the complex role of NK cells in immune regulation. Frontiers in Immunology 14.
Crossref
Elena Muraro & Giulia Brisotto. 2023. Circulating Tumor Cells, From Biotech Innovation to Clinical Utility. Circulating Tumor Cells, From Biotech Innovation to Clinical Utility 131 157 .
Xuewen Deng & Hiroshi Terunuma. (2022) Harnessing NK Cells to Control Metastasis. Vaccines 10:12, pages 2018.
Crossref
Seung-U Son, Han Wool Kim, Min Seung Park & Kwang-Soon Shin. (2022) Effects of intravenous administration of polysaccharide purified from fermented barley on tumor metastasis inhibition via immunostimulating activities. Food Bioscience 49, pages 101833.
Crossref
Hoang-Phuong Nguyen, Duc-Anh Dao Pham, Duy Dinh Nguyen, Phong Van Nguyen, Viet-Anh Bui, My-Nhung Thi Hoang & Liem Thanh Nguyen. (2022) Evaluating the Safety and Quality of Life of Colorectal Cancer Patients Treated by Autologous Immune Enhancement Therapy (AIET) in Vinmec International Hospitals. International Journal of Molecular Sciences 23:19, pages 11362.
Crossref
Xuewen Deng, Hiroshi Terunuma & Mie Nieda. (2022) Exploring the Utility of NK Cells in COVID-19. Biomedicines 10:5, pages 1002.
Crossref
Ahmed F. Elsaid, Sudhanshu Agrawal, Anshu Agrawal & Mamdooh Ghoneum. (2021) Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial. Nutrients 13:11, pages 4133.
Crossref
Elisa C. Toffoli, Abdolkarim Sheikhi, Roeland Lameris, Lisa A. King, Amanda van Vliet, Bruce Walcheck, Henk M. W. Verheul, Jan Spanholtz, Jurriaan Tuynman, Tanja D. de Gruijl & Hans J. van der Vliet. (2021) Enhancement of NK Cell Antitumor Effector Functions Using a Bispecific Single Domain Antibody Targeting CD16 and the Epidermal Growth Factor Receptor. Cancers 13:21, pages 5446.
Crossref
Marisa Market, Gayashan Tennakoon & Rebecca C. Auer. (2021) Postoperative Natural Killer Cell Dysfunction: The Prime Suspect in the Case of Metastasis Following Curative Cancer Surgery. International Journal of Molecular Sciences 22:21, pages 11378.
Crossref
Seung-U Son, Ho Young Park, Hyung Joo Suh & Kwang-Soon Shin. (2021) Evaluation of antitumor metastasis via immunostimulating activities of pectic polysaccharides isolated from radish leaves. Journal of Functional Foods 85, pages 104639.
Crossref
Li-Jie Hsu, Chao-Lin Liu, Ming-Ling Kuo, Chia-Ning Shen & Chia-Rui Shen. (2021) An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells. Biomedicines 9:10, pages 1323.
Crossref
Xuewen Deng, Hiroshi Terunuma & Mie Nieda. (2021) Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging. Biomedicines 9:5, pages 557.
Crossref
Yaoyao Shi, Katarzyna Tomczak, June Li, Joshua K. Ochieng, Younghee Lee & Cara Haymaker. (2021) Next-Generation Immunotherapies to Improve Anticancer Immunity. Frontiers in Pharmacology 11.
Crossref
Ping Gong, Yifan Wang, Pengfei Zhang, Zhaogang Yang, Weiye Deng, Zhihong Sun, Mingming Yang, Xuefeng Li, Gongcheng Ma, Guanjun Deng, Shiyan Dong, Lintao Cai & Wen Jiang. (2020) Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy. Cancers 13:1, pages 77.
Crossref
Henrik Pierre Calum, Claus Moser, Peter Ostrup Jensen, Thomas Bjarnsholt, Michael Givskov & Niels Høiby. (2020) Early IL‐2 treatment of mice with Pseudomonas aeruginosa pneumonia induced PMN‐dominating response and reduced lung pathology . APMIS 128:12, pages 647-653.
Crossref
Ashish O. Gupta & John E. Wagner. (2020) Umbilical Cord Blood Transplants: Current Status and Evolving Therapies. Frontiers in Pediatrics 8.
Crossref
Sushma K. CribbsKristina CrothersAlison Morris. (2020) Pathogenesis of HIV-Related Lung Disease: Immunity, Infection, and Inflammation. Physiological Reviews 100:2, pages 603-632.
Crossref
Jürgen Arnhold. 2020. Cell and Tissue Destruction. Cell and Tissue Destruction 155 203 .
Maryam Ebadi, Mohammad Amin Sadeghi, Nishitha M. Reddy & Nima Rezaei. 2020. Cancer Immunology. Cancer Immunology 159 212 .
Nguyen Thanh Liem, Nguyen Van Phong, Nguyen Trung Kien, Bui Viet Anh, Truong Linh Huyen, Chu Thi Thao, Nguyen Dac Tu, Doan Trung Hiep, Do Thi Hoai Thu & Hoang Thi My Nhung. (2019) Phase I Clinical Trial Using Autologous Ex Vivo Expanded NK Cells and Cytotoxic T Lymphocytes for Cancer Treatment in Vietnam. International Journal of Molecular Sciences 20:13, pages 3166.
Crossref
Robinson F. Alvarez, José A.M. Barbuto & Roberto Venegeroles. (2019) A nonlinear mathematical model of cell-mediated immune response for tumor phenotypic heterogeneity. Journal of Theoretical Biology 471, pages 42-50.
Crossref
Rose Nabatanzi, Lois Bayigga, Stephen Cose, Sarah Rowland-Jones, Glenda Canderan, Moses Joloba & Damalie Nakanjako. (2019) Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort. Clinical Immunology 201, pages 55-60.
Crossref
Nicholas Rhoades, Norma Mendoza, Allen Jankeel, Suhas Sureshchandra, Alexander D. Alvarez, Brianna Doratt, Omeid Heidari, Rod Hagan, Brandon Brown, Steven Scheibel, Theodore Marbley, Jeff Taylor & Ilhem Messaoudi. (2019) Altered Immunity and Microbial Dysbiosis in Aged Individuals With Long-Term Controlled HIV Infection. Frontiers in Immunology 10.
Crossref
Tomasz Jodlowski & K. H. Ramesh. 2019. Molecular Diagnostics in Cancer Patients. Molecular Diagnostics in Cancer Patients 237 268 .
Marisa Market, Katherine Baxter, Leonard Angka, Michael Kennedy & Rebecca Auer. (2018) The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction. Cancers 11:1, pages 2.
Crossref
Rose Nabatanzi, Stephen Cose, Moses Joloba, Sarah Rowland Jones & Damalie Nakanjako. (2018) Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells. AIDS Research and Therapy 15:1.
Crossref
Z Li, S Richards, H K Surks, A Jacobs & M A Panzara. (2018) Clinical pharmacology of alemtuzumab, an anti-CD52 immunomodulator, in multiple sclerosis. Clinical and Experimental Immunology 194:3, pages 295-314.
Crossref
F. Rajabi, L.A. DrakeM.M. SennaN. Rezaei. (2018) Alopecia areata: a review of disease pathogenesis. British Journal of Dermatology 179:5, pages 1033-1048.
Crossref
Longhui Zhang, Yuetao Zhao, Ying Dai, Jia-Nan Cheng, Zhihua Gong, Yi Feng, Chengdu Sun, Qingzhu Jia & Bo Zhu. (2018) Immune Landscape of Colorectal Cancer Tumor Microenvironment from Different Primary Tumor Location. Frontiers in Immunology 9.
Crossref
Lisa M. Fleischer, Rachana D. Somaiya & Gregory M. Miller. (2018) Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers. Frontiers in Pharmacology 9.
Crossref
Sue Jung Lee, Ho Sung Lee, Sun Young Kim & Kwang-Soon Shin. (2018) Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry. Carbohydrate Polymers 181, pages 911-917.
Crossref
Ranganathan Chidambaram, Hiroshi Terunuma, Madasamy Balamurugan, Vidyasagar Devaprasad Dedeepiya, Premkumar Sumana, Rajappa Senthilkumar, Mathaiyan Rajmohan, Ramalingam Karthick, Senthilkumar Preethy & Samuel J.K. Abraham. (2017) Cell-based immunotherapy in stage IIIA inflammatory breast cancer with declining innate immunity following successive chemotherapies: A case report. Molecular and Clinical Oncology 7:3, pages 493-497.
Crossref
Mahdi Mahmoudi, Faranak Fallahian, Soheila Sobhani, Shima Ghoroghi, Ahmadreza Jamshidi, Shiva Poursani, Masoumeh Dolati, Zahra Hosseinpour & Farhad Gharibdoost. (2017) Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis. Clinical Rheumatology 36:4, pages 853-862.
Crossref
Juanjuan Yi, Cuilin Cheng, Xiaoyu Li, Haitian Zhao, Hang Qu, Zhenyu Wang & Lu Wang. (2017) Protective mechanisms of purified polyphenols from pinecones of Pinus koraiensis on spleen tissues in tumor-bearing S180 mice in vivo. Food & Function 8:1, pages 151-166.
Crossref
Liat Sorski, Rivka Melamed, Pini Matzner, Hagar Lavon, Lee Shaashua, Ella Rosenne & Shamgar Ben-Eliyahu. (2016) Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition. Brain, Behavior, and Immunity 58, pages 91-98.
Crossref
Ting-Hua Yang, Chung-Hong Hu & Hsiou-Hsin Tsai. (2016) Pyoderma gangrenosum preceding the onset of extranodal natural killer/T-cell lymphoma. Medicine 95:40, pages e4997.
Crossref
Cheol-Hun Son, Hong-Rae Lee, Eun-Kyoung Koh, Dong-Yeok Shin, Jae-Ho Bae, Kwangmo Yang & You-Soo Park. (2016) Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells. Scientific Reports 6:1.
Crossref
Mengyun Ke, Hui Wang, Yiran Zhou, Jingwen Li, Yang Liu, Min Zhang, Jie Dou, Tao Xi, Baiyong Shen & Changlin Zhou. (2016) SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice . Oncotarget 7:31, pages 49509-49526.
Crossref
Hiroshi Terunuma, Noriyuki Nishino, Tsuyoshi Abe, Akiko Yoshimura, Atsushi Toki, Tatsuaki Ishiguro, Xuewen Deng & Atsushi Terunuma. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 309 318 .
Hiroshi Terunuma. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 127 135 .
Katrina M. Morris, Marina Mathew, Courtney Waugh, Beata Ujvari, Peter Timms, Adam Polkinghorne & Katherine Belov. (2015) Identification, characterisation and expression analysis of natural killer receptor genes in Chlamydia pecorum infected koalas (Phascolarctos cinereus). BMC Genomics 16:1.
Crossref
GA RIM KIM, GA-HEE HA, JAE-HO BAE, SAE-OCK OH, SUN-HEE KIM & CHI-DUG KANG. (2015) Metastatic colon cancer cell populations contain more cancer stem-like cells with a higher susceptibility to natural killer cell-mediated lysis compared with primary colon cancer cells. Oncology Letters 9:4, pages 1641-1646.
Crossref
Maryam Ebadi, Nishitha M. Reddy & Nima Rezaei. 2015. Cancer Immunology. Cancer Immunology 135 183 .
Lothar Rink, Andrea Kruse & Hajo HaaseHajo Haase. 2015. Immunologie für Einsteiger. Immunologie für Einsteiger 167 174 .
Samuel J. K. Abraham, Hiroshi Terunuma, Vidyasagar Devaprasad Dedeepiya, Sumana Premkumar & Senthilkumar Preethy. 2015. International Manual of Oncology Practice. International Manual of Oncology Practice 933 953 .
Xuewen Deng, Hiroshi Terunuma, Atsushi Terunuma, Tsubasa Takane & Mie Nieda. (2014) Ex vivo-expanded natural killer cells kill cancer cells more effectively than ex vivo-expanded γδ T cells or αβ T cells. International Immunopharmacology 22:2, pages 486-491.
Crossref
Dae-Joon Kim, Seong-Hoon Park, Jung-Chul Seo, Kyung Soon Kim, Ki Cheul Sohn, Im Hee Shin & Hun Mo Ryoo. (2014) Efficacy of Saam acupuncture treatment on improvement of immune cell numbers in cancer patients: a pilot study. Journal of Traditional Chinese Medicine 34:5, pages 550-554.
Crossref
BASKAR SUBRAMANI, CHITHRA RAMANATHAN PULLAI, KOHILA KRISHNAN, SHEELA DEVI SUGADAN, XUEWEN DENG, TERUNUMA HIROSHI & KANANATHAN RATNAVELU. (2014) Efficacy of ex vivo activated and expanded natural killer cells and T lymphocytes for colorectal cancer patients. Biomedical Reports 2:4, pages 505-508.
Crossref
Xiuying Li, Yongsheng Wang, Yuwei Zhao, Hengxiu Yang, Aiping Tong, Chengjian Zhao, Huashan Shi, Yang Li, Zhenlin Wang & Yuquan Wei. (2013) Immunotherapy of tumor with vaccine based on basic fibroblast growth factor-activated fibroblasts. Journal of Cancer Research and Clinical Oncology 140:2, pages 271-280.
Crossref
Animesh Barua, Michael J. Bradaric, Pincas Bitterman, Jacques S. Abramowicz, Sameer Sharma, Sanjib Basu, Heather Lopez & Janice M. Bahr. (2013) Dietary Supplementation of Ashwagandha ( Withania somnifera , Dunal) Enhances NK Cell Function in Ovarian Tumors in the Laying Hen Model of Spontaneous Ovarian Cancer . American Journal of Reproductive Immunology 70:6, pages 538-550.
Crossref
Lyudmila G. BurdelyaCraig M. BrackettBojidar KojouharovIlya I. GitlinKaterina I. LeonovaAnatoli S. GleibermanSemra Aygun-SunarJean VeithChristopher JohnsonGary J. HaderskiPatricia Stanhope-BakerShyam AllamaneniJoseph SkitzkiMing Zeng, Elena Martsen, Alexander Medvedev, Dmitry Scheblyakov, Nataliya M. Artemicheva, Denis Y. Logunov, Alexander L. Gintsburg, Boris S. Naroditsky, Sergei S. Makarov & Andrei V. Gudkov. (2013) Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist. Proceedings of the National Academy of Sciences 110:20.
Crossref
BASKAR SUBRAMANI, KANANATHAN RATNAVELU, CHITHRA RAMANATHAN PULLAI, KOHILA KRISHNAN, SHEELA DEVI SUGADAN, XUEWEN DENG & TERUNUMA HIROSHI. (2013) Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncology Letters 5:5, pages 1611-1614.
Crossref
Hui Peng, Rui Sun, Ling Tang, Haiming Wei & Zhigang Tian. (2013) CD62L Is Critical for Maturation and Accumulation of Murine Hepatic NK Cells in Response to Viral Infection. The Journal of Immunology 190:8, pages 4255-4262.
Crossref
Xuewen Deng, Hiroshi Terunuma, Mie Nieda, Weihua Xiao & Andrew Nicol. (2012) Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. International Immunopharmacology 14:4, pages 593-605.
Crossref
María P. Roberti, Yamila S. Rocca, Mora Amat, María B. Pampena, José Loza, Federico Coló, Verónica Fabiano, Carlos M. Loza, Juan M. Arriaga, Michele Bianchini, María M. Barrio, Alicia I. Bravo, Enzo Domenichini, Reinaldo Chacón, José Mordoh & Estrella M. Levy. (2012) IL-2- or IL-15-activated NK cells enhance Cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients. Breast Cancer Research and Treatment 136:3, pages 659-671.
Crossref
Christoph Stein, Ingo Schubert & Georg H. Fey. (2012) Natural Killer (NK)- and T-Cell Engaging Antibody-Derived Therapeutics. Antibodies 1:1, pages 88-123.
Crossref
VIDYASAGAR DEVAPRASAD DEDEEPIYA, HIROSHI TERUNUMA, XUEWEN DENG, SUBRAMANI BASKAR, SADANANDA RAO MANJUNATH, RAJAPPA SENTHILKUMAR, PALANISAMY MURUGAN, PARAMASIVAM THAMARAIKANNAN, THANGAVELU SRINIVASAN, SENTHILKUMAR PREETHY & SAMUEL J.K. ABRAHAM. (2012) A comparative analysis of in vitro expansion of natural killer cells of a patient with autoimmune haemolytic anaemia and ovarian cancer with patients with other solid tumours. Oncology Letters 3:2, pages 435-440.
Crossref
Lothar Rink, Andrea Kruse & Hajo HaaseLothar Rink, Andrea Kruse & Hajo Haase. 2012. Immunologie für Einsteiger. Immunologie für Einsteiger 201 209 .
M. P. Roberti, M. M. Barrio, A. I. Bravo, Y. S. Rocca, J. M. Arriaga, M. Bianchini, J. Mordoh & E. M. Levy. (2011) IL-15 and IL-2 increase Cetuximab-mediated cellular cytotoxicity against triple negative breast cancer cell lines expressing EGFR. Breast Cancer Research and Treatment 130:2, pages 465-475.
Crossref
Estrella Mariel Levy, María Paula Roberti & José Mordoh. (2011) Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications. Journal of Biomedicine and Biotechnology 2011, pages 1-11.
Crossref
Masahiro Takada, Hiroshi Terunuma, Xuewen Deng, Md. Zahidunnabi Dewan, Shigehira Saji, Katsumasa Kuroi, Naoki Yamamoto & Masakazu Toi. (2010) Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach. Breast Cancer 18:1, pages 64-67.
Crossref
Timothy L. Frankel, William Burns, John Riley, Richard A. Morgan, Jeremy L. Davis, Kenichi Hanada, Martha Quezado, Steven A. Rosenberg & Richard E. Royal. (2010) Identification and characterization of a tumor infiltrating CD56+/CD16− NK cell subset with specificity for pancreatic and prostate cancer cell lines. Cancer Immunology, Immunotherapy 59:12, pages 1757-1769.
Crossref
Azizul Haque, Mitzi Nagarkatti, Prakash Nagarkatti, Naren L. Banik & Swapan K. Ray. 2010. Glioblastoma. Glioblastoma 365 397 .
Md. Zahidunnabi Dewan, Masahiro Takada, Hiroshi Terunuma, Xuewen Deng, Sunjida Ahmed, Naoki Yamamoto & Masakazu Toi. (2009) Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients. Biomedicine & Pharmacotherapy 63:9, pages 703-706.
Crossref
Manutsanun Sumonwiriya, Navin Horhthongkham, Kovit Pattanapanyasat, Silawun Ampol, Reungpung Sutthent & Wannee Kantakamalakul. (2009) Stable expression of EBV-gp350 on the surface of NC37 cells confers natural killer (NK)-cell susceptibility or resistance, depending on the assay used to assess NK-mediated function. Journal of Virological Methods 161:1, pages 154-160.
Crossref
T. Sutlu & E. Alici. (2009) Natural killer cell-based immunotherapy in cancer: current insights and future prospects. Journal of Internal Medicine 266:2, pages 154-181.
Crossref
Lisbeth BarkholtMarco Bregni. (2009) Current immunotherapy for solid tumors. Immunotherapy 1:3, pages 483-493.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.