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Fibroblast-like synoviocytes-dependent effector molecules as a critical mediator for rheumatoid arthritis: Current status and future directions

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Pages 20-30 | Received 20 May 2016, Accepted 02 Dec 2016, Published online: 19 Jan 2017

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Guanhua Song, Qiqi Lu, Hua Fan, Xiumei Zhang, Luna Ge, Ruisong Tian, Shiguan Wang, Tingting Feng, Jihong Pan, Jingjing Feng, Yabo Xiao, Xin Yi, Ningxin Ren & Lin Wang. (2019) Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis. Arthritis Research & Therapy 21:1.
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Feng Gao & Xin Li. (2019) P2Y11 receptor antagonist NF340 ameliorates inflammation in human fibroblast‐like synoviocytes: An implication in rheumatoid arthritis. IUBMB Life 71:10, pages 1552-1560.
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Kübra Bunte & Thomas Beikler. (2019) Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases. International Journal of Molecular Sciences 20:14, pages 3394.
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Yanjie Ding, Qing Zhao & Laifang Wang. (2019) Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes. Chemico-Biological Interactions 306, pages 131-137.
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Ramamoorthi Ganesan & Mahaboobkhan Rasool. (2018) Ferulic acid inhibits interleukin 17‐dependent expression of nodal pathogenic mediators in fibroblast‐like synoviocytes of rheumatoid arthritis. Journal of Cellular Biochemistry 120:2, pages 1878-1893.
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Lei Zhang, Jun Yu, Chun Wang & Wei Wei. (2019) The effects of total glucosides of paeony (TGP) and paeoniflorin (Pae) on inflammatory-immune responses in rheumatoid arthritis (RA). Functional Plant Biology 46:2, pages 107.
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Yan Wang, Li Dai, Hong Wu, Zheng-rong Zhang, Wen-yu Wang, Jun Fu, Ran Deng, Feng Li, Xue-jing Dai & Xiang Zhan. (2018) Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts. International Immunopharmacology 65, pages 284-294.
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Guoqing Li, Zhongbing Xia, Ying Liu, Fanru Meng, Xia Wu, Yuxuan Fang, Chunwang Zhang & Dan Liu. (2018) SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway. Bioscience Reports 38:3.
Crossref
Sen-Wei Tsai, Ming-Chia Hsieh, Shiming Li, Shih-Chao Lin, Shun-Ping Wang, Caitlin Lehman, Christopher Lien & Chi-Chien Lin. (2018) Therapeutic Potential of Sclareol in Experimental Models of Rheumatoid Arthritis. International Journal of Molecular Sciences 19:5, pages 1351.
Crossref
Tianbao Lu, Ming Zong, Shasha Fan, Ying Lu, Shanhan Yu & Lieying Fan. (2017) Thioredoxin 1 is associated with the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes. Clinical Rheumatology 37:1, pages 117-125.
Crossref
Pravin Shende, Bernice Rodrigues & R. S. Gaud. 2018. Cell Biology and Translational Medicine, Volume 2. Cell Biology and Translational Medicine, Volume 2 59 72 .
Ramamoorthi Ganesan & Mahaboobkhan Rasool. (2017) Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis. Molecular Immunology 91, pages 134-144.
Crossref
Bharati Matta, Su Song, Dan Li & Betsy J. Barnes. (2017) Interferon regulatory factor signaling in autoimmune disease. Cytokine 98, pages 15-26.
Crossref

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