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Triggering receptor expressed on myeloid cells-1 (TREM-1) as a therapeutic target in infectious and noninfectious disease: a critical review

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Pages 188-202 | Received 23 Dec 2019, Accepted 23 Apr 2020, Published online: 07 May 2020

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Lyudmila Turgunova, Irina Mekhantseva, Lyudmila Akhmaltdinova, Mikhail Kostinov, Zhibek Zhumadilova & Anar Turmukhambetova. (2023) Association of sTREM‐1 and Neutrophil-to-Lymphocyte Ratio as Prognostic Markers in COVID-19 Short- and Long-Term Mortality. Journal of Inflammation Research 16, pages 5807-5817.
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Dervis Ates, Hulusi Cem Doner, Sevil Kurban & Hande Koksal. (2022) The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis. Immunological Investigations 51:4, pages 839-850.
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Harbinder Singh, Vikrant Rai, Sunil K. Nooti & Devendra K. Agrawal. (2021) Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates. Expert Opinion on Therapeutic Patents 31:6, pages 549-561.
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Articles from other publishers (15)

Tudorita Gabriela Paranga, Mariana Pavel-Tanasa, Daniela Constantinescu, Claudia Elena Plesca, Cristina Petrovici, Ionela-Larisa Miftode, Mihaela Moscalu, Petru Cianga & Egidia Gabriela Miftode. (2023) Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants. Frontiers in Immunology 14.
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Xiaoman Liu, Mingxia Zhou, Zhenzhen Dai, Shangjian Luo, Yingying Shi, Zhenjuan He & Yingwei Chen. (2022) Salidroside alleviates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis‐associated Th17/Treg imbalance. Phytotherapy Research 37:2, pages 367-382.
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Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, Mike Telemaco Contreras Colmenares, Geraldo Rodrigues Sartori, Marcelle Silva-Sales, João Herminio Martins Da Silva, Bruno Junior Neves, Carolina Horta Andrade & Helioswilton Sales-Campos. (2023) The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization. Computational and Structural Biotechnology Journal 21, pages 2579-2590.
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Patrick H. Dessein, Anne E. Stanwix & Ahmed Solomon. (2022) How Could Physical Activity Reduce Inflammation and Inflammatory Gene Expression in Rheumatoid Arthritis?. The Journal of Rheumatology 49:12, pages 1299-1302.
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Anastasios Panagopoulos, Saurabhi Samant, Jules Joel Bakhos, Martin Liu, Behram Khan, Janaki Makadia, Fayaz Muhammad, Forrest M. Kievit, Devendra K. Agrawal & Yiannis S. Chatzizisis. (2022) Triggering receptor expressed on myeloid cells-1 (TREM-1) inhibition in atherosclerosis. Pharmacology & Therapeutics 238, pages 108182.
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Bing Wei & Yingmin Ma. (2022) Synergistic effect of GF9 and streptomycin on relieving gram-negative bacteria-induced sepsis. Frontiers in Bioengineering and Biotechnology 10.
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Chenyang Chang, Qiannan Gao, Guoping Deng, Kaiyuan Luo & Huifang Zhu. (2022) Diagnostic and prognostic predictive values of triggering receptor expressed on myeloid cell-1 expression in neonatal sepsis: A meta-analysis and systematic review. Frontiers in Pediatrics 10.
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Sara Siskind, Max Brenner & Ping Wang. (2022) TREM-1 Modulation Strategies for Sepsis. Frontiers in Immunology 13.
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Tatiana N. Sharapova, Olga K. Ivanova, Elena A. Romanova, Lidia P. Sashchenko & Denis V. Yashin. (2022) N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor. International Journal of Molecular Sciences 23:10, pages 5752.
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Sagar Dholariya, Deepak N. Parchwani, Ragini Singh, Madhuri Radadiya & C. D. S. Katoch. (2021) Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection. Indian Journal of Clinical Biochemistry 37:2, pages 131-138.
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Pedro V. da Silva-Neto, Jonatan C. S. de Carvalho, Vinícius E. Pimentel, Malena M. Pérez, Diana M. Toro, Thais F. C. Fraga-Silva, Carlos A. Fuzo, Camilla N. S. Oliveira, Lilian C. Rodrigues, Jamille G. M. Argolo, Ingryd Carmona-Garcia, Nicola T. Neto, Camila O. S. Souza, Talita M. Fernandes, Victor A. F. Bastos, Augusto M. Degiovani, Leticia F. Constant, Fátima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, Fernando C. Vilar, Gilberto G. Gaspar, José J. R. da Rocha, Omar Feres, Fabiani G. Frantz, Raquel F. Gerlach, Sandra R. Maruyama, Elisa M. S. Russo, Angelina L. Viana, Ana P. M. Fernandes, Isabel K. F. M. Santos, Vânia L. D. Bonato, Antonio L. Boechat, Adriana Malheiro, Ruxana T. Sadikot, Marcelo Dias-Baruffi, Cristina R. B. Cardoso, Lúcia H. Faccioli & Carlos A. Sorgi. (2021) sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity. Viruses 13:12, pages 2521.
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Ferhan Kerget, Buğra Kerget, Sibel İba Yılmaz & Ahmet Kızıltunç. (2021) Evaluation of the relationship between TREM‐1/TREM‐2 ratio and clinical course in COVID‐19 pneumonia. International Journal of Clinical Practice 75:10.
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Jyun-Bin Huang, Nai-Ching Chen, Chien-Liang Chen, Mu-Hui Fu, Hsiu-Yung Pan, Chung-Yao Hsu, Shang-Der Chen & Yao-Chung Chuang. (2020) Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 Associated with the Severity and Outcome of Acute Ischemic Stroke. Journal of Clinical Medicine 10:1, pages 61.
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Federica Raggi & Maria Bosco. (2020) Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1). Cancers 12:5, pages 1337.
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Xiangyang Wei, Liting Hu, Guibo Liu, Xiaoni Yin, Ning Duan, Qinghua Li, Ying Li, Guiqiu Zhao & Zhaodong Du. (2022) Inhibition of TREM-1 Alleviates Choroidal Neovascularization in a Mouse Model. SSRN Electronic Journal.
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