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Original Article

The Putative Role of Fibroblasts in the Pathogenesis of Graves' Disease: Evidence for the Involvement of the Insulin-like Growth Factor-1 Receptor in Fibroblast Activation

Pages 409-415 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Shu-Hong Chang & Raymond S Douglas. (2010) Novel ways to attack inflammation in thyroid eye disease. Expert Review of Ophthalmology 5:3, pages 277-281.
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Ramzi A Ajjan & Anthony P Weetman. (2006) New insights into antibody-mediated hyperthyroidism. Expert Review of Endocrinology & Metabolism 1:1, pages 67-81.
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Articles from other publishers (48)

Balik Dzhambazov, Tsvetelina Batsalova, Patrick Merky, Franziska Lange & Rikard Holmdahl. (2023) NIH/3T3 Fibroblasts Selectively Activate T Cells Specific for Posttranslationally Modified Collagen Type II. International Journal of Molecular Sciences 24:13, pages 10811.
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Michelangelo P Reyes, John Cabrera, Jasvir Singh & Dennis Turnbull. (2023) Teprotumumab for Treatment of Pretibial Myxedema. JCEM Case Reports 1:1.
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Ricaurte Crespo-Trevino, Jade Schiffman, Shoaib Ugradar, Kimberly Cockerham, Raymond Douglas, David de Leon-Garza & Rosa Tang. (2022) Thyroid dermopathy responds to teprotumumab therapy. Endocrinology, Diabetes & Metabolism Case Reports 2022.
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Perparim Cerri, Bushra Shahida, Mikael Lantz & Tereza Planck. (2022) Serum CYR61 Levels are Associated with Graves’ Ophthalmopathy and Smoking in Patients with Graves’ Disease. Hormone and Metabolic Research 54:03, pages 168-174.
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Jingxin Xin, Wencong Cheng, Yongbing Yu, Juan Chen, Xinhuan Zhang & Shanshan Shao. (2022) Diosgenin From Dioscorea Nipponica Rhizoma Against Graves’ Disease—On Network Pharmacology and Experimental Evaluation. Frontiers in Pharmacology 12.
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Chrysoula Dosiou & Andrea Lora Kossler. (2021) Thyroid Eye Disease: Navigating the New Treatment Landscape. Journal of the Endocrine Society 5:5.
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Anaïs L. Carniciu & Alon Kahana. 2021. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery 983 999 .
Yazhuo Huang, Sijie Fang, Shuo Zhang & Huifang Zhou. (2020) Progress in the pathogenesis of thyroid-associated ophthalmopathy and new drug development. Taiwan Journal of Ophthalmology 10:3, pages 174.
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Dominika Łacheta, Piotr Miśkiewicz, Alicja Głuszko, Grażyna Nowicka, Maria Struga, Ireneusz Kantor, Krzysztof B. Poślednik, Shafaq Mirza & Mirosław J. Szczepański. (2019) Immunological Aspects of Graves’ Ophthalmopathy. BioMed Research International 2019, pages 1-12.
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Christine M. Longo & Paul J. Higgins. (2019) Molecular biomarkers of Graves' ophthalmopathy. Experimental and Molecular Pathology 106, pages 1-6.
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R. A. Ajjan & A. P. Weetman. 2018. Thyroid Diseases. Thyroid Diseases 57 87 .
Praveen Devarbhavi, Animesh Maiti, Diana Fernandes, Anirban Sinha, Asish Kumar Basu, Satyam Chakraborty, Lakshmi Dey, Subir Swar & Kingshuk Bhattacharjee. (2017) Rituximab therapy in steroid resistant thyroid associated ophthalmopathy. Case Reports International 6:1, pages 1-4.
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Thuy L. Phung, Teresa S. Wright, Crystal Y. Pourciau & Bruce R. SmollerThuy L. Phung, Teresa S. Wright, Crystal Y. Pourciau & Bruce R. Smoller. 2017. Pediatric Dermatopathology. Pediatric Dermatopathology 317 345 .
R. A. Ajjan & A. P. Weetman. 2016. Thyroid Diseases. Thyroid Diseases 1 31 .
Seema KumarMichael CoenenSeethalakshmi IyerRebecca S. Bahn. (2015) Forkhead Transcription Factor FOXO1 Is Regulated by Both a Stimulatory Thyrotropin Receptor Antibody and Insulin-Like Growth Factor-1 in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy. Thyroid 25:10, pages 1145-1150.
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J. P. Banga, S. Moshkelgosha, U. Berchner-Pfannschmidt & A. Eckstein. (2015) Modeling Graves’ Orbitopathy in Experimental Graves’ Disease. Hormone and Metabolic Research 47:10, pages 797-803.
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Jie Shen, Zhangfang Li, Wenting Li, Ying Ge, Min Xie, Meng Lv, Yanfei Fan, Zhi Chen, Defu Zhao & Yajuan Han. (2015) Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy. Disease Markers 2015, pages 1-6.
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Daniel Weil & Guillermo A. Fridrich. 2015. Orbital Tumors. Orbital Tumors 371 378 .
Tereza PlanckBushra ShahidaHemang ParikhKristoffer StrömPeter ÅsmanHåkan BrorsonBengt HallengrenMikael Lantz. (2014) Smoking Induces Overexpression of Immediate Early Genes in Active Graves' Ophthalmopathy. Thyroid 24:10, pages 1524-1532.
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He Li, Caroline Fitchett, Katarzyna Kozdon, Hari Jayaram, Geoffrey E. Rose, Maryse Bailly & Daniel G. Ezra. (2014) Independent Adipogenic and Contractile Properties of Fibroblasts in Graves’ Orbitopathy: An In Vitro Model for the Evaluation of Treatments. PLoS ONE 9:4, pages e95586.
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Aimee J. Varewijck, Anita Boelen, Steven W. J. Lamberts, Eric Fliers, Leo J. Hofland, Wilmar M. Wiersinga & Joseph A. M. J. L. Janssen. (2013) Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy. The Journal of Clinical Endocrinology & Metabolism 98:2, pages 769-776.
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Pingqian Zhao, Yuan Deng, Ping Gu, Yefei Wang, Huifang Zhou, Yamin Hu, Ping Chen & Xianqun Fan. (2013) Insulin-like growth factor 1 promotes the proliferation and adipogenesis of orbital adipose-derived stromal cells in thyroid-associated ophthalmopathy. Experimental Eye Research 107, pages 65-73.
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Yu-Huei Liu, Ching-Chu Chen, Li-Ling Liao, Lei Wan, Chang-Hai Tsai & Fuu-Jen Tsai. (2012) Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population. Journal of Biomedical Science 19:1.
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Rathie Rajendram, Catey Bunce, Richard WJ Lee & Ana MS Morley. (2012) Orbital radiotherapy for adult thyroid eye disease. Cochrane Database of Systematic Reviews.
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Daniel G Ezra, Jonathan Krell, Geoffrey E Rose, Maryse Bailly, Justin Stebbing & Leandro Castellano. (2012) Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathy. Journal of Clinical Pathology 65:7, pages 608-613.
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Lei Zhang, Fiona Grennan-Jones, Carol Lane, D. Aled Rees, Colin M. Dayan & Marian Ludgate. (2012) Adipose Tissue Depot-Specific Differences in the Regulation of Hyaluronan Production of Relevance to Graves' Orbitopathy. The Journal of Clinical Endocrinology & Metabolism 97:2, pages 653-662.
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Raymond S. Douglas, Shivani Gupta & Terry J. Smith. 2012. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery 1213 1223 .
Shuang-Xia Zhao, Shanli Tsui, Anthony Cheung, Raymond S Douglas, Terry J Smith & J Paul Banga. (2011) Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA. Journal of Endocrinology 210:3, pages 369-377.
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Raymond S. Douglas & Shivani Gupta. (2011) The pathophysiology of thyroid eye disease. Current Opinion in Ophthalmology 22:5, pages 385-390.
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Vibhavari M. Naik, Milind N. Naik, Robert A. Goldberg, Terry J. Smith & Raymond S. Douglas. (2010) Immunopathogenesis of Thyroid Eye Disease: Emerging Paradigms. Survey of Ophthalmology 55:3, pages 215-226.
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Rebecca S. Bahn. (2010) Graves' Ophthalmopathy. New England Journal of Medicine 362:8, pages 726-738.
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C-C Tsai, C-Y Cheng, C-Y Liu, S-C Kao, H-C Kau, W-M Hsu & Y-H Wei. (2008) Oxidative stress in patients with Graves' ophthalmopathy: relationship between oxidative DNA damage and clinical evolution. Eye 23:8, pages 1725-1730.
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Rebecca S Bahn. (2008) Is radioiodine more likely than antithyroid drugs to worsen ophthalmopathy in patients with Graves disease?. Nature Clinical Practice Endocrinology & Metabolism 4:11, pages 594-595.
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Raymond S. Douglas, Vibharavi Naik, Catherine J. Hwang, Nikoo F. Afifiyan, Andrew G. Gianoukakis, Daniel Sand, Shweta Kamat & Terry J. Smith. (2008) B Cells from Patients with Graves’ Disease Aberrantly Express the IGF-1 Receptor: Implications for Disease Pathogenesis. The Journal of Immunology 181:8, pages 5768-5774.
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Geniece M. LehmannSteven E. FeldonTerry J. SmithRichard P. Phipps. (2008) Immune Mechanisms in Thyroid Eye Disease. Thyroid 18:9, pages 959-965.
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N Lopez, A Fernandez, RJ Bosch & E Herrera. (2007) Multiple eruptive dermatofibromas in a patient with Graves‐Basedow disease. Journal of the European Academy of Dermatology and Venereology 22:3, pages 402-403.
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G. M. Lehmann, T. M. Garcia-Bates, T. J. Smith, S. E. Feldon & R. P. Phipps. (2008) Regulation of Lymphocyte Function by PPAR γ : Relevance to Thyroid Eye Disease‐Related Inflammation . PPAR Research 2008:1.
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Terry J. Smith & Raymond S. Douglas. 2008. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology 2913 2926 .
Vahab Fatourechi. 2008. Thyroid Disorders with Cutaneous Manifestations. Thyroid Disorders with Cutaneous Manifestations 103 119 .
Raymond S. Douglas, Andrew G. Gianoukakis, Shweta Kamat & Terry J. Smith. (2007) Aberrant Expression of the Insulin-Like Growth Factor-1 Receptor by T Cells from Patients with Graves’ Disease May Carry Functional Consequences for Disease Pathogenesis. The Journal of Immunology 178:5, pages 3281-3287.
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. 2007. Oculoplastics and Orbit. Oculoplastics and Orbit 123 141 .
Beiling Chen, Shanli Tsui, William E. Boeglin, Raymond S. Douglas, Alan R. Brash & Terry J. Smith. (2006) Interleukin-4 Induces 15-Lipoxygenase-1 Expression in Human Orbital Fibroblasts from Patients with Graves Disease. Journal of Biological Chemistry 281:27, pages 18296-18306.
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Raymond S. Douglas, Aparna Bhatnagar & Robert A. Goldberg. (2006) New Innovations in the Surgical Management of Thyroid-Related Orbitopathy. Techniques in Ophthalmology 4:2, pages 82-89.
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Jacqueline A. Gilbert, Andrew G. Gianoukakis, Siamak Salehi, Jane Moorhead, Prakash V. Rao, M. Zareen Khan, Alan M. McGregor, Terry J. Smith & J. Paul Banga. (2006) Monoclonal Pathogenic Antibodies to the Thyroid-Stimulating Hormone Receptor in Graves’ Disease with Potent Thyroid-Stimulating Activity but Differential Blocking Activity Activate Multiple Signaling Pathways. The Journal of Immunology 176:8, pages 5084-5092.
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Rui Han & Terry J. Smith. (2006) T Helper Type 1 and Type 2 Cytokines Exert Divergent Influence on the Induction of Prostaglandin E2 and Hyaluronan Synthesis by Interleukin-1β in Orbital Fibroblasts: Implications for the Pathogenesis of Thyroid-Associated Ophthalmopathy. Endocrinology 147:1, pages 13-19.
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T J Smith. (2005) Insights into the role of fibroblasts in human autoimmune diseases. Clinical and Experimental Immunology 141:3, pages 388-397.
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Rui Han & Terry J. Smith. (2005) Induction by IL-1β of Tissue Inhibitor of Metalloproteinase-1 in Human Orbital Fibroblasts: Modulation of Gene Promoter Activity by IL-4 and IFN-γ. The Journal of Immunology 174:5, pages 3072-3079.
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Jane Pritchard, Shanli Tsui, Noah Horst, William W. Cruikshank & Terry J. Smith. (2004) Synovial Fibroblasts from Patients with Rheumatoid Arthritis, Like Fibroblasts from Graves’ Disease, Express High Levels of IL-16 When Treated with Igs against Insulin-Like Growth Factor-1 Receptor. The Journal of Immunology 173:5, pages 3564-3569.
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