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Original Article

Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus?

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Pages 39-45 | Received 24 Oct 2004, Accepted 31 Oct 2004, Published online: 07 Jul 2009

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Read on this site (8)

Stefania Cartella, Ilaria Cavazzana, Angela Ceribelli, Flora Inverardi, Angela Tincani & Franco Franceschini. (2013) Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic Lupus erythematosus. Autoimmunity 46:6, pages 363-368.
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Zafar Rasheed, HaniA. Al-Shobaili, AhmadA. Al Robaee, AbdullateefA. Alzolibani, WalidI. A. Wadi, Muhammad Ismail Khan & HamadA. Al-Hamed. (2012) Preferential Recognition of Peroxynitrite Damaged Thymidine-Monophosphate by Anti-DNA Autoantibodies in Systemic Lupus Erythematosus. Nucleosides, Nucleotides & Nucleic Acids 31:10, pages 736-751.
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Farha A. El-Chennawi, Youssef M. Mosaad, Hesham M. Habib & Tamer El-Degheidi. (2009) Comparative Study of Antinuclear Antibody Detection by Indirect Immunofluorescence and Enzyme Immunoassay in Lupus Patients. Immunological Investigations 38:8, pages 839-850.
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Nathalie Bardin, Sophie Desplat-Jego, Laurent Daniel, Noémie Jourde Chiche & Marielle Sanmarco. (2009) BioPlex™ 2200 multiplexed system: Simultaneous detection of anti-dsDNA and anti-chromatin antibodies in patients with systemic lupus erythematosus. Autoimmunity 42:1, pages 63-68.
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Lisa K. Peterson, Takahisa Masaki, Steven R. Wheelwright, Ikuo Tsunoda & Robert S. Fujinami. (2008) Cross-reactive myelin antibody induces renal pathology. Autoimmunity 41:7, pages 526-536.
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Minoru Satoh, Edward KL Chan, Eric S Sobel, Donald L Kimpel, Yoshioki Yamasaki, Sonali Narain, Rizwan Mansoor & Westley H Reeves. (2007) Clinical implication of autoantibodies in patients with systemic rheumatic diseases. Expert Review of Clinical Immunology 3:5, pages 721-738.
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Paula Alba, Maria Laura Bertolaccini & Munther A Khamashta. (2007) The use of laboratory methods in differential diagnosis and treatment of SLE and antiphospholipid syndrome. Expert Review of Clinical Immunology 3:4, pages 613-622.
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Marta Mosca, Chiara Baldini & Stefano Bombardieri. (2007) LJP-394 (abetimus sodium) in the treatment of systemic lupus erythematosus. Expert Opinion on Pharmacotherapy 8:6, pages 873-879.
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A Becker-Merok, G Østli-Eilersten, S Lester & JC Nossent. (2012) Circulating interferon-α2 levels are increased in the majority of patients with systemic lupus erythematosus and are associated with disease activity and multiple cytokine activation. Lupus 22:2, pages 155-163.
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Brooke E. Gilliam, Amanda K. Ombrello, Rufus W. Burlingame, Peri H. Pepmueller & Terry L. Moore. (2012) Measurement of Autoantibodies in Pediatric-Onset Systemic Lupus Erythematosus and Their Relationship with Disease-Associated Manifestations. Seminars in Arthritis and Rheumatism 41:6, pages 840-848.
Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
AMANDA J. STEIMAN, DAFNA D. GLADMAN, DOMINIQUE IBAÑEZ & MURRAY B. UROWITZ. (2010) Prolonged Serologically Active Clinically Quiescent Systemic Lupus Erythematosus: Frequency and Outcome. The Journal of Rheumatology 37:9, pages 1822-1827.
Crossref
F. Fiegel, A. Buhl, H-P. Jaekel, E. Werle, M. Schmolke, M. Ollert & PB Luppa. (2010) Autoantibodies to double-stranded DNA-Intermethod comparison between four commercial immunoassays and a research biosensor-based device. Lupus 19:8, pages 957-964.
Crossref
David Launay, Jean Schmidt, Sébastien Lepers, Tristan Mirault, Marc Lambert, Xavier Kyndt, Dominique Reumaux, Alain Duhamel, Eric Hachulla, Pierre-Yves Hatron, Lionel Prin & Sylvain Dubucquoi. (2010) Comparison of the Farr radioimmunoassay, 3 commercial enzyme immunoassays and Crithidia luciliae immunofluorescence test for diagnosis and activity assessment of systemic lupus erythematosus. Clinica Chimica Acta 411:13-14, pages 959-964.
Crossref
Karsten Conrad, Annelore Ittenson, Dirk Reinhold, Richard Fischer, Dirk Roggenbuck, Thomas Büttner, Hans-Peter Bosselmann, Jörg Steinbach & Werner Schößler. (2009) High Sensitive Detection of Double-Stranded DNA Autoantibodies by a Modified Crithidia luciliae Immunofluorescence Test. Annals of the New York Academy of Sciences 1173:1, pages 180-185.
Crossref
Alexander Buhl, Sharon Page, Niels H.H. Heegaard, Philipp von Landenberg & Peter B. Luppa. (2009) Optical biosensor-based characterization of anti-double-stranded DNA monoclonal antibodies as possible new standards for laboratory tests. Biosensors and Bioelectronics 25:1, pages 198-203.
Crossref
Divi Cornec, Emilie Cornec-Le Gall, Zazou Segalen, Catherine Hanrotel-Saliou, Yannick Le Meur, Yves Renaudineau & Pierre Youinou. (2009) Which autoantibodies announce that lupus nephritis is on the way?. International Journal of Clinical Rheumatology 4:3, pages 287-295.
Crossref
GRO ØSTLI EILERTSEN, ANDREA BECKER-MEROK & JOHANNES C. NOSSENT. (2009) The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus: Epidemiology, Disease Presentation, and Patient Management. The Journal of Rheumatology 36:3, pages 552-559.
Crossref
Geneviève Servais, Rafik Karmali, Marie Paule Guillaume, Valérie Badot, Jean Duchateau & Francis Corazza. (2009) Anti DNA antibodies are not restricted to a specific pattern of fluorescence on HEp2 cells. Clinical Chemistry and Laboratory Medicine 47:5.
Crossref
Ying Tan, Feng Yu, Haizhen Yang, Min Chen, Qiying Fang & Ming-hui Zhao. (2008) Autoantibodies against monomeric C-reactive protein in sera from patients with lupus nephritis are associated with disease activity and renal tubulointerstitial lesions. Human Immunology 69:12, pages 840-844.
Crossref
Elio Tonutti, Nadia Blasone, Daniela Visentini, Monica Poletto, Danilo Villalta, Renato Tozzoli & Nicola Bizzaro. (2008) Cell lines that express membrane-associated DNA for anti-DNA antibody detection. Clinical Chemistry and Laboratory Medicine 46:4.
Crossref
Kyeong Hee Kim, Jin Yeong Han, Jeong Man Kim, Sung Won Lee & Won Tae Chung. (2007) Clinical significance of ELISA positive and immunofluorescence negative anti-dsDNA antibody. Clinica Chimica Acta 380:1-2, pages 182-185.
Crossref
A.S. Wiik. (2007) Diagnostische Strategien bei rheumatischen AutoimmunerkrankungenDiagnostic strategies for autoimmune rheumatic diseases. Zeitschrift für Rheumatologie 66:3, pages 219-224.
Crossref
Michael Mahler & Marvin J Fritzler. (2007) Anti-dsDNA antibody testing in the clinic: Farr or ELISA?. Nature Clinical Practice Rheumatology 3:2, pages 72-73.
Crossref
Mary Anne Dooley & Ronald J. Falk. (2007) Human Clinical Trials in Lupus Nephritis. Seminars in Nephrology 27:1, pages 115-127.
Crossref
DÖRTE HAMANN & RUUD J.T. SMEENK. 2007. Autoantibodies. Autoantibodies 159 167 .
A WiikR Cervera, M Haass, M Khamashta, PL Meroni, J-C Piette, R Schmitt & Y Shoenfeld. (2016) European Attempts to Set Guidelines for Improving Diagnostics of Autoimmune Rheumatic Disorders. Lupus 15:7, pages 391-396.
Crossref
H-P JaekelA Trabandt, N Grobe & E Werle. (2016) Anti-dsDNA antibody subtypes and anti-C1q antibodies: toward a more reliable diagnosis and monitoring of systemic lupus erythematosus and lupus nephritis. Lupus 15:6, pages 335-345.
Crossref
Tanja Lövgren, Maija‐Leena Eloranta, Berthold Kastner, Marie Wahren‐Herlenius, Gunnar V. Alm & Lars Rönnblom. (2006) Induction of interferon‐α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen– and Sjögren's syndrome autoantigen–associated RNA. Arthritis & Rheumatism 54:6, pages 1917-1927.
Crossref
R Prasad, D Ibañez, D Gladman & M Urowitz. (2016) Anti-dsDNA and anti-Sm antibodies do not predict damage in systemic lupus erythematosus. Lupus 15:5, pages 285-291.
Crossref
M. Gaubitz & H. Schotte. (2005) Frühdiagnose des systemischen Lupus erythematodes (SLE)Early diagnosis in patients with systemic lupus erythematosus. Zeitschrift für Rheumatologie 64:8, pages 547-552.
Crossref

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