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Original Article

Innate and Acquired Immunity in the Pathogenesis of Chagas Disease

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Pages 399-409 | Accepted 14 Apr 2004, Published online: 07 Jul 2009

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Fernando J Sánchez-Valdéz, Cecilia Pérez Brandán, Arturo Ferreira & Miguel Ángel Basombrío. (2015) Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease. Expert Review of Vaccines 14:5, pages 681-697.
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Luciane R Portugal, Luciana R Fernandes & Jacqueline I Alvarez-Leite. (2009) Host cholesterol and inflammation as common key regulators of toxoplasmosis and artherosclerosis development. Expert Review of Anti-infective Therapy 7:7, pages 807-819.
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Amanda C. O. Silva, Maiara Bonfim, Jonathan L. M. Fontes, Washington L. C. dos-Santos, José Mengel & Fabíola Cardillo. (2022) C57BL/6 Mice Pretreated With Alpha-Tocopherol Show a Better Outcome of Trypanosoma cruzi Infection With Less Tissue Inflammation and Fibrosis. Frontiers in Immunology 13.
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Ludmila Rodrigues Pinto Ferreira. 2022. Transcriptomics in Health and Disease. Transcriptomics in Health and Disease 437 452 .
Dunia M. Medina-Buelvas, Miriam Rodríguez-Sosa & Libia Vega. (2021) Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi. Pathogens 10:11, pages 1444.
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Gisele Macêdo Rodrigues da Cunha, Maíra Araújo Azevedo, Denise Silva Nogueira, Marianna de Carvalho Clímaco, Edward Valencia Ayala, Juan Atilio Jimenez Chunga, Raul Jesus Ynocente La Valle, Lucia Maria da Cunha Galvão, Egler Chiari, Carlos Ramon Nascimento Brito, Rodrigo Pedro Soares, Paula Monalisa Nogueira, Ricardo Toshio Fujiwara, Ricardo Gazzinelli, Robert Hincapie, Carlos-Sanhueza Chaves, Fabricio Marcus Silva Oliveira, M. G. Finn & Alexandre Ferreira Marques. (2021) α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model. PLOS Neglected Tropical Diseases 15:7, pages e0009613.
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Aline Maria Vasconcelos Queiroz, Yulia Aleksandrovna Yanshina, Emily Thays da Silva Rodrigues, Fred Luciano Neves Santos, Paola Alejandra Fiorani Celedon, Sweta Maheshwari, Sandra Beatriz Gabelli, Carla Stephanie Peucelle Rubio, Aritz Durana, Diego M.A. Guérin & Marcelo Sousa Silva. (2021) Antibodies response induced by recombinant virus-like particles from Triatoma virus and chimeric antigens from Trypanosoma cruzi. Vaccine 39:33, pages 4723-4732.
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Roberta Lattanzi, Daniela Maftei, Maria Rosaria Fullone & Rossella Miele. (2020) Trypanosoma cruzi trans‐sialidase induces STAT3 and ERK activation by prokineticin receptor 2 binding . Cell Biochemistry and Function 39:2, pages 326-334.
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Thaiany G. Souza-Silva, Diego F. Vilas-Boas, Elda Gonçalves-Santos, Ana Lia Mazzeti, Ivo S. Caldas, Reggiani V. Gonçalves, Lívia F. Diniz & Rômulo D. Novaes. (2020) Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study. Life Sciences 257, pages 118067.
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Renan V.H. de Carvalho & Dario S. Zamboni. (2020) Inflammasome Activation in Response to Intracellular Protozoan Parasites. Trends in Parasitology 36:5, pages 459-472.
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Mauricio Llaguno, Marcos Vinicius da Silva, Lara Rocha Batista, Djalma Alexandre Alves da Silva, Rodrigo Cunha de Sousa, Luiz Antonio Pertili Rodrigues de Resende, Valdo Jose Dias da Silva, Eliane Lages-Silva, Carlo José Freire Oliveira, Juliana Reis Machado, Denise Bertulucci Rocha Rodrigues, Dalmo Correia & Virmondes Rodrigues. (2019) T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment. Infection and Immunity 87:8.
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Dayane Andriotti Otta, Fernanda Fortes de Araújo, Vitor Bortolo de Rezende, Elaine Maria Souza-Fagundes, Silvana Maria Elói-Santos, Matheus Fernandes Costa-Silva, Raiany Araújo Santos, Heloísa Alves Costa, Jair Lage Siqueira-Neto, Olindo Assis Martins-Filho & Andréa Teixeira-Carvalho. (2018) Identification of Anti-Trypanosoma cruzi Lead Compounds with Putative Immunomodulatory Activity. Antimicrobial Agents and Chemotherapy 62:4.
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Déborah Maria Moreira da Silva, Laila Pinheiro, Cristiano Schetini Azevedo, Guilherme de Paula Costa & André Talvani. (2017) Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi. Revista da Sociedade Brasileira de Medicina Tropical 50:3, pages 341-349.
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Leonn Mendes Soares Pereira, Samara Tatielle Monteiro Gomes, Ricardo Ishak & Antonio Carlos Rosário Vallinoto. (2017) Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis. Frontiers in Immunology 8.
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Deena Shrestha, Bijay Bajracharya, Guilherme Paula-Costa, Beatriz C Salles, Ana Luísa J Leite, Ana Paula J Menezes, Débora MS Souza, Laser AM Oliveira & André Talvani. (2017) Expression and production of cardiac angiogenic mediators depend on the Trypanosoma cruzi-genetic population in experimental C57BL/6 mice infection. Microvascular Research 110, pages 56-63.
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Pamela Cribb, Virginia Perdomo, Victoria L. Alonso, Romina Manarin, Jorge Barrios-Pay?n, Brenda Marquina-Castillo, Luis Tavernelli & Rogelio Hern?ndez-Pando. (2017) Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells. PLOS Neglected Tropical Diseases 11:2, pages e0005350.
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Josiane F. Silva, Luciano S.A. Capettini, José F.P. da Silva, Policarpo Sales-Junior, Jader Santos Cruz, Steyner F. Cortes & Virginia S. Lemos. (2016) Mechanisms of vascular dysfunction in acute phase of Trypanosoma cruzi infection in mice. Vascular Pharmacology 82, pages 73-81.
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Rômulo Dias Novaes, Marcus Vinicius Pessoa Sartini, João Paulo Ferreira Rodrigues, Reggiani Vilela Gonçalves, Eliziária Cardoso Santos, Raquel Lopes Martins Souza & Ivo Santana Caldas. (2016) Curcumin Enhances the Anti-Trypanosoma cruzi Activity of Benznidazole-Based Chemotherapy in Acute Experimental Chagas Disease. Antimicrobial Agents and Chemotherapy 60:6, pages 3355-3364.
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Mário Alberto C. Silva-Neto, Angela H. Lopes & Georgia C. Atella. (2016) Here, There, and Everywhere: The Ubiquitous Distribution of the Immunosignaling Molecule Lysophosphatidylcholine and Its Role on Chagas Disease. Frontiers in Immunology 7.
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João Henrique Campos, Rodrigo Pedro Soares, Kleber Ribeiro, André Cronemberger Andrade, Wagner Luiz Batista & Ana Claudia Torrecilhas. (2015) Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases. Journal of Immunology Research 2015, pages 1-14.
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Veronica Schmitz, Larissa Nogueira Almeida, Erik Svensjö, Ana Carolina Monteiro, Jörg Köhl & Julio Scharfstein. (2014) C5a and Bradykinin Receptor Cross-Talk Regulates Innate and Adaptive Immunity in Trypanosoma cruzi Infection . The Journal of Immunology 193:7, pages 3613-3623.
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Lindice Mitie Nisimura, Vanessa Estato, Elen Mello de Souza, Patricia A. Reis, Marcos Adriano Lessa, Hugo Caire Castro-Faria-Neto, Mirian Claudia de Souza Pereira, Eduardo Tibiriçá & Luciana Ribeiro Garzoni. (2014) Acute Chagas Disease Induces Cerebral Microvasculopathy in Mice. PLoS Neglected Tropical Diseases 8:7, pages e2998.
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Lúcia Cristina Jamli Abel, Ludmila Rodrigues Pinto Ferreira, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo Tostes Gazzinelli, Luiz Vicente Rizzo & Edecio Cunha-Neto. (2014) Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN- γ and CD40-CD40L Interactions . Mediators of Inflammation 2014, pages 1-7.
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Ludmila Rodrigues P. Ferreira & Edecio Cunha-Neto. 2014. Transcriptomics in Health and Disease. Transcriptomics in Health and Disease 311 325 .
Mariela Natacha González, Nilay Dey, Nisha Jain Garg & Miriam Postan. (2013) Granulocyte colony-stimulating factor partially repairs the damage provoked by Trypanosoma cruzi in murine myocardium. International Journal of Cardiology 168:3, pages 2567-2574.
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Diego C. Borges, Natalia M. Araújo, Cristina R. Cardoso & Javier E. Lazo Chica. (2013) Different parasite inocula determine the modulation of the immune response and outcome of experimental T rypanosoma cruzi infection . Immunology 138:2, pages 145-156.
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F.F. de Araújo, R. Corrêa-Oliveira, M.O.C. Rocha, A.T. Chaves, J.A. Fiuza, R.C.G. Fares, K.S. Ferreira, M.C.P. Nunes, T.S. Keesen, M.P.S. Damasio, A. Teixeira-Carvalho & J.A.S. Gomes. (2012) Foxp3+CD25high CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity. Immunobiology 217:8, pages 768-777.
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Karine Rezende-Oliveira, Ronaldo Rodrigues Sarmento & Virmondes Rodrigues Junior. (2012) Production of cytokine and chemokines by human mononuclear cells and whole blood cells after infection with Trypanosoma cruzi. Revista da Sociedade Brasileira de Medicina Tropical 45:1, pages 45-50.
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Mauricio M. Rodrigues, Ana Carolina Oliveira & Maria Bellio. (2012) The Immune Response to Trypanosoma cruzi : Role of Toll-Like Receptors and Perspectives for Vaccine Development . Journal of Parasitology Research 2012, pages 1-12.
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Alexandre Barcelos Morais da Silveira, Enio C. de Oliveira, Salustiano G. Neto, Alejandro O. Luquetti, Ricardo Toshio Fujiwara, Rodrigo Correa Oliveira & Axel Brehmer. (2011) Enteroglial cells act as antigen-presenting cells in chagasic megacolon. Human Pathology 42:4, pages 522-532.
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Marina V. ChuenkovaMercio PereiraPerrin. (2009) Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Antiapoptotic Strategy . Science Signaling 2:97.
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