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Original

PD-1/PD-L pathway and autoimmunity

Pages 353-357 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Zixia Wu, Miao Miao, Yuhua Qiu, Zhenghong Qin, Jin Wang, Yiguo Jiang, Zhijun Ming & Xueguang Zhang. (2013) Association between polymorphisms in PDCD1 gene and aplastic anemia in Chinese Han population. Leukemia & Lymphoma 54:10, pages 2251-2254.
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Konstantin Yakimchuk, Kutty Selva Nandakumar, Liying Chen, Rikard Holmdahl, Sam Okret & Mikael Jondal. (2012) Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis. Autoimmunity 45:7, pages 510-515.
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Sergio M Calixto & Chandra Mohan. (2007) Lupus genes at the interface of tolerance and autoimmunity. Expert Review of Clinical Immunology 3:4, pages 603-611.
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Crossref
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Crossref
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Crossref
Wayne Truong, Wayne W Hancock, Jennifer C Plester, Shaheed Merani, David C Rayner, Govindarajan Thangavelu, Kenneth M Murphy, Colin C Anderson & A. M. James Shapiro. (2009) BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. Journal of Leukocyte Biology 86:1, pages 41-51.
Crossref
Stephen C. Pflugfelder & Michael E. Stern. (2009) Immunoregulation on the Ocular Surface: 2nd Cullen Symposium. The Ocular Surface 7:2, pages 67-77.
Crossref
Scherezade Momin, Sylvia Flores, Bárbara Angel B, Ethel Codner D, Elena Carrasco P & Francisco Perez-Bravo. (2009) Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes. Diabetes Research and Clinical Practice 83:3, pages 289-294.
Crossref
MURAT ICEN, PAULO J. NICOLA, HILAL MARADIT-KREMERS, CYNTHIA S. CROWSON, TERRY M. THERNEAU, ERIC L. MATTESON & SHERINE E. GABRIEL. (2009) Systemic Lupus Erythematosus Features in Rheumatoid Arthritis and Their Effect on Overall Mortality. The Journal of Rheumatology 36:1, pages 50-57.
Crossref
YH Lee, JH Woo, SJ Choi, JD Ji & GG Song. (2009) Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus 18:1, pages 9-15.
Crossref
Kenneth Murphy, Paul Travers & Mark Walport. 2009. Janeway Immunologie. Janeway Immunologie 753 823 .
Arlene T. Tieng & Elena Peeva. (2008) B-Cell-Directed Therapies in Systemic Lupus Erythematosus. Seminars in Arthritis and Rheumatism 38:3, pages 218-227.
Crossref
Luc Xerri, Bruno Chetaille, Nacer Seriari, Coralie Attias, Yves Guillaume, Christine Arnoulet & Daniel Olive. (2008) Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Human Pathology 39:7, pages 1050-1058.
Crossref
Brian D. Juran & Konstantinos N. Lazaridis. (2008) Genetics and Genomics of Primary Biliary Cirrhosis. Clinics in Liver Disease 12:2, pages 349-365.
Crossref
David A. Hokey, F. Brad Johnson, Jasmine Smith, Joshua L. Weber, Jian Yan, Lauren Hirao, Jean D. Boyer, Mark G. Lewis, George Makedonas, Michael R. Betts & David B. Weiner. (2008) Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. European Journal of Immunology 38:5, pages 1435-1445.
Crossref
Xian-Hui He, Qian-Tao Jia, Feng-Yao Li, Mark Saltis, Yi Liu, Li-Hui Xu & Qing-Bing Zha. (2008) CD8+ T cells specific for both persistent and non-persistent viruses display distinct differentiation phenotypes but have similar level of PD-1 expression in healthy Chinese individuals. Clinical Immunology 126:2, pages 222-234.
Crossref
Brian D. Juran, Elizabeth J. Atkinson, Erik M. Schlicht, Brooke L. Fridley, Gloria M. Petersen & Konstantinos N. Lazaridis. (2007) Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis. Hepatology 47:2, pages 563-570.
Crossref
Francesco Bifari, Veronica Lisi, Elda Mimiola, Annalisa Pasini & Mauro Krampera. (2008) Immune Modulation by Mesenchymal Stem Cells. Transfusion Medicine and Hemotherapy 35:3, pages 194-204.
Crossref
Z. Fabry, E. Reinke, A. Zozulya, M. Sandor & I. Bechmann. 2008. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 197 221 .
Delphine Sauce, Jorge R Almeida, Martin Larsen, Laurine Haro, Brigitte Autran, Gordon J Freeman & Victor Appay. (2007) PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS 21:15, pages 2005-2013.
Crossref
Ronghua Ni, Kenji Ihara, Kenichi Miyako, Ryuichi Kuromaru, Mika Inuo, Hitoshi Kohno & Toshiro Hara. (2007) PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. Human Genetics 121:2, pages 223-232.
Crossref
R. J. Rigby, M. M. A. Fernando & T. J. Vyse. (2006) Mice, humans and haplotypes—the hunt for disease genes in SLE. Rheumatology 45:9, pages 1062-1067.
Crossref
Kenneth M. Murphy, Christopher A. Nelson & John R. Šedý. (2006) Balancing co-stimulation and inhibition with BTLA and HVEM. Nature Reviews Immunology 6:9, pages 671-681.
Crossref
Maya Gavrieli, John Sedy, Christopher A. Nelson,Kenneth M. Murphy. 2006. 157 185 .

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