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Original

Natural antibodies, autoantibodies and complement activation in tissue injury

Pages 379-386 | Received 19 Feb 2006, Accepted 06 Apr 2006, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Aleksandra Urban, Anna Borowska, Anna Felberg, Lambertus van den Heuvel, Grzegorz Stasiłojć, Elena Volokhina & Marcin Okrój. (2018) Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays. Autoimmunity 51:1, pages 18-24.
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M. Zouhair Atassi, Paolo Casali, M. Zouhair Atassi & Paolo Casali. (2008) Molecular mechanisms of autoimmunity. Autoimmunity 41:2, pages 123-132.
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Liudmila Kulik, Brandon Renner, Jennifer Laskowski, Joshua M. Thurman & V. Michael Holers. (2023) Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid. Molecular Immunology 157, pages 112-128.
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Nirmal K. Banda, Stephen Tomlinson, Robert I. Scheinman, Nhu Ho, Joseline Ramos Ramirez, Gaurav Mehta, Guankui Wang, Vivian Pham Vu, Dmitri Simberg, Liudmila Kulik & V. Michael Holers. (2020) C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice. Frontiers in Immunology 11.
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Tineke Kardol-HoefnagelSofie A.L.M. van LogtestijnHenny G. Otten. (2020) A Review on the Function and Regulation of ARHGDIB/RhoGDI2 Expression Including the Hypothetical Role of ARHGDIB/RhoGDI2 Autoantibodies in Kidney Transplantation. Transplantation Direct 6:5, pages e548.
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Sergio Arlati. 2019. Operative Techniques and Recent Advances in Acute Care and Emergency Surgery. Operative Techniques and Recent Advances in Acute Care and Emergency Surgery 11 42 .
Anders Lund, Lasse Melvaer Giil, Grete Slettom, Ottar Nygaard, Harald Heidecke & Jan Erik Nordrehaug. (2018) Antibodies to receptors are associated with biomarkers of inflammation and myocardial damage in heart failure. International Journal of Cardiology 250, pages 253-259.
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Richard J. Pleass, Shona C. Moore, Liz Stevenson & Lars Hviid. (2016) Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria. Trends in Parasitology 32:2, pages 108-119.
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Ya-ping Wang, Yao Xie, Hong Ma, Sheng-an Su, Yi-dong Wang, Jian-an Wang & Mei-xiang Xiang. (2016) Regulatory T lymphocytes in myocardial infarction: A promising new therapeutic target. International Journal of Cardiology 203, pages 923-928.
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Michael R. Pope & Sherry D. Fleming. (2015) TLR2 Modulates Antibodies Required for Intestinal Ischemia/Reperfusion-Induced Damage and Inflammation. The Journal of Immunology 194:3, pages 1190-1198.
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Lothar Rink, Andrea Kruse & Hajo HaaseAndrea Kruse. 2015. Immunologie für Einsteiger. Immunologie für Einsteiger 141 152 .
Miriam D Neher, Megan C Rich, Chesleigh N Keene, Sebastian Weckbach, Ashley L Bolden, Justin T Losacco, Jenée Patane, Michael A Flierl, Liudmila Kulik, V Michael Holers & Philip F Stahel. (2014) Deficiency of complement receptors CR2/CR1 in Cr2 -/-mice reduces the extent of secondary brain damage after closed head injury. Journal of Neuroinflammation 11:1.
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R.R. Redfield, Y. Lou, E. Rodriguez, S. Rostami, R.F. Parsons, H. Noorchashm, A. Naji & P.L. Abt. (2013) Sustained reduction of alloantibody secreting plasma cells and donor specific antibody with proteasome inhibition in mice. Transplant Immunology 29:1-4, pages 11-16.
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Lakshmi KannanKatalin Kis-TothKazuhisa YoshiyaTo-Ha ThaiSeema Sehrawat, Tanya N. Mayadas, Jurandir J. Dalle Lucca & George C. Tsokos. (2013) R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage. Proceedings of the National Academy of Sciences 110:35, pages 14348-14353.
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Sebastian WeckbachMiriam NeherJustin T. LosaccoAshley L. BoldenLiudmila KulikMichael A. FlierlScott E. BellV. Michael HolersPhilip F. Stahel. (2012) Challenging the Role of Adaptive Immunity in Neurotrauma: Rag1 −/− Mice Lacking Mature B and T Cells Do Not Show Neuroprotection after Closed Head Injury . Journal of Neurotrauma 29:6, pages 1233-1242.
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Lothar Rink, Andrea Kruse & Hajo HaaseLothar Rink, Andrea Kruse & Hajo Haase. 2012. Immunologie für Einsteiger. Immunologie für Einsteiger 169 183 .
H. Christian Volz, Sebastian J. Buss, Jin Li, Stefan Göser, Martin Andrassy, Renate Öttl, Gabriele Pfitzer, Hugo A. Katus & Ziya Kaya. (2014) Autoimmunity against cardiac troponin I in ischaemia reperfusion injury. European Journal of Heart Failure 13:10, pages 1052-1059.
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Jie Chen, José C. Crispín, Jurandir Dalle Lucca & George C. Tsokos. (2011) A Novel Inhibitor of the Alternative Pathway of Complement Attenuates Intestinal Ischemia/Reperfusion-Induced Injury. Journal of Surgical Research 167:2, pages e131-e136.
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Keith M. Woods, Michael R. Pope, Sara M. Hoffman & Sherry D. Fleming. (2011) CR2+ Marginal Zone B Cell Production of Pathogenic Natural Antibodies Is C3 Independent. The Journal of Immunology 186:3, pages 1755-1762.
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Sara M. Hoffman, Hua Wang, Michael R. Pope & Sherry D. Fleming. (2011) Helicobacter ?infection alters MyD88 and Trif signalling in response to intestinal ischaemia-reperfusion . Experimental Physiology 96:2, pages 104-113.
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Haekyung Lee, Danielle J. Green, Lawrence Lai, Yunfang Joan Hou, Jens C. Jensenius, David Liu, Cheolho Cheong, Chae Gyu Park & Ming Zhang. (2010) Early complement factors in the local tissue immunocomplex generated during intestinal ischemia/reperfusion injury. Molecular Immunology 47:5, pages 972-981.
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Caylib A. Durand, Karsten Hartvigsen, Linda Fogelstrand, Shin Kim, Sally Iritani, Bart Vanhaesebroeck, Joseph L. Witztum, Kamal D. Puri & Michael R. Gold. (2009) Phosphoinositide 3-Kinase p110δ Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses. The Journal of Immunology 183:9, pages 5673-5684.
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Daniel M. Czajkowsky & Zhifeng Shao. (2009) The human IgM pentamer is a mushroom-shaped molecule with a flexural bias. Proceedings of the National Academy of Sciences 106:35, pages 14960-14965.
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Marlene L. Rose & John D. Smith. (2009) Clinical relevance of complement-fixing antibodies in cardiac transplantation. Human Immunology 70:8, pages 605-609.
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M. Joerink, E. Rindsjö, F. Stenius, J. Alm, G. Lilja, H. Grönlund & A. Scheynius. (2009) Evidence for allergen-specific IgE of maternal origin in human placenta. Allergy 64:6, pages 905-912.
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Maciej M. Markiewski, Robert A. DeAngelis, Christoph W. Strey, Periklis G. Foukas, Craig Gerard, Norma Gerard, Rick A. Wetsel & John D. Lambris. (2009) The Regulation of Liver Cell Survival by Complement. The Journal of Immunology 182:9, pages 5412-5418.
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John D. Smith, Iman M. Hamour, Margaret M. Burke, Balikrishnan Mahesh, Rachel E. Stanford, Saleem Haj-Yahia, Derek R. Robinson, Pradeep Kaul, Magdi H. Yacoub, Nicholas R. Banner & Marlene L. Rose. (2009) A Reevaluation of the Role of IgM Non-HLA Antibodies in Cardiac Transplantation. Transplantation 87:6, pages 864-871.
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Sherry D. Fleming, Lauren M. Phillips, John D. Lambris & George C. Tsokos. (2008) Complement Component C5a Mediates Hemorrhage-Induced Intestinal Damage. Journal of Surgical Research 150:2, pages 196-203.
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Keith Elkon & Paolo Casali. (2008) Nature and functions of autoantibodies. Nature Clinical Practice Rheumatology 4:9, pages 491-498.
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M. Z. Ratajczak, R. Reca, M. Wysoczynski, M. Kucia & J. Ratajczak. 2008. National Institute of Allergy and Infectious Diseases, NIH. National Institute of Allergy and Infectious Diseases, NIH 357 364 .
Ryan Reca, Daniel Cramer, Jun Yan, Mary J. Laughlin, Anna Janowska-Wieczorek, Janina Ratajczak & Mariusz Z. Ratajczak. (2007) A Novel Role of Complement in Mobilization: Immunodeficient Mice Are Poor Granulocyte-Colony Stimulating Factor Mobilizers Because They Lack Complement-Activating Immunoglobulins. Stem Cells 25:12, pages 3093-3100.
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Philip F. Stahel, Wade R. Smith & Ernest E. Moore. (2007) Role of biological modifiers regulating the immune response after trauma. Injury 38:12, pages 1409-1422.
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