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Autoimmunity Volume 40, 2007 - Issue 6
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Original

Role of phosphoinositide 3-kinase signaling in autoimmunity

Jean S. Oak Department of Molecular Biology and Biochemistry, Center for Immunology, University of California, Irvine, CA92697, USA
&
David A. Fruman Department of Molecular Biology and Biochemistry, Center for Immunology, University of California, Irvine, CA92697, USA
Pages 433-441 | Published online: 07 Jul 2009

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Thilipan Thaventhiran, Naif Alhumeed, Han XA Yeang, Swaminathan Sethu, Jocelyn S Downey, Ahmad F Alghanem, Adedamola Olayanju, Emma L Smith, Michael J Cross, Steven D Webb, Dominic P Williams, Adrian Bristow, Christina Ball, Richard Stebbings & Jean G Sathish. (2014) Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. mAbs 6:5, pages 1290-1299.
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Bart Vanhaesebroeck, Matthew W. D. Perry, Jennifer R. Brown, Fabrice André & Klaus Okkenhaug. (2021) PI3K inhibitors are finally coming of age. Nature Reviews Drug Discovery 20:10, pages 741-769.
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Wei Ge, Hai-Yan Wang, Hai-Mei Zhao, Xue-Ke Liu, You-Bao Zhong, Jian Long, Zheng-Yun Zuo & Duan-Yong Liu. (2020) Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium. Frontiers in Pharmacology 11.
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Emily S.J. Edwards, Julia Bier, Theresa S. Cole, Melanie Wong, Peter Hsu, Lucinda J. Berglund, Kaan Boztug, Anthony Lau, Emma Gostick, David A. Price, Michael O'Sullivan, Isabelle Meyts, Sharon Choo, Paul Gray, Steven M. Holland, Elissa K. Deenick, Gulbu Uzel & Stuart G. Tangye. (2019) Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity. Journal of Allergy and Clinical Immunology 143:1, pages 276-291.e6.
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Shengnan Yang, Yuan Zhang, Fukui Shen, Xiaoyao Ma, Man Zhang, Yuanyuan Hou & Gang Bai. (2019) The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation. FEBS Letters 593:2, pages 175-186.
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Alaa Kassim Ali, Neethi Nandagopal & Seung-Hwan Lee. (2015) IL-15–PI3K–AKT–mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells. Frontiers in Immunology 6.
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Sudhir Kshirsagar, Elisabeth Binder, Magdalena Riedl, Gottfried Wechselberger, Elisabeth Steichen & Monika Edelbauer. (2013) Enhanced Activity of Akt in Teff Cells From Children With Lupus Nephritis Is Associated With Reduced Induction of Tumor Necrosis Factor Receptor–Associated Factor 6 and Increased OX40 Expression. Arthritis & Rheumatism 65:11, pages 2996-3006.
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Francisco Victorino & Scott Alper. (2012) Identifying novel spatiotemporal regulators of innate immunity. Immunologic Research 55:1-3, pages 3-9.
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Kenichiro MaedaHarshini Mehta, Douglas A. Drevets & K. Mark Coggeshall. (2010) IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood 115:23, pages 4699-4706.
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David A. Fruman. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 1049 1060 .
David A. Fruman & Georges Bismuth. (2009) Fine tuning the immune response with PI3K. Immunological Reviews 228:1, pages 253-272.
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Maria Teresa Savino, Barbara Ortensi, Micol Ferro, Cristina Ulivieri, Daniela Fanigliulo, Eugenio Paccagnini, Stefano Lazzi, Daniela Osti, Giuliana Pelicci & Cosima T. Baldari. (2009) Rai Acts as a Negative Regulator of Autoimmunity by Inhibiting Antigen Receptor Signaling and Lymphocyte Activation. The Journal of Immunology 182:1, pages 301-308.
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E. Nigel WardleE. Nigel Wardle. 2009. Guide to Signal Pathways in Immune Cells. Guide to Signal Pathways in Immune Cells 11 23 .

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