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Original

The genetics and biology of Irf5-mediated signaling in lupus

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Pages 591-601 | Received 12 Feb 2007, Accepted 07 Jun 2007, Published online: 07 Jul 2009

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Ashwinder Kaur, Learn-Han Lee, Sek-Chuen Chow & Chee-Mun Fang. (2018) IRF5-mediated immune responses and its implications in immunological disorders. International Reviews of Immunology 37:5, pages 229-248.
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Inez Rogatsky, Uma Chandrasekaran, Michela Manni, Woelsung Yi & Alessandra B. Pernis. (2014) Epigenetics and the IRFs: A complex interplay in the control of immunity and autoimmunity. Autoimmunity 47:4, pages 242-255.
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Corinne Miceli-Richard & Lindsey A Criswell. (2014) Genetic, genomic and epigenetic studies as tools for elucidating disease pathogenesis in primary Sjögren’s syndrome. Expert Review of Clinical Immunology 10:4, pages 437-444.
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Michael R York. (2011) Novel insights on the role of the innate immune system in systemic sclerosis. Expert Review of Clinical Immunology 7:4, pages 481-489.
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Laura M Burdick, Najwa Somani & Ally-Khan Somani. (2009) Type I IFNs and their role in the development of autoimmune diseases. Expert Opinion on Drug Safety 8:4, pages 459-472.
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Christophe Richez, Kei Yasuda, Ramon G. Bonegio, Amanda A. Watkins, Tamar Aprahamian, Patricia Busto, Rocco J. Richards, Chih Long Liu, Regina Cheung, Paul J. Utz, Ann Marshak-Rothstein & Ian R. Rifkin. (2010) IFN Regulatory Factor 5 Is Required for Disease Development in the FcγRIIB−/−Yaa and FcγRIIB−/− Mouse Models of Systemic Lupus Erythematosus . The Journal of Immunology 184:2, pages 796-806.
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Angélica M Delgado-Vega, Marta E Alarcón-Riquelme & Sergey V Kozyrev. (2010) Genetic associations in type I interferon related pathways with autoimmunity. Arthritis Research & Therapy 12:Suppl 1, pages S2.
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George D Kalliolias & Lionel B Ivashkiv. (2010) Overview of the biology of type I interferons. Arthritis Research & Therapy 12:Suppl 1, pages S1.
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Emily Walters, Virginia Rider, Nabih I. Abdou, Cindy Greenwell, Stan Svojanovsky, Peter Smith & Bruce F. Kimler. (2009) Estradiol targets T cell signaling pathways in human systemic lupus. Clinical Immunology 133:3, pages 428-436.
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ANNA HELLQUIST, TIINA M. JÄRVINEN, SARI KOSKENMIES, MARCO ZUCCHELLI, CHRISTINA ORSMARK-PIETRAS, LINDA BERGLIND, JAANA PANELIUS, TAINA HASAN, HEIKKI JULKUNEN, MAURO D’AMATO, ULPU SAARIALHO-KERE & JUHA KERE. (2009) Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus Erythematosus . The Journal of Rheumatology 36:8, pages 1631-1638.
Crossref
Chau-Ching Liu & Joseph M. Ahearn. (2009) The search for lupus biomarkers. Best Practice & Research Clinical Rheumatology 23:4, pages 507-523.
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Young Ho Lee & Gwan Gyu Song. (2008) Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus: a meta-analysis. Rheumatology International 29:10, pages 1137-1142.
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Alexander TorresAli D AskariCharles J Malemud. (2009) Cardiovascular disease complications in systemic lupus erythematosus. Biomarkers in Medicine 3:3, pages 239-252.
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A. Neil Crowson & Cynthia M. Magro. (2009) Cutaneous histopathology of lupus erythematosus. Diagnostic Histopathology 15:4, pages 157-185.
Crossref
B. Rhodes & T. J. Vyse. (2008) The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology 47:11, pages 1603-1611.
Crossref
Swapan K Nath & Amr H Sawalha. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.

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