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Autoimmunity Volume 41, 2008 - Issue 1
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Original

Increased spontaneous activity of a network of hippocampal neurons in culture caused by suppression of inhibitory potentials mediated by anti-gad antibodies

Marika Vianello Department of Neurology, “Ca' Foncello” General Hospital, Treviso, Italy
,
Marika Vianello Department of Neurology, “Ca' Foncello” General Hospital, Treviso, Italy
,
Giacomo Bisson Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
,
Marika Vianello Department of Neurology, “Ca' Foncello” General Hospital, Treviso, Italy
,
Giacomo Bisson Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
,
Marco Dal Maschio Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
,
Stefano Vassanelli Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
,
Stefano Girardi Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
,
Carla Mucignat Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
,
Kostantinos Fountzoulas Section of Physiology, Department of Human Anatomy and Physiology, University of Padova, Pauda, Italy
&
Bruno Giometto Department of Neurology, “Ca' Foncello” General Hospital, Treviso, Italy
 show all
Pages 66-73 | Published online: 07 Jul 2009

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Harry Alexopoulos & Marinos C Dalakas. (2013) Immunology of stiff person syndrome and other GAD-associated neurological disorders. Expert Review of Clinical Immunology 9:11, pages 1043-1053.
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Pabitra Basnyat, Maria Peltola, Jani Raitanen, Suvi Liimatainen, Sirpa Rainesalo, Marko Pesu & Jukka Peltola. (2023) Elevated IL-6 plasma levels are associated with GAD antibodies-associated autoimmune epilepsy. Frontiers in Cellular Neuroscience 17.
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Ionut-Flavius Bratu, Adriana Elena Nica, Irina Oane, Andrei Daneasa, Sergiu Stoica, Andrei Barborica & Ioana Mindruta. (2023) Musicogenic seizures in temporal lobe epilepsy: Case reports based on ictal source localization analysis. Frontiers in Neurology 14.
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Lisa Gillinder & Jeffrey Britton. (2022) Autoimmune-Associated Seizures. CONTINUUM: Lifelong Learning in Neurology 28:2, pages 363-398.
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Estefanía Conde-Blanco, Saül Pascual-Diaz, Mar Carreño, Emma Muñoz-Moreno, José Carlos Pariente, Teresa Boget, Isabel Manzanares, Antonio Donaire, María Centeno, Francesc Graus & Nuria Bargalló. (2021) Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy. Scientific Reports 11:1.
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Popianna Tsiortou, Harry Alexopoulos & Marinos C. Dalakas. (2021) GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions. Therapeutic Advances in Neurological Disorders 14, pages 175628642110034.
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Francesc Graus, Albert Saiz & Josep Dalmau. (2020) GAD antibodies in neurological disorders — insights and challenges. Nature Reviews Neurology 16:7, pages 353-365.
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Maëlle Dade, Giulia Berzero, Cristina Izquierdo, Marine Giry, Marion Benazra, Jean-Yves Delattre, Dimitri Psimaras & Agusti Alentorn. (2020) Neurological Syndromes Associated with Anti-GAD Antibodies. International Journal of Molecular Sciences 21:10, pages 3701.
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Xinxin Li, Qi Guo, Zhaoshi Zheng, Xiaoshuang Wang & Songyan Liu. (2020) Immune-mediated epilepsy with GAD65 antibodies. Journal of Neuroimmunology 341, pages 577189.
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Bernd Frerker, Marco Rohde, Steffen Müller, Christian G. Bien, Rüdiger Köhling & Timo Kirschstein. (2020) Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity. Brain Sciences 10:2, pages 123.
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José Fidel Baizabal-Carvallo. (2019) The neurological syndromes associated with glutamic acid decarboxylase antibodies. Journal of Autoimmunity 101, pages 35-47.
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José Fidel Baizabal-Carvallo & Marlene Alonso-Juarez. 2019. Neuroimmune Diseases. Neuroimmune Diseases 621 649 .
Suvi Liimatainen, Jerome Honnorat, Sean J. Pittock, Andrew McKeon, Mario Manto, Jared R. Radtke & Christiane S. Hampe. (2018) GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies. Orphanet Journal of Rare Diseases 13:1.
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J. Triplett, S. Vijayan, A. MacDonald, N. Lawn, A. McLean-Tooke, M. Bynevelt, C. Phatouros & T. Chemmanam. (2018) Fulminant Anti-GAD antibody encephalitis presenting with status epilepticus requiring aggressive immunosuppression. Journal of Neuroimmunology 323, pages 119-124.
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Hiroshi Mitoma, Mario Manto & Christiane S. Hampe. (2017) Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias. Journal of Immunology Research 2017, pages 1-12.
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Carolyn A. Fredericks & Michael D. Geschwind. 2016. The Behavioral Neurology of Dementia. The Behavioral Neurology of Dementia 365 399 .
Jana K. Hackert, Lorenz Müller, Marco Rohde, Christian G. Bien, Rüdiger Köhling & Timo Kirschstein. (2016) Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission. Frontiers in Cellular Neuroscience 10.
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Jeffrey Britton. 2016. Autoimmune Neurology. Autoimmune Neurology 219 245 .
Nelly Stemmler, Karin Rohleder, Michael P. Malter, Guido Widman, Christian E. Elger, Heinz Beck & Rainer Surges. (2015) Serum from a Patient with GAD65 Antibody-Associated Limbic Encephalitis Did Not Alter GABAergic Neurotransmission in Cultured Hippocampal Networks. Frontiers in Neurology 6.
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José Fidel Baizabal-Carvallo & Joseph Jankovic. (2015) Stiff-person syndrome: insights into a complex autoimmune disorder. Journal of Neurology, Neurosurgery & Psychiatry 86:8, pages 840-848.
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M.P. Malter, C. Frisch, H. Zeitler, R. Surges, H. Urbach, C. Helmstaedter, C.E. Elger & C.G. Bien. (2015) Treatment of immune-mediated temporal lobe epilepsy with GAD antibodies. Seizure 30, pages 57-63.
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Holger Haselmann, Luise Röpke, Christian Werner, Albrecht Kunze & Christian Geis. (2015) Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission – Analyzing Antibody-Induced Effects ex vivo. Frontiers in Neurology 6.
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M. Loredana Marcovecchio, Marianna Immacolata Petrosino & Francesco Chiarelli. (2015) Diabetes and Epilepsy in Children and Adolescents. Current Diabetes Reports 15:4.
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Laura Licchetta, Francesca Bisulli, Ilaria Naldi, Greta Mainieri & Paolo Tinuper. (2014) Limbic encephalitis with anti‐GAD antibodies and Thomsen myotonia: a casual or causal association?. Epileptic Disorders 16:3, pages 362-365.
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Jan Bauer, Bethan Lang, Sarosh R. Irani & Annamaria Vezzani. 2014. Neuroinflammation and CNS Disorders. Neuroinflammation and CNS Disorders 289 315 .
Marinos C. Dalakas. (2013) Progress and stiff challenges in understanding the role of GAD-antibodies in stiff-person syndrome. Experimental Neurology 247, pages 303-307.
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Alberto Verrotti, Alessandra Scaparrotta, Cristina Olivieri & Francesco Chiarelli. (2012) MECHANISMS IN ENDOCRINOLOGY: Seizures and type 1 diabetes mellitus: current state of knowledge. European Journal of Endocrinology 167:6, pages 749-758.
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Madeleine Sharp & Manouchehr Javidan. (2014) Immunomodulation in Adult Epilepsy: The Role of IVIG. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 39:5, pages 584-591.
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Maike Gold, Refik Pul, Jan-Philipp Bach, Martin Stangel & Richard Dodel. (2012) Pathogenic and physiological autoantibodies in the central nervous system. Immunological Reviews 248:1, pages 68-86.
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Goran Rakocevic & Mary Kay Floeter. (2012) Autoimmune stiff person syndrome and related myelopathies: Understanding of electrophysiological and immunological processes. Muscle & Nerve 45:5, pages 623-634.
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Luca Errichiello, Salvatore Striano, Federico Zara & Pasquale Striano. (2011) Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity. Neurological Sciences 32:4, pages 547-550.
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Harry Alexopoulos & Marinos C. Dalakas. (2010) A critical update on the immunopathogenesis of Stiff Person Syndrome. European Journal of Clinical Investigation 40:11, pages 1018-1025.
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Charlotte J. Stagg, Bethan Lang, Jonathan G. Best, Karen McKnight, Ana Cavey, Heidi Johansen‐Berg, Angela Vincent & Jacqueline Palace. (2010) Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels. Epilepsia 51:9, pages 1898-1901.
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Suvi Liimatainen, Maria Peltola, Lidia Sabater, Mahdi Fallah, Elham Kharazmi, Anna‐Maija Haapala, Prasun Dastidar, Mikael Knip, Albert Saiz & Jukka Peltola. (2010) Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy. Epilepsia 51:5, pages 760-767.
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Angela Vincent, Sarosh R Irani & Bethan Lang. (2010) The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins. Current Opinion in Neurology 23:2, pages 144-150.
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Michael P. Malter, Christoph Helmstaedter, Horst Urbach, Angela Vincent & Christian G. Bien. (2010) Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Annals of Neurology 67:4, pages 470-478.
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