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Immunopharmacology and Immunotoxicology Volume 42, 2020 - Issue 2
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Original Articles

Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells

Asuman Deveci OzkanDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-3248-4279View further author information
ORCID Icon,
Suleyman KaleliDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey; ORCID Iconhttp://orcid.org/0000-0002-6043-2521View further author information
ORCID Icon,
Hacer Ilke OnenDepartment of Medical Biology, Faculty of Medicine, Gazi University, Ankara, Turkey; ORCID Iconhttp://orcid.org/0000-0002-7220-0066View further author information
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Mehmet SarihanDepartment of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey; View further author information
,
Gamze Guney EskilerDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey; ORCID Iconhttp://orcid.org/0000-0002-2088-9914View further author information
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Aysel Kalayci YiginDepartment of Medical Genetic, Cerrahpaşa Medical Faculty, İstanbul University, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0001-8549-5564View further author information
ORCID Icon &
Mehmet AkdoganDepartment of Medical Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, TurkeyORCID Iconhttp://orcid.org/0000-0003-2089-0082View further author information
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Pages 93-100 | Received 17 Oct 2019, Accepted 25 Jan 2020, Published online: 12 Feb 2020

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Yun-Yi Chen, Jiao-Jiao Liang, Deng-Liang Wang, Jie-Biao Chen, Jin-Ping Cao, Yue Wang & Chong-De Sun. (2023) Nobiletin as a chemopreventive natural product against cancer, a comprehensive review. Critical Reviews in Food Science and Nutrition 63:23, pages 6309-6329.
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Rizwan Arshad, Saira Masood, Hafiz Rizwan Sharif, Gulden Goksen, Baojun Xu & Muhammad Faisal Manzoor. (2023) New Insights into Health-Promoting Effects of Nobiletin from Citrus Fruits. Food Reviews International 0:0, pages 1-20.
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Qiong Peng, Yao Zhang, Mingxuan Zhu, Feng Bao, Jing Deng & Wen Li. (2022) Polymethoxyflavones from citrus peel: advances in extraction methods, biological properties, and potential applications. Critical Reviews in Food Science and Nutrition 0:0, pages 1-13.
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Asuman Deveci Ozkan, Mehmet Sarihan & Suleyman Kaleli. (2021) Evaluation of the Effects of Nobiletin on Toll-Like Receptor 3 Signaling Pathways in Prostate Cancer In Vitro. Nutrition and Cancer 73:7, pages 1138-1144.
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Alok P Singh, Jai B Kandpal, Rajeev K Sharma & Havagiray Chitme. (2021) Nobiletin a Biologically Active Phytoconstituent: Systematic Review. Journal of Biologically Active Products from Nature 11:3, pages 204-211.
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Articles from other publishers (21)

Eunju Kim, Kazuaki Mawatari, Seung-Hee Yoo & Zheng Chen. (2023) The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes. Nutrients 15:18, pages 3919.
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Ji Hye Lee, Yon-Suk Kim & Kang Hyun Leem. (2023) Citri Reticulatae Pericarpium Limits TLR-4-Triggered Inflammatory Response in Raw264.7 Macrophages by Activating RasGRP3. International Journal of Molecular Sciences 24:18, pages 13777.
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Yu Wang, Haidong Guo & Feng He. (2022) Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets. Cancer and Metastasis Reviews 42:1, pages 297-322.
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Marta Oleszek, Iwona Kowalska, Terenzio Bertuzzi & Wiesław Oleszek. (2023) Phytochemicals Derived from Agricultural Residues and Their Valuable Properties and Applications. Molecules 28:1, pages 342.
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Shuo LI, Guifang FAN, Xiaojiaoyang LI, Yajie CAI & Runping LIU. (2023) Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases. Chinese Journal of Natural Medicines 21:1, pages 3-18.
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Zeyuan Zheng, Jinxin Li, Yankuo Liu, Zhiyuan Shi, Zuodong Xuan, Kunao Yang, Chunlan Xu, Yang Bai, Meiling Fu, Qiaohong Xiao, Huimin Sun & Chen Shao. (2022) The Crucial Role of AR-V7 in Enzalutamide-Resistance of Castration-Resistant Prostate Cancer. Cancers 14:19, pages 4877.
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Fu Peng, Minru Liao, Rui Qin, Shiou Zhu, Cheng Peng, Leilei Fu, Yi Chen & Bo Han. (2022) Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Signal Transduction and Targeted Therapy 7:1.
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Zhiyi Lu & Fengyin Sun. (2022) Downregulated TICAM1 is a prognostic biomarker and associated with immune tolerance of Wilms tumor patients. BMC Medical Genomics 15:1.
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Weiwei Li, Yunzhi Tan, Feng Gao & Miaomiao Xiang. (2021) Overexpression of TRIM3 protects against LPS-induced acute kidney injury via repressing IRF3 pathway and NLRP3 inflammasome. International Urology and Nephrology 54:6, pages 1331-1342.
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Jun Huang, Zaoshang Chang, Quzhe Lu, Xuedong Chen & Masoud Najafi. (2022) Nobiletin as an inducer of programmed cell death in cancer: a review. Apoptosis 27:5-6, pages 297-310.
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Lijie Gu, Zhifang Wang, Yueyue Zhang, Nan Zhu, Jiayong Li, Man Yang, Ling Wang & Shu Rong. (2022) TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease. Cell Proliferation 55:3.
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Gamze Guney Eskiler & Asuman Deveci Özkan. (2022) The relationship between the efficacy of talazoparib and the functional toll-like receptors 3 and 9 in triple negative breast cancer. Molecular Immunology 141, pages 280-286.
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Bernard W DownsSamudra P. BanikManashi BagchiBruce S. MorrisonSteve W. KushnerMatt PiacentinoDebasis Bagchi. (2021) Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation. American Journal of Biopharmacy and Pharmaceutical Sciences 1, pages 2.
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Yuan Liu, Cuifu Yu, Zhenlong Shao, Xiaohong Xia, Tumei Hu, Weiyao Kong, Xiaoyue He, Wenshuang Sun, Yuanfei Deng, Yuning Liao & Hongbiao Huang. (2021) Selective degradation of AR-V7 to overcome castration resistance of prostate cancer. Cell Death & Disease 12:10.
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Yoshitaka Hosokawa, Ikuko Hosokawa & Kazumi Ozaki. (2021) Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells. Mediators of Inflammation 2021, pages 1-7.
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Burcu YÜKSEL & Asuman DEVECİ ÖZKAN. (2021) The Role of Citrus Nobiletin on Oxidative Stress Levels and Superoxide Dismutase Activities in Metastatic Castration-Resistant Prostate Cancer. Commagene Journal of Biology, pages 84-89.
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Chao Li, Junhui Wang, Mailiang Zhao, Sheng Zhang & Yanwei Zhang. (2021) Toll‐like receptor 4 antagonist FP7 alleviates lipopolysaccharide‐induced septic shock via NF‐kB signaling pathway. Chemical Biology & Drug Design 97:6, pages 1151-1157.
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Alena Liskova, Marek Samec, Lenka Koklesova, Samson M. Samuel, Kevin Zhai, Raghad Khalid Al-Ishaq, Mariam Abotaleb, Vladimir Nosal, Karol Kajo, Milad Ashrafizadeh, Ali Zarrabi, Aranka Brockmueller, Mehdi Shakibaei, Peter Sabaka, Ioana Mozos, David Ullrich, Robert Prosecky, Giampiero La Rocca, Martin Caprnda, Dietrich Büsselberg, Luis Rodrigo, Peter Kruzliak & Peter Kubatka. (2021) Flavonoids against the SARS-CoV-2 induced inflammatory storm. Biomedicine & Pharmacotherapy 138, pages 111430.
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Selen GÜÇLÜ DURGUN & Asuman DEVECİ ÖZKAN. (2021) Bağırsak Mikrobiyotası ve Toll Benzeri Reseptörler Arasındaki İlişki: Bağışıklık ve MetabolizmaThe Relationship Between Intestinal Microbiota and Toll-Like Receptors: Immunity and Metabolism. Journal of Biotechnology and Strategic Health Research 5:1, pages 12-21.
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Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Shahid Raza, Bahare Salehi, William C. Cho, Javad Sharifi-Rad, Wojciech Koch, Wirginia Kukula-Koch, Anna Głowniak-Lipa & Paweł Helon. (2021) MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer. Frontiers in Pharmacology 11.
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Milad Ashrafizadeh, Ali Zarrabi, Sedigheh Saberifar, Farid Hashemi, Kiavash Hushmandi, Fardin Hashemi, Ebrahim Rahmani Moghadam, Reza Mohammadinejad, Masoud Najafi & Manoj Garg. (2020) Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways. Biomedicines 8:5, pages 110.
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