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Immunopharmacology and Immunotoxicology Volume 42, 2020 - Issue 6
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Original Articles

Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages

Jianping Shenga Department of General Surgery, the People’s Hospital of Yuhuan, Taizhou, ChinaView further author information
,
Baohang Zhanga Department of General Surgery, the People’s Hospital of Yuhuan, Taizhou, ChinaView further author information
,
Yongfeng Chena Department of General Surgery, the People’s Hospital of Yuhuan, Taizhou, ChinaView further author information
&
Fuxiang Yub Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaCorrespondence[email protected]
View further author information
Pages 556-563 | Received 29 Apr 2020, Accepted 09 Aug 2020, Published online: 21 Oct 2020

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Wen Zhao, Huimin Zhang, Rui Liu & Rongtao Cui. (2023) Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation. International Journal of Nanomedicine 18, pages 3643-3662.
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Qiongdan Hu, Wan Liao, Zhen Zhang, Sanjun Shi, Shuguang Hou, Ningping Ji, Xinjie Zhang, Qian Zhang, Yangyang Liao, Linghui Li, Zongping Zhu, Yi Chen, Jiao Chen, Fangkun Yu, Qingsong Yang, Hongtao Xiao, Chaomei Fu, Hengjun Du, Qi Wang, Heping Cao, Hang Xiao & Rui Li. (2023) The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: a prospective review. Critical Reviews in Food Science and Nutrition 63:28, pages 9136-9162.
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Articles from other publishers (16)

Quanquan Cao, Hongying Shan, Ju Zhao, Jinhe Deng, Man Xu, Hao Kang, Tong Li, Ye Zhao, Haifeng Liu & Jun Jiang. (2023) Liver fibrosis in fish research: From an immunological perspective. Fish & Shellfish Immunology 139, pages 108885.
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Ming yun Yu, Hui jie Jia, Jing Zhang, Guang he Ran, Yan Liu & Xiu hong Yang. (2023) Exosomal miRNAs-mediated macrophage polarization and its potential clinical application. International Immunopharmacology 117, pages 109905.
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Wenjuan Xu, Longde Wang, Yuanyuan Niu, Lanfang Mao, Xiaojuan Du, Ping Zhang, Zhengju Li, Hongfang Li & Ning Li. (2022) A review of edible plant-derived natural compounds for the therapy of liver fibrosis. European Journal of Gastroenterology & Hepatology 35:2, pages 133-152.
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Xianhong Xiao & Qiang Zhang. (2022) Asiaticoside conveys an antifibrotic effect by inhibiting activation of hepatic stellate cells via the Jagged-1/Notch-1 pathway. Journal of Natural Medicines 77:1, pages 128-136.
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Tan Khanh Nguyen, Huy Hieu Phung, Won Jun Choi & Hee-Chul Ahn. (2022) Network Pharmacology and Molecular Docking Study on the Multi-Target Mechanisms of Aloe vera for Non-Alcoholic Steatohepatitis Treatment. Plants 11:24, pages 3585.
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Shuaibing He, Yanfeng Yi, Diandong Hou, Xuyan Fu, Juan Zhang, Xiaochen Ru, Jinlu Xie & Juan Wang. (2022) Identification of hepatoprotective traditional Chinese medicines based on the structure–activity relationship, molecular network, and machine learning techniques. Frontiers in Pharmacology 13.
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Zhenyu Liu, Weili Wang, Xueqin Li, Sha Tang, Dongwei Meng, Wenli Xia, Hong Wang, Yuzhang Wu, Xinyuan Zhou & Jingbo Zhang. (2022) Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1–Smad2/3 signaling. Phytomedicine 100, pages 154067.
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Enrico Conte. (2022) Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches. Pharmacology & Therapeutics 234, pages 108031.
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Zoufang Huang, Mohit Sharma, Aparna Dave, Yuqi Yang, Zhe-Sheng Chen & Raghu Radhakrishnan. (2022) The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis. Frontiers in Pharmacology 13.
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Wenyan Chen, Yining Liu, Jing Chen, Yawen Song, Mingdan You & Guanghong Yang. (2022) Long-term co-exposure DBP and BaP causes imbalance in liver macrophages polarization via activation of Notch signaling regulated by miR-34a-5p in rats. Chemico-Biological Interactions 359, pages 109919.
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Jessica Knoell, Shashi Chillappagari, Lars Knudsen, Martina Korfei, Ruth Dartsch, Danny Jonigk, Mark P. Kuehnel, Konrad Hoetzenecker, Andreas Guenther & Poornima Mahavadi. (2022) PACS2–TRPV1 axis is required for ER–mitochondrial tethering during ER stress and lung fibrosis. Cellular and Molecular Life Sciences 79:3.
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Cheng Wang, Cheng Ma, Lihong Gong, Yuqin Guo, Ke Fu, Yafang Zhang, Honglin Zhou & Yunxia Li. (2021) Macrophage Polarization and Its Role in Liver Disease. Frontiers in Immunology 12.
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Hao Xu & Lin Wang. (2021) The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease. Frontiers in Molecular Biosciences 8.
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Jinhang Zhang, Qinhui Liu, Jinhan He & Yanping Li. (2021) Novel Therapeutic Targets in Liver Fibrosis. Frontiers in Molecular Biosciences 8.
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Wenyan Chen, Yining Liu, Jing Chen, Yemei Ma, Yawen Song, Yanli Cen, Mingdan You & Guanghong Yang. (2021) The Notch signaling pathway regulates macrophage polarization in liver diseases. International Immunopharmacology 99, pages 107938.
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Shanshan Chen, Xuan Dai, Hong Li, Yuhan Gong, Yueyue Zhao & Haijun Huang. (2021) Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. Human Cell 34:3, pages 759-770.
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