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Immunopharmacology and Immunotoxicology Volume 43, 2021 - Issue 1
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Statins as an adjunctive therapy for COVID-19: the biological and clinical plausibility

Tarek Kashoura Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University Medical City, King Saud University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0003-0494-3746
ORCID Icon,
Rabih Halwanib Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, UAE
,
Yaseen M. Arabic Intensive Care Department, Ministry of National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia;d King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
,
M. Rizwan Sohaile Section of Infectious Diseases, Baylor College of Medicine Houston, TX, USA;;f Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA
,
John C. O’Horof Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA;g Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA
,
Andrew D. Badleyf Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA;h Department of Molecular Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA
&
Imad M. Tleyjehf Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA;i Division of Epidemiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA;j Department of Medical Specialties, Infectious Diseases Section, King Fahad Medical City, Riyadh, Saudi Arabia;k College of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5551-0353
ORCID Icon show all
Pages 37-50 | Received 18 Sep 2020, Accepted 07 Dec 2020, Published online: 06 Jan 2021

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Raffaella Mormile. (2022) Il-6, Il-1β and cytokine-targeted therapy for COVID -19 patients: two more reasons to take into account statins?. Expert Review of Cardiovascular Therapy 20:3, pages 161-163.
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Articles from other publishers (13)

Hu Meng, Arjun Sengupta, Emanuela Ricciotti, Antonijo Mrčela, Divij Mathew, Liudmila L. Mazaleuskaya, Soumita Ghosh, Thomas G. Brooks, Alexandra P. Turner, Alessa Soares Schanoski, Nicholas F. Lahens, Ai Wen Tan, Ashley Woolfork, Greg Grant, Katalin Susztak, Andrew G. Letizia, Stuart C. Sealfon, E. John Wherry, Krzysztof Laudanski, Aalim M. Weljie, Nuala J. Meyer & Garret A. FitzGerald. (2023) Deep phenotyping of the lipidomic response in COVID‐19 and non‐COVID‐19 sepsis. Clinical and Translational Medicine 13:11.
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Massimo Granai, Verena Warm, Antonio Vogelsberg, Jakob Milla, Karen Greif, Ulrich Vogel, Tamam Bakchoul, Peter Rosenberger, Leticia Quintanilla-Martinez, Christian M. Schürch, Karin Klingel, Falko Fend & Hans Bösmüller. (2023) Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19. Laboratory Investigation 103:8, pages 100179.
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Ettore Crimi, Umme Rumana, Darwin N. Ang, Cristobal Cintron, Katarina Kapisoda, William Zeleznak, Liu Huazhi, Massimiliano Galdiero & Claudio Napoli. (2023) Beneficial effects of prehospital use of statins in a large United States cohort of hospitalized coronavirus disease 2019 patients. Journal of Cardiovascular Medicine 24:3, pages 172-183.
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Eduardo Barge-Caballero, Pedro J. Marcos-Rodríguez, Nieves Domenech-García, Germán Bou-Arévalo, Javier Cid-Fernández, Raquel Iglesias-Reinoso, Paula López-Vázquez, Javier Muñiz, José M. Vázquez-Rodríguez & María G. Crespo-Leiro. (2023) Impacto del tratamiento previo con estatinas sobre la supervivencia de los pacientes hospitalizados con COVID-19. Medicina Clínica 160:1, pages 1-9.
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Eduardo Barge-Caballero, Pedro J. Marcos-Rodríguez, Nieves Domenech-García, Germán Bou-Arévalo, Javier Cid-Fernández, Raquel Iglesias-Reinoso, Paula López-Vázquez, Javier Muñiz, José M. Vázquez-Rodríguez & María G. Crespo-Leiro. (2023) Survival impact of previous statin therapy in patients hospitalized with COVID-19. Medicina Clínica (English Edition) 160:1, pages 1-9.
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Marta Di Simone, Anna Maria Corsale, Elena Lo Presti, Nicola Scichilone, Carmela Picone, Lydia Giannitrapani, Francesco Dieli & Serena Meraviglia. (2022) Phenotypical and Functional Alteration of γδ T Lymphocytes in COVID-19 Patients: Reversal by Statins. Cells 11:21, pages 3449.
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Francisco J. Barrantes. (2022) The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection. Progress in Lipid Research 87, pages 101166.
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Chengyu Liu, Wanyao Yan, Jiajian Shi, Shun Wang, Anlin Peng, Yuchen Chen & Kun Huang. (2022) Biological Actions, Implications, and Cautions of Statins Therapy in COVID-19. Frontiers in Nutrition 9.
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Ali A. El-Solh, Yolanda Lawson & Daniel A. El-Solh. (2021) All-cause mortality in COVID-19 patients receiving statin therapy: analysis of veterans affairs database cohort study. Internal and Emergency Medicine 17:3, pages 685-694.
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Stéphane Orlowski, Jean-Jacques Mourad, Antonio Gallo & Eric Bruckert. (2021) Coronaviruses, cholesterol and statins: Involvement and application for Covid-19. Biochimie 189, pages 51-64.
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Safwaan Adam, Jan Hoong Ho, Bilal Bashir, Zohaib Iqbal, Maryam Ferdousi, Akheel A. Syed & Handrean Soran. (2021) The impact of atherosclerotic cardiovascular disease, dyslipidaemia and lipid lowering therapy on Coronavirus disease 2019 outcomes: an examination of the available evidence. Current Opinion in Lipidology 32:4, pages 231-243.
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Mariana Alves, Marília Andreia Fernandes, Gülistan Bahat, Athanase Benetos, Hugo Clemente, Tomasz Grodzicki, Manuel Martínez-Sellés, Francesco Mattace-Raso, Chakravarthi Rajkumar, Andrea Ungar, Nikos Werner, Timo E. Strandberg, Grodzicki & Strandberg. (2021) Protecting older patients with cardiovascular diseases from COVID-19 complications using current medications. European Geriatric Medicine 12:4, pages 725-739.
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Zachary A Yetmar, Supavit Chesdachai, Tarek Kashour, Muhammad Riaz, Danielle J Gerberi, Andrew D Badley, Elie F Berbari & Imad M Tleyjeh. (2021) Prior Statin Use and Risk of Mortality and Severe Disease From Coronavirus Disease 2019: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases 8:7.
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