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Immunopharmacology and Immunotoxicology Volume 43, 2021 - Issue 2
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Original Articles

Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway

Nageh Ahmed El-MahdyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt
,
Magda El-Sayed El-SayadDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt
,
Aya Hassan El-KademDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-7915-0949
ORCID Icon &
Sally EL-Sayed Abu-RishaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt
Pages 192-202 | Received 13 Jul 2020, Accepted 09 Jan 2021, Published online: 27 Jan 2021

Citations (11)

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Huan Lin, Haiyong Ao, Guanghua Guo & Mingzhuo Liu. (2023) The Role and Mechanism of Metformin in Inflammatory Diseases. Journal of Inflammation Research 16, pages 5545-5564.
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Articles from other publishers (10)

Khaled Naja, Najeha Anwardeen, Moustafa Al-Hariri, Asmaa A. Al Thani & Mohamed A. Elrayess. (2023) Pharmacometabolomic Approach to Investigate the Response to Metformin in Patients with Type 2 Diabetes: A Cross-Sectional Study. Biomedicines 11:8, pages 2164.
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Fei Zou, Su Wang, Mengmeng Xu, Zengrong Wu & Feihong Deng. (2023) The role of sphingosine-1-phosphate in the gut mucosal microenvironment and inflammatory bowel diseases. Frontiers in Physiology 14.
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Xueliang Yi, Xuemei Tang, Tianlong Li, Lin Chen, Hongli He, Xiaoxiao Wu, Chunlin Xiang, Min Cao, Zixiang Wang, Yi Wang, Yiping Wang & Xiaobo Huang. (2023) Therapeutic potential of the sphingosine kinase 1 inhibitor, PF-543. Biomedicine & Pharmacotherapy 163, pages 114401.
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Kareman M. El-Beheiry, Magda El-Sayed El-Sayad, Thanaa A. El-Masry & Alaa E. Elsisi. (2023) Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway. International Immunopharmacology 117, pages 109891.
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Alaa Bagalagel, Reem Diri, Ahmad Noor, Deina Almasri, Hussain T. Bakhsh, Hussam I. Kutbi & Mohammed M. H. Al‐Gayyar. (2022) The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP‐1α/miR‐143 signalling. Basic & Clinical Pharmacology & Toxicology 131:5, pages 406-419.
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Wasuwit Wanchaitanawong, Nithi Thinrungroj, Siriporn C. Chattipakorn, Nipon Chattipakorn & Krekwit Shinlapawittayatorn. (2022) Repurposing metformin as a potential treatment for inflammatory bowel disease: Evidence from cell to the clinic. International Immunopharmacology 112, pages 109230.
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Amin Hasanvand. (2022) The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases. Inflammopharmacology 30:3, pages 775-788.
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Nashwah G. M. Attallah, Suzy A. El-Sherbeni, Aya H. El-Kadem, Engy Elekhnawy, Thanaa A. El-Masry, Elshaymaa I. Elmongy, Najla Altwaijry & Walaa A. Negm. (2022) Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities. Molecules 27:4, pages 1329.
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Moein Ala & Mahan Ala. (2021) Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?. ACS Pharmacology & Translational Science 4:6, pages 1747-1770.
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Mahmoud E. Youssef, Eslam E. Abd El-Fattah, Amir M. Abdelhamid, Hanan Eissa, Eman El-Ahwany, Noha A. Amin, Helal F. Hetta, Mohamed H. Mahmoud, Gaber El-Saber Batiha, Naglaa Gobba, Ahmed Gaafar Ahmed Gaafar & Sameh Saber. (2021) Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis. Frontiers in Pharmacology 12.
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