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Immunopharmacology and Immunotoxicology Volume 43, 2021 - Issue 3
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Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19

Ali Saeedi-Boroujenia Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;b Abadan School of Medical Sciences, Abadan, Iran;c Immunology Today, Universal Scientific Education and Research Network (USERN), Tehran, IranView further author information
,
Mohammad-Reza Mahmoudian-Sanid Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranView further author information
,
Roohangiz Nashibie Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;f Infectious Diseases & Tropical Medicine Ward, Razi Teaching Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranView further author information
,
Sheyda Houshmandfara Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranView further author information
,
Sima Tahmaseby Gandomkarid Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranView further author information
&
Ali Khodadadia Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence[email protected], [email protected]
View further author information
Pages 247-258 | Received 20 Apr 2020, Accepted 23 Apr 2021, Published online: 21 May 2021

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Karim Mahnam & Zahra Ghobadi. (2022) Finding a prospective dual-target drug for the treatment of coronavirus disease by theoretical study. Journal of Biomolecular Structure and Dynamics 40:23, pages 12621-12641.
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Articles from other publishers (14)

Xiaolu Zhang, Ziyu Wang, Yujia Zheng, Qun Yu, Miao Zeng, Liding Bai, Lin Yang, Maojuan Guo, Xijuan Jiang & Jiali Gan. (2023) Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review). International Journal of Molecular Medicine 51:4.
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Kamini, Anoop Kumar, Pooja A. Chawla & Bhupinder Kapoor. 2023. Recent Developments in Anti-Inflammatory Therapy. Recent Developments in Anti-Inflammatory Therapy 331 386 .
Pooya Farhangnia, Amir Reza Safdarian & Mahzad Akbarpour. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 42 .
Jun-Feng Cao, Yunli Gong, Mei Wu, Li Xiong, Shengyan Chen, Haonan Huang, Xinge Zhou, Ying-chun Peng, Xue-fang Shen, Jinyu Qu, Yi-li Wang & Xiao Zhang. (2022) Molecular docking and molecular dynamics study Lianhua Qingwen granules (LHQW) treats COVID-19 by inhibiting inflammatory response and regulating cell survival. Frontiers in Cellular and Infection Microbiology 12.
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Giuseppe Palma, Gian Pio Sorice, Valentina Annamaria Genchi, Fiorella Giordano, Cristina Caccioppoli, Rossella D’Oria, Nicola Marrano, Giuseppina Biondi, Francesco Giorgino & Sebastio Perrini. (2022) Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity. International Journal of Molecular Sciences 23:13, pages 7349.
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Wael Alkattan, Ahmed Yaqinuddin, Areez Shafqat & Junaid Kashir. (2022) NET-Mediated Pathogenesis of COVID-19: The Role of NETs in Hepatic Manifestations. Journal of Health and Allied Sciences NU 12:03, pages 235-242.
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Davide Ferrari, Michele Rubini & Jorge S. Burns. (2022) The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2. Frontiers in Immunology 13.
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Hongning Jia, Xiaoyuan Qi, Lan Fu, Huijun Wu, Jinxing Shang, Mingwei Qu, Chaoping Yang & Jianping Wang. (2022) NLRP3 inflammasome inhibitor ameliorates ischemic stroke by reprogramming the phenotype of microglia/macrophage in a murine model of distal middle cerebral artery occlusion . Neuropathology 42:3, pages 181-189.
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Ali Saeedi-Boroujeni, Roohangiz Nashibi, Ata A. Ghadiri, Motowo Nakajima, Shokrollah Salmanzadeh, Mohammad-Reza Mahmoudian-Sani, Mohammad Ghasem Hanafi, Asaad Sharhani & Ali Khodadadi. (2022) Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial. Archives of Medical Research 53:4, pages 368-377.
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Saiful Amin, Salma Aktar, Md. Mijanur Rahman & Mohammed Mehadi Hassan Chowdhury. (2022) NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity. Microbes and Infection 24:1, pages 104913.
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Khashayar Zafar-Mohammadi, Javad Poursamimi & Mahdi Atabaki. (2022) NLRP3 inflammasome activation and its inhibitory drugs in connection with COVID-19 infection. European Journal of Inflammation 20, pages 1721727X2211309.
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Umair MallickUmair Mallick. 2022. Cardiovascular Complications of COVID-19. Cardiovascular Complications of COVID-19 63 94 .
Azadeh Manayi, Seyed Mohammad Nabavi, Maryam Khayatkashani, Solomon Habtemariam & Hamid Reza Khayat Kashani. (2021) Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19. Molecular Biology Reports 48:12, pages 8221-8225.
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Amal Feiroze Farouk, Areez Shafqat, Shameel Shafqat, Junaid Kashir, Khaled Alkattan & Ahmed Yaqinuddin. (2021) COVID-19 associated cardiac disease: Is there a role of neutrophil extracellular traps in pathogenesis?. AIMS Molecular Science 8:4, pages 275-290.
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