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Research Article

Role of Reactive Oxygen Species in Hepatic Ischemia-Reperfusion Injury and Preconditioning

Pages 127-140 | Published online: 09 Jul 2009

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Saber Abdelkader Saidi, Ezzeddine Bourogâa, Amira Bouaziz, Saaoudi Mongi, Rim Chaaben, Kamel Jamoussi, Raoudha Mezghani-Jarraya, Jos van Pelt & Abdelfattah El-Feki. (2015) Protective effects of Hammada scoparia flavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion. Pharmaceutical Biology 53:12, pages 1810-1817.
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Xiao-Min Yao, Bao-Lian Wang, Hong-Yan Yu & Yan Li. (2011) Effects of bicyclol on the activity and expression of cytochrome P450 after hepatic warm ischemia/reperfusion in rats. Journal of Asian Natural Products Research 13:7, pages 634-644.
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Imam H. Shaik & Reza Mehvar. (2010) Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers. Free Radical Research 44:4, pages 441-453.
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Rafael Omar Giovanardi, Ernani Luis Rhoden, Carlos Thadeu Cerski, Miriam Salvador & Antonio Nocchi Kalil. (2009) Ischemic Preconditioning Protects the Pig Liver by Preserving the Mitochondrial Structure and Downregulating Caspase-3 Activity. Journal of Investigative Surgery 22:2, pages 88-97.
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Wen Zhang, Wenjie Fan, Xin Wang, Ping Li, Wei Zhang, Hui Wang & Bo Tang. (2023) Uncovering Endoplasmic Reticulum Superoxide Regulating Hepatic Ischemia-Reperfusion Injury by Dynamic Reversible Fluorescence Imaging. Analytical Chemistry 95:21, pages 8367-8375.
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Lianne R. de Haan, Megan J. Reiniers, Laurens F. Reeskamp, Ali Belkouz, Lei Ao, Shuqun Cheng, Baoyue Ding, Rowan F. van Golen & Michal Heger. (2022) Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox Status. Antioxidants 11:8, pages 1424.
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Samar G. Mohammed, Islam A.A.E.-H. Ibrahim, Mona F. Mahmoud & Amr A.A. Mahmoud. (2019) Carvedilol protects against hepatic ischemia/reperfusion injury in high-fructose/high-fat diet-fed mice: Role of G protein-coupled receptor kinase 2 and 5. Toxicology and Applied Pharmacology 382, pages 114750.
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Mona Fouad Mahmoud, Samar Gamal & Hassan M. El-Fayoumi. (2019) Baicalein Preconditioning Modulates Hepatocellular Injury following Liver Ischemia and Reperfusion in Rats via Anti-Inflammatory and Antioxidant Signaling. Dubai Medical Journal 2:2, pages 73-80.
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Vasantha L. Kolachala, Sirish K. Palle, Ming Shen, Asha Shenoi, Dmitry M. Shayakhmetov & Nitika A. Gupta. (2019) Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8. Hepatology Communications 3:7, pages 925-942.
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Yong Tang, Hongpeng Chu, Guojun Cao, Xiaolong Du, Xiaobo Min & Chidan Wan. (2018) S-Adenosylmethionine attenuates bile duct early warm ischemia reperfusion injury after rat liver transplantation. Molecular Immunology 95, pages 83-90.
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Camila G. Dossi, Daniel González-Mañán, Nalda Romero, David Silva, Luis A. Videla & Gladys S. Tapia. (2018) Anti-oxidative and anti-inflammatory effects of Rosa Mosqueta oil supplementation in rat liver ischemia-reperfusion. Food & Function 9:9, pages 4847-4857.
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Song Su, De Luo, Xiangdong Liu, Jiang Liu, Fangyi Peng, Cheng Fang & Bo Li. (2017) miR-494 up-regulates the PI3K/Akt pathway via targetting PTEN and attenuates hepatic ischemia/reperfusion injury in a rat model . Bioscience Reports 37:5.
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Yan-zhu Lin, Zhi-yuan Lu, Xiao-hui Liang, Kang Li, Bo Peng & Jin Gong. (2016) Effect of breviscapine against hepatic ischemia reperfusion injury. Journal of Surgical Research 203:2, pages 268-274.
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Lin Nanna Okholm Møller, Anders Riegels Knudsen, Kasper Jarlhelt Andersen, Jens Randel Nyengaard, Stephen Hamilton-Dutoit, Elise Marie Okholm Møller, Pia Svendsen, Holger Jon Møller, Søren Kragh Moestrup, Jonas Heilskov Graversen & Frank Viborg Mortensen. (2015) Anti-CD163-dexamethasone protects against apoptosis after ischemia/reperfusion injuries in the rat liver. Annals of Medicine and Surgery 4:4, pages 331-337.
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SA Saïdi, S Abdelkafi, S Jbahi, J van Pelt & A El-Feki. (2014) Temporal changes in hepatic antioxidant enzyme activities after ischemia and reperfusion in a rat liver ischemia model. Human & Experimental Toxicology 34:3, pages 249-259.
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Mabel Buelna-Chontal & Cecilia Zazueta. (2013) Redox activation of Nrf2 & NF-κB: A double end sword?. Cellular Signalling 25:12, pages 2548-2557.
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Shu-Jun Jiang Wen LiWei An. (2013) Adenoviral Gene Transfer of Hepatic Stimulator Substance Confers Resistance Against Hepatic Ischemia–Reperfusion Injury by Improving Mitochondrial Function. Human Gene Therapy 24:4, pages 443-456.
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Ahmed Taki-Eldin, Lin Zhou, Hai-Yang Xie, Kang-Jie Chen, Da Yu, Yong He & Shu-Sen Zheng. (2012) Triiodothyronine attenuates hepatic ischemia/reperfusion injury in a partial hepatectomy model through inhibition of proinflammatory cytokines, transcription factors, and adhesion molecules. Journal of Surgical Research 178:2, pages 646-656.
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Marcelo Mardones, Rodrigo Valenzuela, Pamela Romanque, Natalia Covarrubias, Fiorella Anghileri, Virginia Fernández, Luis A. Videla & Gladys Tapia. (2012) Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol. The Journal of Nutritional Biochemistry 23:9, pages 1113-1120.
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Qinlong Liu, Hasibur Rehman, Yanjun Shi, Yasodha Krishnasamy, John J. Lemasters, Charles D. Smith & Zhi Zhong. (2012) Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats. PLoS ONE 7:7, pages e41834.
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Kilian Weigand, Sylvia Brost, Niels Steinebrunner, Markus Büchler, Peter Schemmer & Martina Müller. (2012) Ischemia/Reperfusion Injury in Liver Surgery and Transplantation: Pathophysiology. HPB Surgery 2012, pages 1-8.
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Mona F. Mahmoud, Shimaa M. El Shazly & Waleed Barakat. (2012) Inhibition of TNF-α protects against hepatic ischemia–reperfusion injury in rats via NF-κB dependent pathway. Naunyn-Schmiedeberg's Archives of Pharmacology 385:5, pages 465-471.
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Sándor Bátkai, Partha Mukhopadhyay, Bėla Horváth, Mohanraj Rajesh, Rachel Y Gao, Anu Mahadevan, Mukkanti Amere, Natalia Battista, Aron H Lichtman, Lisa A Gauson, Mauro Maccarrone, Roger G Pertwee & Pál Pacher. (2012) Δ 8 ‐Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB 2 receptors . British Journal of Pharmacology 165:8, pages 2450-2461.
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Yanjun Shi, Hasibur Rehman, Venkat K. Ramshesh, Justin Schwartz, Qinlong Liu, Yasodha Krishnasamy, Xun Zhang, John J. Lemasters, Charles D. Smith & Zhi Zhong. (2012) Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia–reperfusion. Journal of Hepatology 56:1, pages 137-145.
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Venkateswaran C Pillai, Russell O Snyder, Upendra Gumaste, Thomas J Thekkumkara & Reza Mehvar. (2011) Effects of transient overexpression or knockdown of cytochrome P450 reductase on reactive oxygen species generation and hypoxia reoxygenation injury in liver cells. Clinical and Experimental Pharmacology and Physiology 38:12, pages 846-853.
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Zheng-Wei Ma, Xiao-Bin Feng, Shu-Guo Zheng, Ping Bie, Shu-Guang Wang, Kun Li, Yu-Jun Zhang & Jia-Hong Dong. (2011) Ethanol Preconditioning Reduces Hepatic I/R Injury by Inhibiting the Complement System Activation. Journal of Surgical Research 166:2, pages 314-323.
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Stephanie Peglow, Alexander H. Toledo, Roberto Anaya‐Prado, Fernando Lopez‐Neblina & Luis H. Toledo‐Pereyra. (2010) Allopurinol and xanthine oxidase inhibition in liver ischemia reperfusion. Journal of Hepato-Biliary-Pancreatic Sciences 18:2, pages 137-146.
Crossref
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Mahmoud Abu-Amara, Shi Yu Yang, Niteen Tapuria, Barry Fuller, Brian Davidson & Alexander Seifalian. (2010) Liver ischemia/reperfusion injury: Processes in inflammatory networks-A review. Liver Transplantation 16:9, pages 1016-1032.
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Keisuke Yamaguchi, Toshiyasu Kawahara, Seiichiro Kumakura, Jian Hua, Toyoki Kugimiya, Isao Nagaoka & Eiichi Inada. (2010) EFFECT OF OLPRINONE, A PHOSPHODIESTERASE III INHIBITOR, ON HEPATIC ISCHEMIA-REPERFUSION INJURY IN RATS. Shock 33:4, pages 436-441.
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Imam H. Shaik & Reza Mehvar. (2010) Effects of Cytochrome P450 Inhibition by Cimetidine on the Warm Hepatic Ischemia-Reperfusion Injury in Rats. Journal of Surgical Research 159:2, pages 680-688.
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Christian J. Steib & Alexander L. Gerbes. 2010. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 69 78 .
Rafael Omar Giovanardi, Ernani Luis Rhoden, Carlos Thadeu Cerski, Miriam Salvador & Antonio Nocchi Kalil. (2009) Pharmacological Preconditioning Using Intraportal Infusion of L-Arginine Protects Against Hepatic Ischemia Reperfusion Injury. Journal of Surgical Research 155:2, pages 244-253.
Crossref
Ji-Young Hong, Margitta Lebofsky, Anwar Farhood & Hartmut Jaeschke. (2009) Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH 2 -terminal kinase activation . American Journal of Physiology-Gastrointestinal and Liver Physiology 296:3, pages G572-G581.
Crossref
Niteen Tapuria, Sameer P. Junnarkar, Neelanjana Dutt, Mahmoud Abu-Amara, Barry Fuller, Alexander M. Seifalian & Brian R. Davidson. (2009) Effect of remote ischemic preconditioning on hepatic microcirculation and function in a rat model of hepatic ischemia reperfusion injury. HPB 11:2, pages 108-117.
Crossref
Zhi Zhong, Venkat K. Ramshesh, Hasibur Rehman, Robert T. Currin, Vijayalakshmi Sridharan, Tom P. Theruvath, Insil Kim, Gary L. Wright & John J. Lemasters. (2008) Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. American Journal of Physiology-Gastrointestinal and Liver Physiology 295:4, pages G823-G832.
Crossref
Imam H. Shaik, Jancy M. George, Thomas J. Thekkumkara & Reza Mehvar. (2008) Protective Effects of Diallyl Sulfide, a Garlic Constituent, on the Warm Hepatic Ischemia–Reperfusion Injury in a Rat Model. Pharmaceutical Research 25:10, pages 2231-2242.
Crossref
Samuel Wyllie, Neal R Barshes, Feng-Qin Gao, Saul J Karpen & John A Goss. (2008) Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver. World Journal of Gastroenterology 14:44, pages 6808.
Crossref
Hartmut Jaeschke. 2007. Textbook of Hepatology. Textbook of Hepatology 36 42 .
Hakan Canbaz, Tamer Akca, Canten Tataroglu, Mehmet Caglikulekci, Musa Dirlik, Lokman Ayaz, Ali Bora Ustunsoy, Bahar Tasdelen & Suha Aydin. (2007) The effects of exogenous l-carnitine on lipid peroxidation and tissue damage in an experimental warm hepatic ischemia-reperfusion injury model. Current Therapeutic Research 68:1, pages 32-46.
Crossref
Manfred Bilzer, Frigga Roggel & Alexander L. Gerbes. (2006) Role of Kupffer cells in host defense and liver disease. Liver International 26:10, pages 1175-1186.
Crossref
S. Tsuchihashi, F. Kaldas, N. Chida, Y. Sudo, K. Tamura, Y. Zhai, B. Qiao, R.W. Busuttil & J.W. Kupiec-Weglinski. (2006) FK330, a Novel Inducible Nitric Oxide Synthase Inhibitor, Prevents Ischemia and Reperfusion Injury in Rat Liver Transplantation. American Journal of Transplantation 6:9, pages 2013-2022.
Crossref
Matthias Behrends, Ryutaro Hirose, Natalie J. Serkova, John L. Coatney, Melanie Bedolli, Jason Yardi, Yeon Ho Park & Claus U. Niemann. (2006) Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats. Liver International 26:6, pages 734-741.
Crossref
Hana Cizova, Ivana Papezikova, Lukas Kubala, Antonin Lojek & Milan Ciz. (2006) Increased Antioxidant Capacity of Serum Did Not Prevent Lipid Peroxidation in the Intermittent Ischemia-Reperfusion of Rat Small Intestine. Digestive Diseases and Sciences 51:4, pages 657-661.
Crossref
Hartmut Jaeschke. 2006. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 37 51 .
Diego Bogetti, Howard N Sankary, Tomasz M Jarzembowski, Antonio Manzelli, Peter S Knight, James Thielke, Gregorio Chejfec, Scott Cotler, Jose Oberholzer, Giuliano Testa & Enrico Benedetti. (2005) Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury. Clinical Transplantation 19:4, pages 507-511.
Crossref
E. S. Baskin-Bey, A. Canbay, S. F. Bronk, N. Werneburg, M. E. Guicciardi, S. L. Nyberg & G. J. Gores. (2005) Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury. American Journal of Physiology-Gastrointestinal and Liver Physiology 288:2, pages G396-G402.
Crossref
D. Bogetti, T.M. Jarzembowski, H.N. Sankary, A. Manzelli, P.S. Knight, G. Chejfec, S. Cotler, J. Oberholzer, G. Testa & E. Benedetti. (2005) Hepatic ischemia/reperfusion injury can be modulated with thymoglobulin induction therapy. Transplantation Proceedings 37:1, pages 404-406.
Crossref
Manfred Bilzer & Alexander L. Gerbes. 2005. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 45 52 .

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