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Original Research

Differential Effect of Tacrolimus on Dermal and Intestinal Wound Healing

, MD, , MD, , MD, , MD, , MD & , MD
Pages 71-79 | Received 14 Sep 2004, Accepted 16 Nov 2004, Published online: 09 Jul 2009

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S. Akbulut, Z. Dogan, A. Baskiran, H. Elbe & Y. Turkoz. (2019) Effect of a honey and arginine-glutamine-hydroxymethylbutyrate mixture on the healing of colon anastomosis in rats immunosuppressed with tacrolimus. Biotechnic & Histochemistry 94:7, pages 514-521.
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Michael Schäffer, Martina Bongartz, Wolfgang Hoffmann & Richard Viebahn. (2006) Regulation of Nitric Oxide Synthesis in Wounds by IFN-γ Depends on TNF-α. Journal of Investigative Surgery 19:6, pages 371-379.
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Sulaiman Al-Hashmi, Saeid Vakilian, Fatemeh Jamshidi-adegani, Juhaina Al-Kindi, Fahad Al-Fahdi, Abdullah M.S. Al-Hatmi, Habib Al-Jahdhami, Muhammad U. Anwar, Nasar Al-Wahaibi, Asem Shalaby & Ahmed Al-Harrasi. (2023) Development of a Tacrolimus-loaded carboxymethyl chitosan scaffold as an effective 3D-printed wound dressing. Journal of Drug Delivery Science and Technology 86, pages 104707.
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Linxiumei Guo, Zhu Zhu, Chenchen Shi, Yuxin Jia, Yeltai Nurzat, Weijie Su, Yixin Zhang & Heng Xu. (2023) Drug suspending during wound healing effectively weakens immunosuppression‐related complications by preserving CD8 + T cell function . Wound Repair and Regeneration 31:4, pages 489-499.
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André Luís Conde WATANABE & Jorge Eduardo Fouto MATIAS. (2020) DOES THE ASSOCIATION OF TACROLIMUS AND MYCOPHENOLATE MOFETIL CHANGE THE HEALING OF THE ABDOMINAL WALL? STUDY IN RATS SUBMITTED TO ISCHEMIA AND KIDNEY REPERFUSION. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 33:4.
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Kalle Landerholm, Disa Kalman, Conny Wallon & Pär Myrelid. (2019) Immunomodulators: Friends or Enemies in Surgery for Crohn’s Disease?. Current Drug Targets 20:13, pages 1384-1398.
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Genshiro Esumi, Toshiharu Matsuura, Makoto Hayashida, Yoshiaki Takahashi, Koichiro Yoshimaru, Yusuke Yanagi, Mika Wada & Tomoaki Taguchi. (2019) Efficacy of Prophylactic Negative Pressure Wound Therapy After Pediatric Liver Transplant. Experimental and Clinical Transplantation 17:3, pages 381-386.
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Erdal UysalMehmet Dokur. (2017) Comparison of effects of the tacrolimus and cyclosporine A on the colon anastomosis recovery of rats. Annals of Surgical Treatment and Research 92:6, pages 402.
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Markus Alexander Küper, Sebastian Trütschel, Jürgen Weinreich, Alfred Königsrainer & Stefan Beckert. (2016) Growth hormone abolishes the negative effects of everolimus on intestinal wound healing. World Journal of Gastroenterology 22:17, pages 4321.
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Vinzent N. Spetzler, Nicolas Goldaracena, Max A. Marquez, Sunita K. Singh, Andrea Norgate, Ian D. McGilvray, Jeffrey Schiff, Paul D. Greig, Mark S. Cattral & Markus Selzner. (2015) Duodenal leaks after pancreas transplantation with enteric drainage - characteristics and risk factors. Transplant International 28:6, pages 720-728.
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Gustavo Marquesine Paul, Renato Tambara Filho & Jo?o Carlos Domingues Repka. (2014) Qualitative analysis of the deposit of collagen in bladder suture of rats treated with tacrolimus combined with mycophenolate-mofetil. International braz j urol 40:2, pages 257-265.
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Mohammed A. Alzoghaibi & Ahmed M. Zubaidi. (2014) Upregulation of the proinflammatory cytokine-induced neutrophil chemoattractant-1 and monocyte chemoattractant protein-1 in rats' intestinal anastomotic wound healing?Does it matter?. Asian Journal of Surgery 37:2, pages 86-92.
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Mari Nanna Øines. (2014) Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis. World Journal of Gastroenterology 20:35, pages 12637.
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Martine C. M. Willems, J. Adam van der Vliet, Roger M. L. M. Lomme & Thijs Hendriks. (2013) Tacrolimus Does Not Affect Early Wound Healing in a Rodent Model of Bowel Anastomoses and Abdominal Wall Closure. PLoS ONE 8:9, pages e76348.
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Victor W. Wong, Fanglei You, Michael Januszyk & Anna A. Kuang. (2013) Tacrolimus fails to regulate collagen expression in dermal fibroblasts. Journal of Surgical Research 184:1, pages 678-690.
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Sun Namkoong, Jimin Chung, Jiyeon Yoo, Minyoung Jung, Jiwon Gye, Ji Seok Kim, Jee Young Kim, Sung Ku Ahn, Byung Cheol Park, Myung Hwa Kim & Seung Phil Hong. (2013) Topical tacrolimus does not negatively impact acute skin wound healing. Experimental Dermatology 22:5, pages 369-371.
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Markus A. K?per, Nadja Sch?lzl, Frank Traub, Petra Mayer, J?rgen Weinreich, Stephan Coerper, Wolfgang Steurer, Alfred K?nigsrainer & Stefan Beckert. (2011) Everolimus Interferes with the Inflammatory Phase of Healing in Experimental Colonic Anastomoses. Journal of Surgical Research 167:1, pages 158-165.
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Jos? Mar?a Balibrea del Castillo, Javier Arias-D?az, Mar?a Cruz Garc?a Mart?n, Marta Vives-Pi, Juan Carlos Garc?a P?rez, Ram?n Cantero Cid, Elena Vara Ameigeiras & Jos? Luis Balibrea Cantero. (2010) Efecto citoprotector del tacrolimus a dosis bajas sobre islotes de Langeerhans en cultivo sometidos a est?mulos por citocinas del rechazo agudo. Cirug?a Espa?ola 87:6, pages 372-377.
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Ahmad Zubaidi, W. Donald Buie, David A. Hart & David Sigalet. (2009) Temporal Expression of Cytokines in Rat Cutaneous, Fascial, and Intestinal Wounds: A Comparative Study. Digestive Diseases and Sciences 55:6, pages 1581-1588.
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Jose M. Balibrea Del Castillo, M. Cruz García-Martín, Javier Arias-Díaz, Elena Giné, Elena Vara & Jose L. Balibrea Cantero. (2009) Antiapoptotic Effect of Tacrolimus on Cytokine-Challenged Human Islets. Cell Transplantation 18:10-11, pages 1237-1246.
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CLAUDIA HERNANDEZ, JASON EMER & JUNE K. ROBINSON. (2008) Perioperative Management of Medications for Psoriasis and Psoriatic Arthritis: A Review for the Dermasurgeon. Dermatologic Surgery 34:4, pages 446-459.
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CLAUDIA HERNANDEZ, JASON EMER & JUNE K. ROBINSON. (2008) Perioperative Management of Medications for Psoriasis and Psoriatic Arthritis. Dermatologic Surgery 34:4, pages 446-459.
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Tihomir Vuksic, Ivan Zoricic, Luka Brcic, Marko Sever, Robert Klicek, Bozo Radic, Vedran Cesarec, Lidija Berkopic, Neike Keller, Alenka Boban Blagaic, Neven Kokic, Ivan Jelic, Juraj Geber, Tomislav Anic, Sven Seiwerth & Predrag Sikiric. (2007) Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat. Surgery Today 37:9, pages 768-777.
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Michael Sch?ffer, Martina Bongartz, Wolfgang Hoffmann & Richard Viebahn. (2007) MHC-Class-II-Deficiency Impairs Wound Healing. Journal of Surgical Research 138:1, pages 100-105.
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Michael Schäffer, R. Schier, M. Napirei, S. Michalski, T. Traska & R. Viebahn. 2007. Chirurgisches Forum 2007. Chirurgisches Forum 2007 355 356 .
James Whiting. (2006) Perioperative Concerns for Transplant Recipients Undergoing Nontransplant Surgery. Surgical Clinics of North America 86:5, pages 1185-1194.
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Jolanda M. van Dieren, Ernst J. Kuipers, Janneke N. Samsom, Edward E. Nieuwenhuis & Janneke C. van der Woude. (2006) Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: Their mechanisms of action and role in the treatment of IBD. Inflammatory Bowel Diseases 12:4, pages 311-327.
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