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Journal of Investigative Surgery Volume 18, 2005 - Issue 4
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ORIGINAL RESEARCH

Validation of Rat Endometriosis Model by Using Raloxifene as a Positive Control for the Evaluation of Novel SERM Compounds

Z. Yao Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
X. Shen Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
I. Capodanno Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
M. Donnelly Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
J. Fenyk-Melody Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
J. Hausamann Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
C. Nunes Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
,
J. Strauss Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
&
K. Vakerich Merck Research Laboratories, Department of Laboratory, Animal Resources Rahway, New Jersey, USA
 show all
Pages 177-183 | Received 05 Jan 2005, Accepted 15 Mar 2005, Published online: 09 Jul 2009

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Sara Clemenza, Silvia Vannuccini, Agostino Ruotolo, Tommaso Capezzuoli & Felice Petraglia. (2022) Advances in targeting estrogen synthesis and receptors in patients with endometriosis. Expert Opinion on Investigational Drugs 31:11, pages 1227-1238.
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Laura Buggio, Dhouha Dridi, Giussy Barbara, Camilla E.M. Merli, Giulia Emily Cetera & Paolo Vercellini. (2022) Novel pharmacological therapies for the treatment of endometriosis. Expert Review of Clinical Pharmacology 15:9, pages 1039-1052.
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Vendy Zajec, Mislav Mikuš, Salvatore Giovanni Vitale, Maurizio Nicola D’alterio, Marija Gregov, Marko Jakov Šarić, Jose Carugno, Stefano Angioni & Mario Ćorić. (2022) Current status and challenges of drug development for hormonal treatment of endometriosis: a systematic review of randomized control trials. Gynecological Endocrinology 38:9, pages 713-720.
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Fabio Barra, Giovanni Grandi, Matteo Tantari, Carolina Scala, Fabio Facchinetti & Simone Ferrero. (2019) A comprehensive review of hormonal and biological therapies for endometriosis: latest developments. Expert Opinion on Biological Therapy 19:4, pages 343-360.
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Simone Ferrero, Giulio Evangelisti & Fabio Barra. (2018) Current and emerging treatment options for endometriosis. Expert Opinion on Pharmacotherapy 19:10, pages 1109-1125.
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Fabio Barra, Carolina Scala, Valerio Mais, Stefano Guerriero & Simone Ferrero. (2018) Investigational drugs for the treatment of endometriosis, an update on recent developments. Expert Opinion on Investigational Drugs 27:5, pages 445-458.
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Umberto Leone Roberti Maggiore & Simone Ferrero. (2016) An overview of early drug development for endometriosis. Expert Opinion on Investigational Drugs 25:2, pages 227-247.
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Ana Luiza L Rocha, Fernando M Reis & Felice Petraglia. (2012) New trends for the medical treatment of endometriosis. Expert Opinion on Investigational Drugs 21:7, pages 905-919.
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Isabelle Streuli, Dominique de Ziegler, Bruno Borghese, Pietro Santulli, Frédéric Batteux & Charles Chapron. (2012) New treatment strategies and emerging drugs in endometriosis. Expert Opinion on Emerging Drugs 17:1, pages 83-104.
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Sun-Wei Guo. (2008) Emerging drugs for endometriosis. Expert Opinion on Emerging Drugs 13:4, pages 547-571.
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Luigi Fedele, Edgardo Somigliana, Giada Frontino, Laura Benaglia & Paola Vigano. (2008) New drugs in development for the treatment of endometriosis. Expert Opinion on Investigational Drugs 17:8, pages 1187-1202.
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Attila Mihalyi, Peter Simsa, Kyama C Mutinda, Christel Meuleman, Jason M Mwenda & Thomas M D’Hooghe. (2006) Emerging drugs in endometriosis. Expert Opinion on Emerging Drugs 11:3, pages 503-524.
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Divya Chauhan, Pavan K Yadav, Nazneen Sultana, Arun Agarwal, Shailesh Dadge, Naveen Singh, Debalina Maity, Manish K Chourasia & Jiaur R Gayen. (2023) Simultaneous estimation of raloxifene and cladrin by HPLC: application to metabolic stability studies in different species. Bioanalysis 15:11, pages 601-620.
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Manuela Cristina Russu. 2022. Endometriosis - Recent Advances, New Perspectives and Treatments. Endometriosis - Recent Advances, New Perspectives and Treatments.
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Geraldine Brichant, Ines Laraki, Laurie Henry, Carine Munaut & Michelle Nisolle. (2021) New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments. International Journal of Molecular Sciences 22:19, pages 10498.
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Hugh S Taylor, Alexander M Kotlyar & Valerie A Flores. (2021) Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. The Lancet 397:10276, pages 839-852.
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Ryan M. Marquardt, Tae Hoon Kim, Jung-Ho Shin & Jae-Wook Jeong. (2019) Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?. International Journal of Molecular Sciences 20:15, pages 3822.
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Pedro Alvarez, Oliver Bogen & Jon D. Levine. (2014) Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain. Pain 155:12, pages 2680-2686.
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Sang Jun Han & Bert W. O'Malley. (2014) The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis. Human Reproduction Update 20:4, pages 467-484.
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Hanyia Naqvi, Sharif Sakr, Thomas Presti, Graciela Krikun, Barry Komm & Hugh S. Taylor. (2014) Treatment with Bazedoxifene and Conjugated Estrogens Results in Regression of Endometriosis in a Murine Model1. Biology of Reproduction 90:6.
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Sharif Sakr, Hanyia Naqvi, Barry Komm & Hugh S. Taylor. (2014) Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment. Endocrinology 155:4, pages 1489-1497.
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Sun-Wei Guo. (2014) An overview of the current status of clinical trials on endometriosis: issues and concerns. Fertility and Sterility 101:1, pages 183-190.e4.
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Manal A. Abbas, Mutasem O. Taha, Ahmad M. Disi & Maha Shomaf. (2013) Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis. European Journal of Pharmacology 715:1-3, pages 72-75.
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Sérgio Reis Soares, Alicia Martínez-Varea, Juan José Hidalgo-Mora & Antonio Pellicer. (2012) Pharmacologic therapies in endometriosis: a systematic review. Fertility and Sterility 98:3, pages 529-555.
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E. N. Burgova, L. V. Adamyan, N. A. Tkachev, A. A. Stepanyan & A. F. Vanin. (2012) Dinitrosyl iron complexes with cysteine suppress the development of experimental endometriosis in rats. Biophysics 57:1, pages 87-89.
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Moamar Al-Jefout. (2011) Brief update on endometriosis treatment. Middle East Fertility Society Journal 16:3, pages 167-174.
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Jaime KulakJrJrCatha FischerBarry Komm & Hugh S. Taylor. (2011) Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model. Endocrinology 152:8, pages 3226-3232.
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Yi-Jen Chen, Hsin-Yang Li, Chi-Hung Huang, Nae-Fang Twu, Ming-Shyen Yen, Peng-Hui Wang, Teh-Ying Chou, Yen-Ni Liu, Kuan-Chong Chao & Muh-Hwa Yang. (2010) Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis. The Journal of Pathology 222:3, pages 261-270.
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Devrim Altintas, Arif Kokcu, Bedri Kandemir, Migraci Tosun & Mehmet B. Cetinkaya. (2010) Comparison of the effects of raloxifene and anastrozole on experimental endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology 150:1, pages 84-87.
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Meredith T. Robbins, Hannah Mebane, Chelsea L. Ball, Amber D. Shaffer & Timothy J. Ness. (2010) Effect of Estrogen on Bladder Nociception in Rats. The Journal of Urology 183:3, pages 1201-1205.
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Vera Lúcia Rodrigues Lobo, José Maria Soares Júnior, Manuel de Jesus Simões, Ricardo dos Santos Simões, Geraldo Rodrigues de Lima & Edmund C Baracat. (2008) Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?. Clinics 63:4, pages 525-530.
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Xishi Liu & Sun-Wei Guo. (2008) A pilot study on the off-label use of valproic acid to treat adenomyosis. Fertility and Sterility 89:1, pages 246-250.
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Ruth Grümmer. (2006) Animal models in endometriosis research. Human Reproduction Update 12:5, pages 641-649.
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Yan Wu & Sun-Wei Guo. (2006) Inhibition of Proliferation of Endometrial Stromal Cells by Trichostatin A, RU486, CDB-2914, N-Acetylcysteine, and ICI 182780. Gynecologic and Obstetric Investigation 62:4, pages 193-205.
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