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INVITED REVIEW

The Role of Complement, C5a and Its Receptors in Sepsis and Multiorgan Dysfunction Syndrome

, MD, , MD & , MD
Pages 255-265 | Received 22 Mar 2006, Accepted 27 Mar 2006, Published online: 09 Jul 2009

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Xiao-Yu Qing, Chun-Hui Zhang, Lin-Li Li, Pan Ji, Shuang Ma, Hua-Lin Wan, Ze-Rong Wang, Jun Zou & Sheng-Yong Yang. (2013) Retrieving novel C5aR antagonists using a hybrid ligand-based virtual screening protocol based on SVM classification and pharmacophore models. Journal of Biomolecular Structure and Dynamics 31:2, pages 215-223.
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V. Kumar & A. Sharma. (2008) Innate Immunity in Sepsis Pathogenesis and Its Modulation: New Immunomodulatory Targets Revealed. Journal of Chemotherapy 20:6, pages 672-683.
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Sae Jin Oh, Ji Hyung Kim & Doo Hyun Chung. (2013) NOD2-mediated Suppression of CD55 on Neutrophils Enhances C5a Generation During Polymicrobial Sepsis. PLoS Pathogens 9:5, pages e1003351.
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Miriam D Neher, Sebastian Weckbach, Michael A Flierl, Markus S Huber-Lang & Philip F Stahel. (2011) Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"?. Journal of Biomedical Science 18:1.
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Dennis E. Hourcade & Lynne M. Mitchell. (2011) Access to the Complement Factor B Scissile Bond Is Facilitated by Association of Factor B with C3b Protein. Journal of Biological Chemistry 286:41, pages 35725-35732.
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Timothy T. CornellJames Wynn, Thomas P. ShanleyDerek S. Wheeler & Hector R. Wong. (2010) Mechanisms and Regulation of the Gene-Expression Response to Sepsis. Pediatrics 125:6, pages 1248-1258.
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William R. Parrish, Margot Gallowitsch-Puerta, Christopher J. Czura & Kevin J. Tracey. (2008) Experimental Therapeutic Strategies for Severe Sepsis. Annals of the New York Academy of Sciences 1144:1, pages 210-236.
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Karlee L. Silver, Kevin C. Kain & W. Conrad Liles. (2007) Endothelial activation and dysregulation: A common pathway to organ injury in infectious diseases associated with systemic inflammation. Drug Discovery Today: Disease Mechanisms 4:4, pages 215-222.
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