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Journal of Investigative Surgery Volume 31, 2018 - Issue 6
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Original Research

Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury

Alexandra K. TsarouchaPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, GreeceCorrespondence[email protected] [email protected] [email protected]
, MD, PhD,
Georgia ValsamiSchool of Health Sciences, Department of Pharmacy, National and Kapodistrian University of Athens, Greece
, PhD,
Nikolaos KostomitsopoulosDepartment of Experimental Surgery, Bioresearch Foundation of the Academy of Athens, Athens, Greece
, DVM, PhD,
Maria LambropoulouLaboratory of Histology-Embryology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
, MD, PhD,
Constantinos AnagnostopoulosLaboratory of Biochemistry, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
, PhD,
Eirini ChristodoulouSchool of Health Sciences, Department of Pharmacy, National and Kapodistrian University of Athens, Greece
, MSc,
Evangelos FalidasPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
, MD, MSc,
Afrodite BetsouPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
, MD, MSc,
Michael PitiakoudisPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
, MD, PhD &
Constantinos E. SimopoulosPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;2nd Department of Surgery and Laboratory of Experimental Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Department of Experimental Surgery, Bioresearch Foundation of the Academy of Athens, Athens, Greece
, MD, PhD show all
Pages 491-502 | Received 05 Jun 2017, Accepted 24 Jul 2017, Published online: 27 Sep 2017

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John Mackay Søfteland & Mihai Oltean. (2021) Intestinal Ischemia-Reperfusion Injury and Calcium Channel Blockers: Getting to the Core of the Problem. Journal of Investigative Surgery 34:7, pages 808-809.
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Articles from other publishers (17)

Reinhart Speeckaert, Vedrana Bulat, Marijn M. Speeckaert & Nanja van Geel. (2023) The Impact of Antioxidants on Vitiligo and Melasma: A Scoping Review and Meta-Analysis. Antioxidants 12:12, pages 2082.
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Nikolaos P. E. Kadoglou, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Nikolaos G. Kostomitsopoulos, Alexandra K. Tsaroucha & Georgia Valsami. (2022) A Comprehensive Review of the Cardiovascular Protective Properties of Silibinin/Silymarin: A New Kid on the Block. Pharmaceuticals 15:5, pages 538.
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Georgios Kyriakopoulos, Maria Lambropoulou, Georgia Valsami, Nikolaos Kostomitsopoulos, Ourania Konstandi, Konstantinos Anagnostopoulos, Christos Tsalikidis, Panagoula Oikonomou, Konstantinos Simopoulos & Alexandra K. Tsaroucha. (2022) Pro‐inflammatory cytokines/chemokines, TNF‐α, IL‐6 and MCP‐1, as biomarkers for the nephro‐ and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: Confirmation by immunohistochemistry and qRT‐PCR. Basic & Clinical Pharmacology & Toxicology 130:4, pages 457-467.
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Hao Wang, Jiali Zhu, Zhe Jia & Sucai Lu. (2022) Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1 and silibinin protects liver from ischemia-reperfusion injury through an AMPK-dependent mechanism. Turkish Journal of Biochemistry 47:1, pages 23-32.
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Cong Chen, Lin-Tong Yu, Bai-Ru Cheng, Jiang-Lin Xu, Yun Cai, Jia-Lin Jin, Ru-Li Feng, Long Xie, Xin-Yan Qu, Dong Li, Jing Liu, Yan Li, Xiao-Yun Cui, Jin-Jin Lu, Kun Zhou, Qian Lin & Jie Wan. (2022) Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?. Frontiers in Cardiovascular Medicine 8.
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Afrodite Betsou, Maria Lambropoulou, Anastasia-Eirini Georgakopoulou, Nikolaos Kostomitsopoulos, Ourania Konstandi, Konstantinos Anagnostopoulos, Christos Tsalikidis, Constantinos E Simopoulos, Georgia Valsami & Alexandra K Tsaroucha. (2021) The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR. Journal of Pharmacy and Pharmacology 73:9, pages 1274-1284.
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Václav Tvrdý, Jana Pourová, Eduard Jirkovský, Vladimír Křen, Kateřina Valentová & Přemysl Mladěnka. (2021) Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin. Medicinal Research Reviews 41:4, pages 2195-2246.
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Vasileios Kollaras, Georgia Valsami, Maria Lambropoulou, Ourania Konstandi, Nikolaos Kostomistsopoulos, Emmanouil Pikoulis, Constantinos Simopoulos & Alexandra Tsaroucha. (2021) Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury in an experimental rat model. Acta Cirúrgica Brasileira 36:9.
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Eirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis, Thomas Mavromoustakos & Georgia Valsami. 2021. Supramolecules in Drug Discovery and Drug Delivery. Supramolecules in Drug Discovery and Drug Delivery 1 11 .
Georgios Kyriakopoulos, Georgia Valsami, Christos Tsalikidis, Michail Pitiakoudis & Alexandra K. Tsaroucha. (2020) Use of natural anti-oxidants in experimental animal models of hepatic ischemia-reperfusion injury. Annals of Medicine and Surgery 60, pages 592-599.
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Alexandra K. Tsaroucha, Georgios N. Korovesis, Georgia Valsami, Maria Lambropoulou, Vasileios Kollaras, Constatinos Anagnostopoulos, Nikolaos Kostomitsopoulos, Eleni Zerbini & Constantinos Simopoulos. (2020) Silibinin-hydroxypropyl-β-cyclodextrin (SLB-HP-β-CD) complex prevents apoptosis in liver and kidney after hepatic ischemia-reperfusion injury. Food and Chemical Toxicology 145, pages 111731.
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Ahmed M. Sayed, Emad H.M. Hassanein, Shimaa H. Salem, Omnia E. Hussein & Ayman M. Mahmoud. (2020) Flavonoids-mediated SIRT1 signaling activation in hepatic disorders. Life Sciences 259, pages 118173.
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Ruochen CongJushun YangJie ZhouJianhua ShiYihua ZhuJianfeng ZhuJing XiaoPing WangYing HeBosheng He. (2020) The Potential Role of Protein Tyrosine Phosphatase, Receptor Type C (CD45) in the Intestinal Ischemia–Reperfusion Injury. Journal of Computational Biology 27:8, pages 1303-1312.
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Yuan Xu, Yulin Niu, Haiyang Li & Guanghui Pan. (2020) Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation 43:4, pages 1362-1374.
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Haibo Zou & Xiaofeng Sun. (2020) Effects of cyclosporin A pre-treatment combined with etomidate post-treatment on lung injury induced by limb ischemia-reperfusion in rats. Journal of International Medical Research 48:7, pages 030006052093462.
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Yong Zhang, Jianrui Lv, Gang Wu, Wei Li, Zhenni Zhang, Weisong Li & Xiaoming Lei. (2019) MicroRNA‐449b‐5p targets HMGB1 to attenuate hepatocyte injury in liver ischemia and reperfusion. Journal of Cellular Physiology 234:9, pages 16367-16375.
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Weiqiang Chen, Li He, Hui Jin, John D’Angelo, Guoqiang Bao & Haichao Wang. 2019. Severe Trauma and Sepsis. Severe Trauma and Sepsis 229 252 .

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