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Inhalation Toxicology
International Forum for Respiratory Research
Volume 12, 2000 - Issue 12
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Research Article

CYCLOOXYGENASE METABOLITES PLAY A DIFFERENT ROLE IN OZONE-INDUCED PULMONARY FUNCTION DECLINE IN ASTHMATICS COMPARED TO NORMALS

Neil Alexis, Bruce Urch, Susan Tarlo, Paul Corey, David Pengelly, Paul O'Byrne, Frances Silverman Gage Occupational and Environmental Health Unit, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Pages 1205-1224 | Published online: 01 Oct 2008

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Robyn L. Prueitt & Julie E. Goodman. (2016) Evaluation of neural reflex activation as a mode of action for the acute respiratory effects of ozone. Inhalation Toxicology 28:11, pages 484-499.
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Stephanie A. Shore, Erin S. Williams, Lucas Chen, Leandro A.P. Benedito, David I. Kasahara & Ming Zhu. (2011) Impact of aging on pulmonary responses to acute ozone exposure in mice: role of TNFR1. Inhalation Toxicology 23:14, pages 878-888.
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N. Stenfors, J. Bosson, R. Helleday, A. F. Behndig, J. Pourazar, H. Törnqvist, F. J. Kelly, A. J. Frew, T. Sandström, I. S. Mudway & A. Blomberg. (2010) Ozone exposure enhances mast-cell inflammation in asthmatic airways despite inhaled corticosteroid therapy. Inhalation Toxicology 22:2, pages 133-139.
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Articles from other publishers (31)

Kelly M. Bakulski, Freida Blostein & Stephanie J. London. (2023) Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations. Environmental Health Perspectives 131:12.
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Valérie Bougault, Paolo Emilio Adami, Nicola Sewry, Ken Fitch, Christopher Carlsten, Beat Villiger, Martin Schwellnus & Wolfgang Schobersberger. (2022) Environmental factors associated with non-infective acute respiratory illness in athletes: A systematic review by a subgroup of the IOC consensus group on “acute respiratory illness in the athlete”. Journal of Science and Medicine in Sport 25:6, pages 466-473.
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Christina M. Eckhardt & Haotian Wu. (2021) Environmental Exposures and Lung Aging: Molecular Mechanisms and Implications for Improving Respiratory Health. Current Environmental Health Reports 8:4, pages 281-293.
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Ross S. Osgood, Hiroki Tashiro, David I. Kasahara, Vladimir Yeliseyev, Lynn Bry & Stephanie A. Shore. (2020) Gut microbiota from androgen‐altered donors alter pulmonary responses to ozone in female mice. Physiological Reports 8:19.
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Samantha C Faber, Nicole A McNabb, Pablo Ariel, Emily R Aungst & Shaun D McCullough. (2020) Exposure Effects Beyond the Epithelial Barrier: Transepithelial Induction of Oxidative Stress by Diesel Exhaust Particulates in Lung Fibroblasts in an Organotypic Human Airway Model. Toxicological Sciences 177:1, pages 140-155.
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Xu Gao & Andrea Baccarelli. (2020) Reply to Alexis: Controlled Chamber Studies Showed Protective Effect of Nonsteroidal Antiinflammatory Drugs against Ozone Exposure: The Stage Was Set for Broader Epidemiologic Investigation. American Journal of Respiratory and Critical Care Medicine 201:12, pages 1583-1584.
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Neil E. Alexis. (2020) Controlled Chamber Studies Showed Protective Effect of Nonsteroidal Antiinflammatory Drugs against Ozone Exposure: The Stage Was Set for Broader Epidemiologic Investigation. American Journal of Respiratory and Critical Care Medicine 201:12, pages 1583-1583.
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Morton Lippmann. 2020. Environmental Toxicants. Environmental Toxicants 783 853 .
Ross S. Osgood, David I. Kasahara, Hiroki Tashiro, Youngji Cho & Stephanie A. Shore. (2019) Androgens augment pulmonary responses to ozone in mice. Physiological Reports 7:18.
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Paris Lee & Lynn M. Ulatowski. (2018) Vitamin E: Mechanism of transport and regulation in the CNS. IUBMB Life 71:4, pages 424-429.
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Youngji Cho, Galeb Abu-Ali, Hiroki Tashiro, David I. Kasahara, Traci A. Brown, Jeffrey D. Brand, Joel A. Mathews, Curtis Huttenhower & Stephanie A. Shore. (2018) The Microbiome Regulates Pulmonary Responses to Ozone in Mice. American Journal of Respiratory Cell and Molecular Biology 59:3, pages 346-354.
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Kenneth W. Rundell, James M. Smoliga & Valérie Bougault. (2018) Exercise-Induced Bronchoconstriction and the Air We Breathe. Immunology and Allergy Clinics of North America 38:2, pages 183-204.
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Sumit Sharma. 2016. Economic Modeling, Analysis, and Policy for Sustainability. Economic Modeling, Analysis, and Policy for Sustainability 284 306 .
David B. Peden. 2015. Air Pollution and Health Effects. Air Pollution and Health Effects 93 117 .
Lisa C. Vinikoor-Imler, Elizabeth O. Owens, Jennifer L. Nichols, Mary Ross, James S. Brown & Jason D. Sacks. (2014) Evaluating Potential Response-Modifying Factors for Associations between Ozone and Health Outcomes: A Weight-of-Evidence Approach. Environmental Health Perspectives 122:11, pages 1166-1176.
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Rebecca C. FryJulia E. RagerRebecca BauerElizabeth SebastianDavid B. Peden, Ilona Jaspers & Neil E. Alexis. (2014) Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects. American Journal of Physiology-Lung Cellular and Molecular Physiology 306:12, pages L1129-L1137.
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Julie E. Goodman, Robyn L. Prueitt, Juhi Chandalia & Sonja N. Sax. (2014) Evaluation of adverse human lung function effects in controlled ozone exposure studies. Journal of Applied Toxicology 34:5, pages 516-524.
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Michelle L. Hernandez & David B. Peden. 2014. Middleton's Allergy. Middleton's Allergy 482 496 .
Alison Suzanne Williams, Joel Andrew Mathews, David Itiro Kasahara, Lucas Chen, Allison Patricia Wurmbrand, Huiqing Si & Stephanie Ann Shore. (2013) Augmented Pulmonary Responses to Acute Ozone Exposure in Obese Mice: Roles of TNFR2 and IL-13. Environmental Health Perspectives 121:5, pages 551-557.
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Amy Auerbach & Michelle L. Hernandez. (2012) The effect of environmental oxidative stress on airway inflammation. Current Opinion in Allergy & Clinical Immunology 12:2, pages 133-139.
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Amir Y Tashakkor, Katherine S Chow & Chris Carlsten. (2011) Modification by antioxidant supplementation of changes in human lung function associated with air pollutant exposure: A systematic review. BMC Public Health 11:1.
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David B. Peden. (2011) The role of oxidative stress and innate immunity in O3 and endotoxin-induced human allergic airway disease. Immunological Reviews 242:1, pages 91-105.
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Michelle L. Hernandez, John C. Lay, Bradford Harris, Charles R. EstherJr.Jr., W. June Brickey, Philip A. Bromberg, David Diaz-Sanchez, Robert B. Devlin, Steven R. Kleeberger, Neil E. Alexis & David B. Peden. (2010) Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone. Journal of Allergy and Clinical Immunology 126:3, pages 537-544.e1.
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David Peden & Charles E. Reed. (2010) Environmental and occupational allergies. Journal of Allergy and Clinical Immunology 125:2, pages S150-S160.
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Morton Lippmann. 2009. Environmental Toxicants. Environmental Toxicants 869 936 .
David B. Peden. 2009. Middleton's Allergy: Principles and Practice. Middleton's Allergy: Principles and Practice 495 508 .
Neil E. Alexis, John C. Lay, Angela Haczku, Henry Gong, William Linn, Milan J. Hazucha, Brad Harris, Ruth Tal-Singer & David B. Peden. (2008) Fluticasone Propionate Protects against Ozone-Induced Airway Inflammation and Modified Immune Cell Activation Markers in Healthy Volunteers. Environmental Health Perspectives 116:6, pages 799-805.
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Richard A. Johnston, Joseph P. Mizgerd & Stephanie A. Shore. (2005) CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure. American Journal of Physiology-Lung Cellular and Molecular Physiology 288:1, pages L61-L67.
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Debra Laskin, Carol Gardner, Donald Gerecke & Jeffrey Laskin. 2004. Oxygen/Nitrogen Radicals. Oxygen/Nitrogen Radicals 289 316 .
Neil E Alexis, Suzanne Becker, Philip A Bromberg, Robert Devlin & David B Peden. (2004) Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans. Clinical Immunology 111:1, pages 126-131.
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NEIL E. ALEXIS, SHU-CHIEH HU, KIRBY ZEMAN, TODD ALTER & WILLIAM D. BENNETT. (2001) Induced Sputum Derives from the Central Airways. American Journal of Respiratory and Critical Care Medicine 164:10, pages 1964-1970.
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