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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 3
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Research Article

SHORT-TERM INHALATION TOXICITY OF POLYISOCYANATE AEROSOLS IN RATS: COMPARATIVE ASSESSMENT OF IRRITANT-THRESHOLD CONCENTRATIONS BY BRONCHOALVEOLAR LAVAGE

Pages 287-301 | Published online: 01 Oct 2008

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J. Pauluhn, A. Carson, D. L. Costa, T. Gordon, U. Kodavanti, J. A. Last, M. A. Matthay, K. E. Pinkerton & A. M. Sciuto. (2007) Workshop Summary: Phosgene-Induced Pulmonary Toxicity Revisited: Appraisal of Early and Late Markers of Pulmonary Injury From Animal Models With Emphasis on Human Significance. Inhalation Toxicology 19:10, pages 789-810.
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Articles from other publishers (26)

Marcia English, Ogadimma Desmond Okagu, Kristen Stephens, Alex Goertzen & Chibuike C. Udenigwe. (2023) Flavour encapsulation: A comparative analysis of relevant techniques, physiochemical characterisation, stability, and food applications. Frontiers in Nutrition 10.
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Said El Khezraji, Hicham Ben youcef, Larbi Belachemi, Miguel A. Lopez Manchado, Raquel Verdejo & Mohammed Lahcini. (2023) Recent Progress of Non-Isocyanate Polyurethane Foam and Their Challenges. Polymers 15:2, pages 254.
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Xue Wang, Anna-Christina Amason, Yabin Lei, Ron Gabbard, Julie Ann Wieland & Richard A. Gross. (2022) Bio-based alternative for encapsulating fragrance oils in epoxy resin microcapsules. Colloids and Surfaces A: Physicochemical and Engineering Aspects 640, pages 128387.
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Elena Mazzon, Pascal Guigues & Jean-Pierre Habas. (2020) Biobased structural epoxy foams derived from plant-oil: Formulation, manufacturing and characterization. Industrial Crops and Products 144, pages 111994.
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Chen-Chung Lin, Brandon F Law & Justin M Hettick. (2019) Acute 4,4′-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages. Toxicological Sciences.
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Colin M. North, Janine Ezendam, Jon A. Hotchkiss, Curtis Maier, Kohji Aoyama, Steve Enoch, Amber Goetz, Cynthia Graham, Ian Kimber, Antti Karjalainen, Juergen Pauluhn, Erwin L. Roggen, MaryJane Selgrade, Susan M. Tarlo & Connie L. Chen. (2016) Developing a framework for assessing chemical respiratory sensitization: A workshop report. Regulatory Toxicology and Pharmacology 80, pages 295-309.
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. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 58 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 52 .
Juergen Pauluhn. 2014. Inhalation Toxicology, Third Edition. Inhalation Toxicology, Third Edition 121 136 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 45 .
Jürgen Pauluhn. (2011) Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology. Regulatory Toxicology and Pharmacology 61:3, pages 351-364.
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Jürgen Pauluhn & Alan Poole. (2011) Brown Norway rat asthma model of diphenylmethane-4,4′-diisocyanate (MDI): Determination of the elicitation threshold concentration of after inhalation sensitization. Toxicology 281:1-3, pages 15-24.
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Jürgen Pauluhn. (2009) Pulmonary Toxicity and Fate of Agglomerated 10 and 40 nm Aluminum Oxyhydroxides following 4-Week Inhalation Exposure of Rats: Toxic Effects are Determined by Agglomerated, not Primary Particle Size. Toxicological Sciences 109:1, pages 152-167.
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Jürgen Pauluhn. (2008) Brown Norway Rat Asthma Model of Diphenylmethane-4,4′-Diisocyanate (MDI): Analysis of the Elicitation Dose-Response Relationship. Toxicological Sciences 104:2, pages 320-331.
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Jürgen Pauluhn. (2008) Inhalation toxicology: Methodological and regulatory challenges. Experimental and Toxicologic Pathology 60:2-3, pages 111-124.
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Jürgen Pauluhn. (2008) Comparative assessment of early acute lung injury in mice and rats exposed to 1,6-hexamethylene diisocyanate–polyisocyanate aerosols. Toxicology 247:1, pages 33-45.
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Jürgen Pauluhn. (2008) Brown Norway rat asthma model of diphenylmethane-4,4′-diisocyanate (MDI): Impact of vehicle for topical induction. Regulatory Toxicology and Pharmacology 50:1, pages 144-154.
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L. Ma-Hock, A.O. Gamer, K. Deckardt, E. Leibold & B. van Ravenzwaay. (2007) Determination of pulmonary irritant threshold concentrations of hexamethylene-1,6-diisocyanate (HDI) prepolymers by bronchoalveolar lavage in acute rat inhalation studies according to TRGS 430. Food and Chemical Toxicology 45:2, pages 237-243.
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Jürgen Pauluhn, William E. Brown, Paul Hext, Edgar Leibold & Gabriele Leng. (2006) Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct. Toxicology 222:3, pages 202-212.
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Jürgen Pauluhn & Ulrich Mohr. (2006) Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose-only inhalation study in rats. Journal of Applied Toxicology 26:3, pages 279-292.
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Jürgen Pauluhn & Ulrich Mohr. (2005) Experimental approaches to evaluate respiratory allergy in animal models. Experimental and Toxicologic Pathology 56:4-5, pages 203-234.
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Jürgen Pauluhn. (2005) Inhaled cationic amphiphilic drug-induced pulmonary phospholipidosis in rats and dogs: time-course and dose–response of biomarkers of exposure and effect. Toxicology 207:1, pages 59-72.
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Dhimiter Bello, Susan R. Woskie, Robert P. Streicher, Youcheng Liu, Meredith H. Stowe, Ellen A. Eisen, Michael J. Ellenbecker, Judy Sparer, Fred Youngs, Mark R. Cullen & Carrie A. Redlich. (2004) Polyisocyanates in occupational environments: A critical review of exposure limits and metrics. American Journal of Industrial Medicine 46:5, pages 480-491.
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Jürgen Pauluhn. (2004) Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage. Journal of Applied Toxicology 24:3, pages 247-17.
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Juergen Pauluhn. 2003. Encyclopedia of Agrochemicals. Encyclopedia of Agrochemicals.

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