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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 4
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Research Article

TIME COURSE OF PULMONARY RESPONSE OF RATS TO INHALATION OF CRYSTALLINE SILICA: NF-kappa B ACTIVATION, INFLAMMATION, CYTOKINE PRODUCTION, AND DAMAGE

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Pages 349-367 | Published online: 01 Oct 2008

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John Wong, Bruce E Magun & Lisa J Wood. (2016) Lung inflammation caused by inhaled toxicants: a review. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 1391-1401.
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Hajime Kawasaki. (2015) A mechanistic review of silica-induced inhalation toxicity. Inhalation Toxicology 27:8, pages 363-377.
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Brooke T. Mossman & Robert E. Glenn. (2013) Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs). Critical Reviews in Toxicology 43:8, pages 632-660.
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Rajendran Sellamuthu, Christina Umbright, Shengqiao Li, Michael Kashon & Pius Joseph. (2011) Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. Inhalation Toxicology 23:14, pages 927-937.
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Raymond J. Langley, Neerad C. Mishra, Juan Carlos Peña-Philippides, Brandon J. Rice, Jean-Clare Seagrave, Shashi P. Singh & Mohan L. Sopori. (2011) Fibrogenic and Redox-Related but not Proinflammatory Genes are Upregulated in Lewis Rat Model of Chronic Silicosis. Journal of Toxicology and Environmental Health, Part A 74:19, pages 1261-1279.
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Iraj Mohebbi, Isa Abdi Rad & Morteza Bagheri. (2010) Association of angiotensin-1-converting enzyme gene variations with silicosis predisposition. Inhalation Toxicology 22:13, pages 1110-1115.
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M. Gulumian, P. J. A. Borm, V. Vallyathan, V. Castranova, K. Donaldson, G. Nelson & J. Murray. (2006) Mechanistically Identified Suitable Biomarkers of Exposure, Effect, and Susceptibility for Silicosis and Coal-Worker'S Pneumoconiosis: A Comprehensive Review. Journal of Toxicology and Environmental Health, Part B 9:5, pages 357-395.
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K. Murali Krishna Rao & Terence Meighan. (2006) Exposure In Vivo to Silica or Lipopolysaccharide Produces Transient or Sustained Upregulation, Respectively, of PYPAF7 and MEFV Genes in Bronchoalveolar Lavage Cells in Rats. Journal of Toxicology and Environmental Health, Part A 69:6, pages 481-490.
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Chung-Min Liao, Bo-Chun Wu, Yi-Hsien Cheng, Shu-Han You, Yi-Jun Lin & Nan-Hung Hsieh. (2015) Ceramics manufacturing contributes to ambient silica air pollution and burden of lung disease. Environmental Science and Pollution Research 22:19, pages 15067-15079.
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Jana Keller, Wendel Wohlleben, Lan Ma-Hock, Volker Strauss, Sibylle Gröters, Karin Küttler, Karin Wiench, Christiane Herden, Günter Oberdörster, Bennard van Ravenzwaay & Robert Landsiedel. (2014) Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria. Archives of Toxicology 88:11, pages 2033-2059.
Crossref
Pius Joseph, Christina Umbright & Rajendran Sellamuthu. 2014. Inhalation Toxicology, Third Edition. Inhalation Toxicology, Third Edition 423 458 .
Celine A. Beamer & David M. Shepherd. (2013) Role of the aryl hydrocarbon receptor (AhR) in lung inflammation. Seminars in Immunopathology 35:6, pages 693-704.
Crossref
Pius Joseph, Christina Umbright & Rajendran Sellamuthu. (2013) Blood transcriptomics: applications in toxicology. Journal of Applied Toxicology 33:11, pages 1193-1202.
Crossref
Wei Chung Liu, Chang Shu Tsai, Ya Yun Chen & Nien Tzu Keng. (2013) Erythropoietin Gene Expression in the Stromal Cell Increased by Silica to Induce Erythrocyte Differentiation. Advanced Materials Research 647, pages 494-498.
Crossref
Celine A. Beamer, Benjamin P. Seaver & David M. Shepherd. (2012) Aryl Hydrocarbon Receptor (AhR) Regulates Silica-Induced Inflammation But Not Fibrosis. Toxicological Sciences 126:2, pages 554-568.
Crossref
Gayatri Premasekharan, Kennedy Nguyen, Janette Contreras, Virginia Ramon, Valerie Jean Leppert & Henry Jay Forman. (2011) Iron-mediated lipid peroxidation and lipid raft disruption in low-dose silica-induced macrophage cytokine production. Free Radical Biology and Medicine 51:6, pages 1184-1194.
Crossref
Rajendran Sellamuthu, Christina Umbright, Jenny R. Roberts, Rebecca Chapman, Shih-Houng Young, Diana Richardson, Howard Leonard, Walter McKinney, Bean Chen, David Frazer, Shengqiao Li, Michael Kashon & Pius Joseph. (2011) Blood Gene Expression Profiling Detects Silica Exposure and Toxicity. Toxicological Sciences 122:2, pages 253-264.
Crossref
Virginie Rabolli, Sandra Lo Re, Francine Uwambayinema, Yousof Yakoub, Dominique Lison & François Huaux. (2011) Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. Toxicology Letters 203:2, pages 127-134.
Crossref
K.E. Driscoll & G.D. Guthrie. 2010. Comprehensive Toxicology. Comprehensive Toxicology 331 350 .
Michelangelo Di Giuseppe, Federica Gambelli, Gary W. Hoyle, Giuseppe Lungarella, Sean M. Studer, Thomas Richards, Sam Yousem, Ken McCurry, James Dauber, Naftali Kaminski, George Leikauf & Luis A. Ortiz. (2009) Systemic Inhibition of NF-κB Activation Protects from Silicosis. PLoS ONE 4:5, pages e5689.
Crossref
D van Berlo, C Albrecht, A M Knaapen, F J van Schooten & R P F Schins. (2009) The role of macrophage mediators in respirable quartz-elicited inflammation. Journal of Physics: Conference Series 151, pages 012046.
Crossref
Andrew Churg, Manuel Cosio & Joanne L. Wright. (2008) Mechanisms of cigarette smoke-induced COPD: insights from animal models. American Journal of Physiology-Lung Cellular and Molecular Physiology 294:4, pages L612-L631.
Crossref
Honglei Liu, Hongqiao Zhang & Henry Jay Forman. (2007) Silica Induces Macrophage Cytokines through Phosphatidylcholine-Specific Phospholipase C with Hydrogen Peroxide. American Journal of Respiratory Cell and Molecular Biology 36:5, pages 594-599.
Crossref
Debra L. Laskin, Vasanthi R. Sunil, Robert J. Laumbach & Howard M. Kipen. 2007. Cytokines in Human Health. Cytokines in Human Health 83 112 .
Stephen Leonard, Dale Porter & Vincent Castranova. 2006. Particle Toxicology. Particle Toxicology 119 138 .
Dale W. Porter, Lyndell L. Millecchia, Patsy Willard, Victor A. Robinson, Dawn Ramsey, Jeffery McLaurin, Amir Khan, Kurt Brumbaugh, Christoper M. Beighley, Alexander Teass & Vincent Castranova. (2006) Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation. Toxicological Sciences 90:1, pages 188-197.
Crossref
Gilles Lalmanach, Elisabeth Diot, Emmanuel Godat, Fabien Lecaille & Virginie Hervé-Grépinet. (2006) Cysteine cathepsins and caspases in silicosis. Biological Chemistry 387:7.
Crossref
Mohammed S. RazzaqueAndrea K. Hubbard, Sarah Mowbray, Michael Thibodeau & Charles Giardina. 2005. Fibrogenesis: Cellular and Molecular Basis. Fibrogenesis: Cellular and Molecular Basis 199 210 .
K. Murali Krishna Rao, Dale W. Porter, Terence Meighan & Vince Castranova. (2004) The Sources of Inflammatory Mediators in the Lung after Silica Exposure. Environmental Health Perspectives 112:17, pages 1679-1685.
Crossref
Fei Chen & Val Vallyathan. 2004. Phytopharmaceuticals in Cancer Chemoprevention. Phytopharmaceuticals in Cancer Chemoprevention.
Vincent Castranova. (2004) Signaling Pathways Controlling The Production Of Inflammatory Mediators in Response To Crystalline Silica Exposure: Role Of Reactive Oxygen/Nitrogen Species. Free Radical Biology and Medicine 37:7, pages 916-925.
Crossref
Catrin Albrecht, Roel P. F. Schins, Doris Höhr, Andrea Becker, Tingming Shi, Ad M. Knaapen & Paul J. A. Borm. (2004) Inflammatory Time Course after Quartz Instillation. American Journal of Respiratory Cell and Molecular Biology 31:3, pages 292-301.
Crossref
Catrin Albrecht, Paul J.A Borm & Klaus Unfried. (2004) Signal transduction pathways relevant for neoplastic effects of fibrous and non-fibrous particles. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 553:1-2, pages 23-35.
Crossref
Raymond J. Langley, Roma Kalra, Neerad C. Mishra, Fletcher F. Hahn, Seddigheh Razani-Boroujerdi, Shashi P. Singh, Janet M. Benson, Juan Carlos Peña-Philippides, Edward B. Barr & Mohan L. Sopori. (2004) A Biphasic Response to Silica. American Journal of Respiratory Cell and Molecular Biology 30:6, pages 823-829.
Crossref
. 2004. Oxygen/Nitrogen Radicals. Oxygen/Nitrogen Radicals 161 177 .
E. D. Kuempel, M. D. Attfield, V. Vallyathan, N. L. Lapp, J. M. Hale, R. J. Smith & V. Castranova. (2003) Pulmonary inflammation and crystalline silica in respirable coal mine dust: Dose response. Journal of Biosciences 28:1, pages 61-69.
Crossref
Dale W. Porter, Lyndell Millecchia, Victor A. Robinson, Ann Hubbs, Patsy Willard, Donna Pack, Dawn Ramsey, Jeff McLaurin, Amir Khan, Douglas Landsittel, Alexander Teass & Vincent Castranova. (2002) Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica. American Journal of Physiology-Lung Cellular and Molecular Physiology 283:2, pages L485-L493.
Crossref
Dale W. Porter, Mark Barger, Victor A. Robinson, Stephen S. Leonard, Douglas Landsittel & Vincent Castranova. (2002) Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the rat. Toxicology 175:1-3, pages 63-71.
Crossref
Vincent Castranova, Dale Porter, Lyndell Millecchia, Jane Y. C. Ma, Ann F. Hubbs & Alexander Teass. 2002. Oxygen/Nitrogen Radicals: Cell Injury and Disease. Oxygen/Nitrogen Radicals: Cell Injury and Disease 177 184 .

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