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Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 10
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Research Article

Characterization of the Pharmacokinetics of Gasoline Using PBPK Modeling with a Complex Mixtures Chemical Lumping Approach

James E. Dennison Quantitative and Computational Toxicology Group, Center for Environmental Toxicology and Technology, Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, Colorado, USA
,
Melvin E. Andersen Quantitative and Computational Toxicology Group, Center for Environmental Toxicology and Technology, Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, Colorado, USA
&
Raymond S. H. Yang Quantitative and Computational Toxicology Group, Center for Environmental Toxicology and Technology, Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, Colorado, USA
Pages 961-986 | Published online: 01 Oct 2008

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Sheppard A. Martin, Wendy M. Oshiro, Paul A. Evansky, Laura L. Degn, Allen D. Ledbetter, Jermaine Ford, Q. Todd Krantz, William R. LeFew, Tracey E. Beasley, Hisham El-Masri, Eva D. McLanahan, William K. Boyes & Philip J. Bushnell. (2014) Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats. Inhalation Toxicology 26:10, pages 598-619.
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William LeFew & Hisham El-Masri. (2012) Computational estimation of errors generated by lumping of physiologically-based pharmacokinetic (PBPK) interaction models of inhaled complex chemical mixtures. Inhalation Toxicology 24:1, pages 36-46.
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Sheppard A. Martin, Jerry L. Campbell$suffix/text()$suffix/text(), Raphael T. Tremblay & Jeffrey W. Fisher. (2012) Development of a physiologically based pharmacokinetic model for inhalation of jet fuels in the rat. Inhalation Toxicology 24:1, pages 1-26.
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K. Price & K. Krishnan. (2011) An integrated QSAR–PBPK modelling approach for predicting the inhalation toxicokinetics of mixtures of volatile organic chemicals in the rat. SAR and QSAR in Environmental Research 22:1-2, pages 107-128.
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G. Joshi, R. T. Tremblay, S. A. Martin & J. W. Fisher. (2010) Partition coefficients for nonane and its isomers in the rat. Toxicology Mechanisms and Methods 20:9, pages 594-599.
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Ivan D. Dobrev, Andy Nong, Kai H. Liao, Micaela B. Reddy, Kathleen P. Plotzke & Melvin E. Andersen. (2008) Assessing Kinetic Determinants for Metabolism and Oral Uptake of Octamethylcyclotetrasiloxane (D) from Inhalation Chamber Studies. Inhalation Toxicology 20:4, pages 361-373.
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Ivan Nestorov. (2007) Whole-body physiologically based pharmacokinetic models. Expert Opinion on Drug Metabolism & Toxicology 3:2, pages 235-249.
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Jerry L. Campbell$suffix/text()$suffix/text() & Jeffrey W. Fisher. (2007) A PBPK Modeling Assessment of the Competitive Metabolic Interactions of JP-8 Vapor with Two Constituents, m-Xylene and Ethylbenzene. Inhalation Toxicology 19:3, pages 265-273.
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James E. Dennison, Melvin E. Andersen & Raymond S.H. Yang. (2005) Pitfalls and Related Improvements of In Vivo Gas Uptake Pharmacokinetic Experimental Systems. Inhalation Toxicology 17:11, pages 539-548.
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Johannes G. Filser, Winfried Kessler & György A. Csanády. (2004) The “Tuebingen Desiccator” System, a Tool to Study Oxidative Stress In Vivo and Inhalation Toxicokinetics. Drug Metabolism Reviews 36:3-4, pages 787-803.
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U. R. Perleberg, D. A. Keys & J. W. Fisher. (2004) Development of a Physiologically Based Pharmacokinetic Model for Decane, a Constituent of Jet Propellent-8. Inhalation Toxicology 16:11-12, pages 771-783.
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Articles from other publishers (35)

Harvey Clewell, Jerry Campbell & Matthew Linakis. (2023) Recent applications of physiologically based pharmacokinetic modeling to assess the toxicity of mixtures: A review. Current Opinion in Toxicology 34, pages 100390.
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Teresa R. Sterner, Tammie R. Covington & David R. Mattie. (2023) Complex Mixtures: Array PBPK Modeling of Jet Fuel Components. Toxics 11:2, pages 187.
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Jordan N. Smith, Kari A. Gaither & Paritosh Pande. (2022) Competitive Metabolism of Polycyclic Aromatic Hydrocarbons (PAHs): An Assessment Using In Vitro Metabolism and Physiologically Based Pharmacokinetic (PBPK) Modeling. International Journal of Environmental Research and Public Health 19:14, pages 8266.
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Lisa M. Sweeney & Teresa R. Sterner. (2022) Prediction of mammalian maximal rates of metabolism and Michaelis constants for industrial and environmental compounds: Revisiting four quantitative structure activity relationship (QSAR) publications. Computational Toxicology 21, pages 100214.
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C. J. Borgert, C. Fuentes & L. D. Burgoon. (2021) Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety. Archives of Toxicology 95:12, pages 3651-3664.
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Jeffrey W. Fisher, Jerry L. CampbellJr.Jr. & Zhoumeng Lin. 2020. Physiologically Based Pharmacokinetic (PBPK) Modeling. Physiologically Based Pharmacokinetic (PBPK) Modeling 161 173 .
Anteneh Desalegn, Stephanie Bopp, David Asturiol, Lara Lamon, Andrew Worth & Alicia Paini. (2019) Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures – A review. Computational Toxicology 10, pages 158-168.
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Sami Haddad. 2018. Chemical Mixtures and Combined Chemical and Nonchemical Stressors. Chemical Mixtures and Combined Chemical and Nonchemical Stressors 307 333 .
Micah N. Jasper, Sheppard A. Martin, Wendy M. Oshiro, Jermaine Ford, Philip J. Bushnell & Hisham El-Masri. (2016) Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture. Environmental Science & Technology 50:6, pages 3231-3238.
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. (2014) Modern methodologies and tools for human hazard assessment of chemicals. EFSA Journal 12:4.
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. (2013) International Frameworks Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals. EFSA Journal 11:7.
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Thomas Peyret & Kannan Krishnan. (2012) Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans. Journal of Toxicology 2012, pages 1-22.
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Jerry L. CampbellJr.Jr., Rebecca A. Clewell, P. Robinan Gentry, Melvin E. Andersen & Harvey J. ClewellIIIIII. 2012. Computational Toxicology. Computational Toxicology 439 499 .
Shu Cheng & Frederic Y. Bois. (2011) A Mechanistic Modeling Framework for Predicting Metabolic Interactions in Complex Mixtures. Environmental Health Perspectives 119:12, pages 1712-1718.
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Yu-Mei Tan, Harvey Clewell, Jerry Campbell & Melvin Andersen. (2011) Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment. International Journal of Environmental Research and Public Health 8:5, pages 1613-1630.
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. 2010. Mixture Toxicity. Mixture Toxicity 229 269 .
Jerry L. CampbellJr.Jr., Kannan Krishnan, Harvey J. ClewellIIIIII & Melvin E. Andersen. 2010. Principles and Practice of Mixtures Toxicology. Principles and Practice of Mixtures Toxicology 125 157 .
Sami Haddad, Robert Tardif, Jonathan Boyd & Kannan Krishnan. 2010. Quantitative Modeling in Toxicology. Quantitative Modeling in Toxicology 83 105 .
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Kannan Krishnan, Sastry Isukapalli & Jonathan Boyd. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Hon‐Wing Leung. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
J. L. FlippinJ. M. HedgeM. J. DeVitoG. A. LeBlancK. M. Crofton. (2009) Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine. International Journal of Toxicology 28:5, pages 368-381.
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Ijaz S. Jamall & Calvin C. Willhite. (2008) Is benzene exposure from gasoline carcinogenic?. J. Environ. Monit. 10:2, pages 176-187.
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Sathanandam S. Anand, Jerry L. Campbell & Jeffrey W. Fisher. (2016) In Vitro Rat Hepatic Metabolism of n-Alkanes: Nonane, Decane, and Tetradecane. International Journal of Toxicology 26:4, pages 325-330.
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Charles A. Menzie, Margaret M. MacDonell & Moiz Mumtaz. (2007) A Phased Approach for Assessing Combined Effects from Multiple Stressors. Environmental Health Perspectives 115:5, pages 807-816.
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Robert De Woskin, Chadwick Thompson, Weihsueh Chiu, Paul Schlosser, Carolyn Smallwood, Jeff Swartout, Linda Teuschler & Allan Marcus. 2006. Toxicokinetics and Risk Assessment. Toxicokinetics and Risk Assessment 301 348 .
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Céline Brochot, János Tóth & Frédéric Y. Bois. (2005) Lumping in Pharmacokinetics. Journal of Pharmacokinetics and Pharmacodynamics 32:5-6, pages 719-736.
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G Mulder, I Meijerman, F Salmon, V Feron, R Hermus, J Groten, E Schoen & D Jonker. 2005. Food-Drug Synergy and Safety. Food-Drug Synergy and Safety 431 460 .
A. Q. Smith, J. L. Campbell, D. A. Keys & J. W. Fisher. (2016) Rat Tissue and Blood Partition Coefficients for n-Alkanes (C 8 to C 12 ) . International Journal of Toxicology 24:1, pages 35-41.
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James E. Dennison, Melvin E. Andersen, Harvey J. Clewell & Raymond S. H. Yang. (2004) Development of a Physiologically Based Pharmacokinetic Model for Volatile Fractions of Gasoline Using Chemical Lumping Analysis. Environmental Science & Technology 38:21, pages 5674-5681.
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Raymond S.H. Yang, Hisham A. El-Masri, Russell S. Thomas, Ivan D. Dobrev, James E. DennisonJr.Jr., Dong-Soon Bae, Julie A. Campain, Kai H. Liao, Brad Reisfeld, Melvin E. Andersen & Moiz Mumtaz. (2004) Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology. Environmental Toxicology and Pharmacology 18:2, pages 65-81.
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Melvin E. Andersen & James E. Dennison. (2004) Mechanistic approaches for mixture risk assessments—present capabilities with simple mixtures and future directions. Environmental Toxicology and Pharmacology 16:1-2, pages 1-11.
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James E Dennison, Melvin E Andersen, Ivan D Dobrev, Moiz M Mumtaz & Raymond S.H Yang. (2004) PBPK modeling of complex hydrocarbon mixtures: gasoline. Environmental Toxicology and Pharmacology 16:1-2, pages 107-119.
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David E. Leahy. (2004) Drug discovery information integration: virtual humans for pharmacokinetics. Drug Discovery Today: BIOSILICO 2:2, pages 78-84.
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