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Inhalation Toxicology
International Forum for Respiratory Research
Volume 16, 2004 - Issue 5
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Research Article

Chronic Inhalation Toxicity and Carcinogenicity Study on Potassium Octatitanate Fibers (TISMO) in Rats

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Pages 291-310 | Published online: 20 Oct 2008

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Seiya Sakai, Kousuke Inada, Akira K. Tanaka, David P. Kelly, Greg P. Sykes & K. P. Lee. (2010) Inhalation toxicity study of disk-shaped potassium octatitanate particles (Terracess TF) in rats following 90 days of aerosol exposure. Inhalation Toxicology 22:1, pages 56-68.
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Articles from other publishers (12)

David B. Warheit & Leonard S. Levy. (2021) Pulmonary bioassay studies with brake lining components - Nonfibrous potassium octatitanate - Terracess JS particles in rats. Food and Chemical Toxicology 153, pages 112292.
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Mohamed Abdelgied, Ahmed M. El-Gazzar, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Khaled Abbas Abdou, Satoru Takahashi, David B. Alexander & Hiroyuki Tsuda. (2019) Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration. Particle and Fibre Toxicology 16:1.
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Mohamed Abdelgied, Ahmed M. El-Gazzar, David B. Alexander, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Khaled Abbas Abdou, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Hiroyuki Tsuda & Satoru Takahashi. (2019) Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats. Archives of Toxicology 93:4, pages 909-920.
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Mohamed Abdelgied, Ahmed M. El-Gazzar, David B. Alexander, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hirotsugu Takase, Khaled Abbas Abdou, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Hiroyuki Tsuda & Satoru Takahashi. (2018) Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats. Cancer Science 109:7, pages 2164-2177.
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Gail Drummond, Ruth Bevan & Paul Harrison. (2016) A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. Regulatory Toxicology and Pharmacology 81, pages 89-105.
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Masanao Yokohira, Nozomi Hashimoto, Toshitaka Nakagawa, Yuko Nakano, Keiko Yamakawa, Sosuke Kishi, Shohei Kanie, Fumiko Ninomiya, Kousuke Saoo & Katsumi Imaida. (2015) Long-Term Chronic Toxicity and Mesothelial Cell Reactions Induced by Potassium Octatitanate Fibers (TISMO) in the Left Thoracic Cavity in A/J Female Mice. International Journal of Toxicology 34:4, pages 325-335.
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Sohail Ejaz, Gerry Amor Camer, Khaleeq Anwar & Muhammad Ashraf. (2014) Monitoring impacts of air pollution: PIXE analysis and histopathological modalities in evaluating relative risks of elemental contamination. Ecotoxicology 23:3, pages 357-369.
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Masanao Yokohira, Yuko Nakano, Keiko Yamakawa, Sosuke Kishi, Fumiko Ninomiya, Kousuke Saoo & Katsumi Imaida. (2013) Strain differences in pleural mesothelial cell reactions induced by potassium octatitanate fibers (TISMO) infused directly into the thoracic cavity. Experimental and Toxicologic Pathology 65:6, pages 925-932.
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MASANAO YOKOHIRA, NOZOMI HASHIMOTO, KEIKO YAMAKAWA, SATOSHI SUZUKI, KOUSUKE SAOO, TOSHIYA KUNO & KATSUMI IMAIDA. (2010) Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice. Oncology Letters 1:4, pages 589-594.
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Masanao Yokohira, Toshiya Kuno, Keiko Yamakawa, Nozomi Hashimoto, Fumiko Ninomiya, Satoshi Suzuki, Kousuke Saoo & Katsumi Imaida. (2009) An Intratracheal Instillation Bioassay System for Detection of Lung Toxicity Due to Fine Particles in F344 Rats. Journal of Toxicologic Pathology 22:1, pages 1-10.
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Masanao Yokohira, Hijiri Takeuchi, Keiko Yamakawa, Kousuke Saoo, Yoko Matsuda, Yu Zeng, Kyoko Hosokawa & Katsumi Imaida. (2007) Bioassay by intratracheal instillation for detection of lung toxicity due to fine particles in F344 male rats. Experimental and Toxicologic Pathology 58:4, pages 211-221.
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Helmut A Greim. (2004) Research needs to improve risk assessment of fiber toxicity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 553:1-2, pages 11-22.
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