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Inhalation Toxicology
International Forum for Respiratory Research
Volume 16, 2004 - Issue sup1
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Research Article

Hypertensive Rats are Susceptible to TLR4-Mediated Signaling Following Exposure to Combustion Source Particulate Matter

Peter S. Gilmour Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USACorrespondence[email protected]
,
Mette C. Schladweiler U.S. Environmental Protection Agency, Pulmonary Toxicology Branch, Experimental Toxicology Division, NHEERL, Durham, North Carolina, USA
,
Judy H. Richards U.S. Environmental Protection Agency, Pulmonary Toxicology Branch, Experimental Toxicology Division, NHEERL, Durham, North Carolina, USA
,
Allen D. Ledbetter U.S. Environmental Protection Agency, Pulmonary Toxicology Branch, Experimental Toxicology Division, NHEERL, Durham, North Carolina, USA
&
Urmila P. Kodavanti U.S. Environmental Protection Agency, Pulmonary Toxicology Branch, Experimental Toxicology Division, NHEERL, Durham, North Carolina, USA
Pages 5-18 | Published online: 20 Oct 2008

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Zhihua Wang, Junling Zhao, Ting Wang, Xiaohui Du & Jungang Xie. (2019) Fine-particulate matter aggravates cigarette smoke extract–induced airway inflammation via Wnt5a–ERK pathway in COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 979-994.
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Alex P. Carll, Najwa Haykal-Coates, Darrell W. Winsett, William H. Rowan$suffix/text()$suffix/text(), Mehdi S. Hazari, Allen D. Ledbetter, Abraham Nyska, Wayne E. Cascio, William P. Watkinson, Daniel L. Costa & Aimen K. Farraj. (2010) Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy. Inhalation Toxicology 22:5, pages 355-368.
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Bei Yu, Urmila P. Kodavanti, Minoru Takeuchi, Hanspeter Witschi & Kent E. Pinkerton. (2008) Acute Tobacco Smoke-Induced Airways Inflammation in Spontaneously Hypertensive Rats. Inhalation Toxicology 20:7, pages 623-633.
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J. Grace Wallenborn, MetteC. Schladweiler, Abraham Nyska, Jo Anne Johnson, Ronald Thomas, RichardH. Jaskot, JudyH. Richards, AllenD. Ledbetter & UrmilaP. Kodavanti. (2007) Cardiopulmonary Responses of Wistar Kyoto, Spontaneously Hypertensive, and Stroke-prone Spontaneously Hypertensive Rats to Particulate Matter (PM) Exposure. Journal of Toxicology and Environmental Health, Part A 70:22, pages 1912-1922.
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Preethi Sama, Thomas C. Long, Susan Hester, Julianne Tajuba, Joel Parker, Lung-Chi Chen & Bellina Veronesi. (2007) The Cellular and Genomic Response of an Immortalized Microglia Cell Line (BV2) to Concentrated Ambient Particulate Matter. Inhalation Toxicology 19:13, pages 1079-1087.
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Nachiket M. Godbole, Asif Alam Chowdhury, Neha Chataut & Shanjana Awasthi. (2022) Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury. Inflammation 45:6, pages 2142-2162.
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Lisa Kobos & Jonathan Shannahan. (2021) Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease. Experimental Biology and Medicine 246:7, pages 822-834.
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Urmila P. Kodavanti. (2019) Susceptibility Variations in Air Pollution Health Effects: Incorporating Neuroendocrine Activation. Toxicologic Pathology 47:8, pages 962-975.
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Olga Zolotareva, Olga V. Saik, Cassandra Königs, Elena Yu. Bragina, Irina A. Goncharova, Maxim B. Freidin, Victor E. Dosenko, Vladimir A. Ivanisenko & Ralf Hofestädt. (2019) Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports 9:1.
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Tatiana Drevytska, Roman Morhachov, Lesya Tumanovska, Georgiy Portnichenko, Vasyl Nagibin, Oleksiy Boldyriev, Tatiana Lapikova-Bryhinska, Veronika Gurianova, Borys Dons’koi, Maxim Freidin, Vladimir Ivanisenko, Elena Yu Bragina, Ralf Hofestädt & Victor Dosenko. (2018) shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma. Journal of Integrative Bioinformatics 15:4.
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Hyo Jeong Kim, Min Gi Choi, Moo Kyun Park & Young Rok Seo. (2017) Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure. Journal of Cancer Prevention 22:1, pages 6-15.
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Sandra C. Christiansen, Michael Schatz, Su-Jau Yang, Eunis Ngor, Wansu Chen & Bruce L. Zuraw. (2016) Hypertension and Asthma: A Comorbid Relationship. The Journal of Allergy and Clinical Immunology: In Practice 4:1, pages 76-81.
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Bin Luo, Hongxia Shi, Lina Wang, Yanrong Shi, Cheng Wang, Jingli Yang, Yaxiong Wan & Jingping Niu. (2014) Rat Lung Response to PM2.5 Exposure under Different Cold Stresses. International Journal of Environmental Research and Public Health 11:12, pages 12915-12926.
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Isabelle R. Miousse, Marie-Cécile G. Chalbot, Nükhet Aykin-Burns, Xiaoying Wang, Alexei Basnakian, Ilias G. Kavouras & Igor Koturbash. (2014) Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environmental and Molecular Mutagenesis 55:5, pages 428-435.
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Travis L. Knuckles, Richard Jaskot, Judy H. Richards, C. Andrew Miller, Allen Ledbetter, John McGee, William P. Linak & Kevin L. Dreher. (2013) Biokinetically-Based In Vitro Cardiotoxicity of Residual Oil Fly Ash: Hazard Identification and Mechanisms of Injury. Cardiovascular Toxicology 13:4, pages 426-437.
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ZORAN D. RISTOVSKI, BRANKA MILJEVIC, NICHOLAS C. SURAWSKI, LIDIA MORAWSKA, KWUN M. FONG, FELICIA GOH & IAN A. YANG. (2012) Respiratory health effects of diesel particulate matter. Respirology 17:2, pages 201-212.
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Zhuowei Li, Stavros Garantziotis, Paul W. Noble & John W. Hollingsworth. 2011. Allergens and Respiratory Pollutants. Allergens and Respiratory Pollutants 51 88 .
Marc E Rothenberg. (2010) Innate sensing of nickel. Nature Immunology 11:9, pages 781-782.
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Jinzhuo Zhao, Yuquan Xie, Xiaolin Qian, Rongfang Jiang & Weimin Song. (2010) Acute effects of fine particles on cardiovascular system: Differences between the spontaneously hypertensive rats and wistar kyoto rats. Toxicology Letters 193:1, pages 50-60.
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Rajiv K. Saxena, M. Ian Gilmour, Mette C. Schladweiler, Michael McClure, Michael Hays & Urmila P. Kodavanti. (2009) Differential Pulmonary Retention of Diesel Exhaust Particles in Wistar Kyoto and Spontaneously Hypertensive Rats. Toxicological Sciences 111:2, pages 392-401.
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Reuben Howden & Steven Kleeberger. 2006. Particle Toxicology. Particle Toxicology 275 284 .
Anne T Saber, Nicklas R Jacobsen, Jette Bornholdt, Sanna L Kjær, Marianne Dybdahl, Lotte Risom, Steffen Loft, Ulla Vogel & Håkan Wallin. (2006) Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor. Particle and Fibre Toxicology 3:1.
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Lindsay B Wichers, Allen D Ledbetter, John K McGee, Robert B Kellogg, William H RowanIIIIII, Julianne P Nolan, Daniel L Costa & William P Watkinson. (2006) A method for exposing rodents to resuspended particles using whole-body plethysmography. Particle and Fibre Toxicology 3:1.
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Urmila P. Kodavanti, Mette C. Schladweiler, Allen D. Ledbetter, John K. McGee, Leon Walsh, Peter S. Gilmour, Jerry W. Highfill, David Davies, Kent E. Pinkerton, Judy H. Richards, Kay Crissman, Debora Andrews & Daniel L. Costa. (2005) Consistent Pulmonary and Systemic Responses from Inhalation of Fine Concentrated Ambient Particles: Roles of Rat Strains Used and Physicochemical Properties. Environmental Health Perspectives 113:11, pages 1561-1568.
Crossref
Urmila Kodavanti & William Watkinson. 2005. Air Pollutants and the Respiratory Tract, Second Edition. Air Pollutants and the Respiratory Tract, Second Edition 75 133 .

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