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Inhalation Toxicology
International Forum for Respiratory Research
Volume 18, 2006 - Issue 4
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Research Article

Dose-Response and Threshold Analysis of Tumor Prevalence after Intratracheal Instillation of Six Types of Low- and High-Surface-Area Particles in a Chronic Rat Experiment

Peter Morfeld Institut und Poliklinik für Arbeitsmedizin, Sozialmedizin und Sozialhygiene der Universität zu Köln, Germany; Institut für Arbeitswissenschaften der RAG Aktiengesellschaft, Dortmund, Germany
,
Catrin Albrecht Particle Research, Institut für umweltmedizinische Forschung gGmbH (IUF) an der Heinrich-Heine-Universität, Düsseldorf, Germany
,
Wolfgang Drommer Institut für Pathologie, Arbeitsgruppe Elektronenmikroskopie, Stiftung Tierärztliche Hochschule, Hannover, Germany
&
Paul J. A. Borm Particle Research, Institut für umweltmedizinische Forschung gGmbH (IUF) an der Heinrich-Heine-Universität, Düsseldorf, Germany; Center of Expertise in Life Sciences, Hogeschool Zuyd, Heerlen, The Netherlands
Pages 215-225 | Received 22 Aug 2005, Accepted 17 Oct 2005, Published online: 06 Oct 2008

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J. Schneider, D. Walter, B. Brückel & K. Rödelsperger. (2013) Primary Particles and Their Agglomerate Formation as Modifying Risk Factors of Nonfibrous Nanosized Dust. Journal of Toxicology and Environmental Health, Part A 76:2, pages 131-141.
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Markus Roller. (2012) Time-to-tumor dose threshold analysis for intratracheal particle instillation-induced lung tumors in a large carcinogenicity study. International Journal of Occupational and Environmental Health 18:4, pages 278-291.
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Peter Morfeld. (2007) Letter to the Editor. Inhalation Toxicology 19:2, pages 195-195.
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Articles from other publishers (22)

Xiaoyan Lu, Junying Li, He Lou, Zeya Cao & Xiaohui Fan. (2021) Genome-Wide DNA Methylation Alterations and Potential Risk Induced by Subacute and Subchronic Exposure to Food-Grade Nanosilica in Mice. ACS Nano 15:5, pages 8225-8243.
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Paul J.A. Borm. (2022) The parallels between particle induced lung overload and particle induced periprosthetic osteolysis (PPOL). Open Research Europe 1, pages 16.
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Paul J.A. Borm. (2021) The parallels between particle induced lung overload and particle induced periprosthetic osteolysis (PPOL). Open Research Europe 1, pages 16.
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Peter Morfeld & Mei Yong. (2019) Effect of Occupational Exposure to Cyanuric Chloride on Respiratory Morbidity. Journal of Occupational & Environmental Medicine 61:1, pages e1-e11.
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Gretchen M. Bruce, Lisa M. Corey, Elizabeth N. Pearce, Lewis E. Braverman & Richard C. Pleus. (2018) Determination of Thresholds of Radioactive Iodine Uptake Response With Clinical Exposure to Perchlorate. Journal of Occupational & Environmental Medicine 60:4, pages e199-e206.
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Paul Borm, Flemming R Cassee & Günter Oberdörster. (2015) Lung particle overload: old school –new insights?. Particle and Fibre Toxicology 12:1.
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Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J Muranko, Ross Myerson & Robert J McCunney. (2015) Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans. Particle and Fibre Toxicology 12:1.
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Heinz-Peter Gelbke, Sibylle Gröters & Peter Morfeld. (2014) Lowest adverse effects concentrations (LOAECs) for formaldehyde exposure. Regulatory Toxicology and Pharmacology 70:1, pages 340-348.
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P. Morfeld & B. Noll. (2014) Cyanurchloridbelastung in ProduktionsbetriebenExposure to cyanuric chloride in production plants. Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie 64:2, pages 73-85.
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Peter Morfeld, Kenneth A. Mundt, Dirk Taeger, Karlheinz Guldner, Othmar Steinig & Brian G. Miller. (2013) Threshold Value Estimation for Respirable Quartz Dust Exposure and Silicosis Incidence Among Workers in the German Porcelain Industry. Journal of Occupational & Environmental Medicine 55:9, pages 1027-1034.
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Claudia Fruijtier-Pölloth. (2012) The toxicological mode of action and the safety of synthetic amorphous silica—A nanostructured material. Toxicology 294:2-3, pages 61-79.
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Kenneth A Mundt, Thomas Birk, William Parsons, Elisabeth Borsch-Galetke, Klaus Siegmund, Karyn Heavner & Karlheinz Guldner. (2011) Respirable Crystalline Silica Exposure–Response Evaluation of Silicosis Morbidity and Lung Cancer Mortality in the German Porcelain Industry Cohort. Journal of Occupational & Environmental Medicine 53:3, pages 282-289.
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P. Morfeld, B. Noll, S. F. Büchte, R. Derwall, V. Schenk, H. J. Bicker, H. Lenaerts, N. Schrader & D. Dahmann. (2009) Effect of dust exposure and nitrogen oxides on lung function parameters of German coalminers: a longitudinal study applying GEE regression 1974–1998. International Archives of Occupational and Environmental Health 83:4, pages 357-371.
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Thomas C. Erren, Christine B. Glende, Peter Morfeld & Claus Piekarski. (2008) Is exposure to silica associated with lung cancer in the absence of silicosis? A meta-analytical approach to an important public health question. International Archives of Occupational and Environmental Health 82:8, pages 997-1004.
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P.A. Valberg, J. Bruch & R.J. McCunney. (2009) Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?. Regulatory Toxicology and Pharmacology 54:1, pages 72-83.
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Stephen J. Klaine, Pedro J. J. Alvarez, Graeme E. Batley, Teresa F. Fernandes, Richard D. Handy, Delina Y. Lyon, Shaily Mahendra, Michael J. McLaughlin & Jamie R. Lead. (2009) Nanomaterials in the environment: Behavior, fate, bioavailability, and effects. Environmental Toxicology and Chemistry 27:9, pages 1825-1851.
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U. Mohr. (2007) Answer to: Morfeld P, Borm P. Letter to the Editor of Exp Toxicol Pathol of 19.09.2006 regarding the publication of Mohr et al. in Exp Toxicol Pathol 2006; 58(1):13–20. Experimental and Toxicologic Pathology 58:6, pages 409.
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Peter Morfeld & Paul Borm. (2007) . Experimental and Toxicologic Pathology 58:6, pages 407.
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Markus Roller. (2007) Differences between the data bases, statistical analyses, and interpretations of lung tumors of the 19-dust study – Two controversial views. Experimental and Toxicologic Pathology 58:6, pages 393-405.
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Thomas C. Erren, Peter Morfeld, Christine B. Glende & Claus Piekarski. (2007) Silica and Lung Cancer. Epidemiology 18:4, pages 521.
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Peter A. Valberg, Christopher M. Long & Sonja N. Sax. (2006) Integrating Studies on Carcinogenic Risk of Carbon Black: Epidemiology, Animal Exposures, and Mechanism of Action. Journal of Occupational and Environmental Medicine 48:12, pages 1291-1307.
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Ulrich Mohr, Heinrich Ernst, Markus Roller & Friedrich Pott. (2006) Pulmonary tumor types induced in Wistar rats of the so-called “19-dust study”. Experimental and Toxicologic Pathology 58:1, pages 13-20.
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