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Inhalation Toxicology
International Forum for Respiratory Research
Volume 18, 2006 - Issue 6
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Research Article

Acute Lung Injury Following Inhalation Exposure to Nerve Agent VX in Guinea Pigs

Benjamin S. Wright Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Peter E. Rezk Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Jacob R. Graham Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Keith E. Steele Divison of Pathology, Department of Immunohistochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Richard K. Gordon Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
,
Alfred M. Sciuto Medical Toxicology Branch, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
&
Madhusoodana P. Nambiar Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Pages 437-448 | Received 26 Aug 2005, Accepted 10 Dec 2005, Published online: 06 Oct 2008

Citations (30)

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Shira Chapman, Shlomi Lazar, Rellie Gez, Ishai Rabinovitz, Guy Yaakov & Ettie Grauer. (2019) Lung damage following whole body, but not intramuscular, exposure to median lethality dose of sarin: findings in rats and guinea pigs. Inhalation Toxicology 31:5, pages 203-211.
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Alfred M. Sciuto & Xinqi Peng. (2018) Pulmonary toxicity following inhalation exposure to VX in anesthetized rats: Possible roles for compromised immunity and oxidative stress-induced lung injury. Experimental Lung Research 44:8-9, pages 379-396.
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Devyani Swami, Ruchi Yadav, A.S.B. Bhaskar, A. Soni, D.P. Nagar, J. Acharya, H.N. Karade, K.P. Singh & Pravin Kumar. (2018) Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice. Inhalation Toxicology 30:7-8, pages 287-298.
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Michael W. Perkins, Benjamin Wong, Ashley Rodriguez, Jennifer Devorak & Alfred M. Sciuto. (2015) Measurement of various respiratory dynamics parameters following acute inhalational exposure to soman vapor in conscious rats. Inhalation Toxicology 27:9, pages 432-439.
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Xinqi Peng, Michael W. Perkins, Jannitt Simons, Alicia M. Witriol, Ashley M. Rodriguez, Brittany M. Benjamin, Jennifer Devorak & Alfred M. Sciuto. (2014) Acute pulmonary toxicity following inhalation exposure to aerosolized VX in anesthetized rats. Inhalation Toxicology 26:7, pages 371-379.
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Daniel J. Angelini, Russell M. Dorsey, Kristen L. Willis, Charles Hong, Robert A. Moyer, Jonathan Oyler, Neil S. Jensen & Harry Salem. (2013) Chemical warfare agent and biological toxin-induced pulmonary toxicity: could stem cells provide potential therapies?. Inhalation Toxicology 25:1, pages 37-62.
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Magnus M. Che, Soma Chanda, Jian Song, Bhupendra P. Doctor, Peter E. Rezk, Praveena Sabnekar, Michael W. Perkins, Alfred M. Sciuto & Madhusoodana P. Nambiar. (2011) Aerosolized scopolamine protects against microinstillation inhalation toxicity to sarin in guinea pigs. Toxicology Mechanisms and Methods 21:6, pages 463-472.
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Alexandre M. Katos, Michele Conti, Theodore S. Moran, Thomas W. Chon, Richard K. Gordon, Alfred M. Sciuto, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2009) Acute microinstillation inhalation exposure to soman induces changes in respiratory dynamics and functions in guinea pigs. Inhalation Toxicology 21:7, pages 648-657.
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Magnus M. Che, Michele Conti, Megan Boylan, Alfred M. Sciuto, Richard K. Gordon & Madhusoodana P. Nambiar. (2008) Blood and Bronchoalveolar Lavage Fluid Acetylcholinesterase Levels Following Microinstillation Inhalation Exposure to Sarin in Guinea Pigs. Inhalation Toxicology 20:9, pages 821-828.
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M. P. Nambiar, R. K. Gordon, T. S. Moran, S. M. Richards & A. M. Sciuto. (2007) A Simple Method for Accurate Endotracheal Placement of an Intubation Tube in Guinea Pigs to Assess Lung Injury Following Chemical Exposure. Toxicology Mechanisms and Methods 17:7, pages 385-392.
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Peter E. Rezk, Jacob R. Graham, Theodore S. Moran, Richard K. Gordon, Alfred M. Sciuto, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2007) Acute Toxic Effects of Nerve Agent VX on Respiratory Dynamics and Functions Following Microinsillation Inhalation Exposure in Guinea Pigs. Inhalation Toxicology 19:3, pages 291-302.
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Alfred M. Sciuto & Urmila P. Kodavanti. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 515 544 .
E. Bloch-Shilderman, G. Yacov, L. Cohen, I. Egoz, H. Gutman, R. Gez, I. Rabinovitz & U. Nili. (2019) Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats. Archives of Toxicology 93:5, pages 1365-1384.
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Yunbiao Wang, ByungHoon Kim, Ashley Walker, Shayla Williams, Ashley Meeks, Yong-Jin Lee & Seong S. Seo. (2019) Cytotoxic effects of parathion, paraoxon, and their methylated derivatives on a mouse neuroblastoma cell line NB41A3. Fundamental Toxicological Sciences 6:2, pages 45-56.
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Fei He, Jun Wang, Yao Liu, Xiaojing Wang, Nan Cai, Chao Wu & Qingling Gao. (2018) Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-κB in lung injury caused by dichlorvos poisoning. Biomedicine & Pharmacotherapy 106, pages 1404-1411.
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Julia Herbert, Horst Thiermann, Franz Worek & Timo Wille. (2017) Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning. Toxicology 389, pages 94-100.
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Daniel J. Angelini, Robert A. Moyer, Stephanie Cole, Kristen L. Willis, Jonathan Oyler, Russell M. Dorsey & Harry Salem. (2015) The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells. International Journal of Toxicology 34:5, pages 433-441.
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Alfred M. Sciuto & Urmila P. Kodavanti. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 489 518 .
Elspeth J. Hulse, James O. J. Davies, A. John Simpson, Alfred M. Sciuto & Michael Eddleston. (2014) Respiratory Complications of Organophosphorus Nerve Agent and Insecticide Poisoning. Implications for Respiratory and Critical Care. American Journal of Respiratory and Critical Care Medicine 190:12, pages 1342-1354.
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Nimrod Ophir, Erez Ramaty, Inbal Rajuan-Galor, Yossi Rosman, Ophir Lavon, Shai Shrot, Arthur Shiyovich, Michael Huerta-Hartal, Michael Kassirer, Sonia Vaida & Luis Gaitini. (2014) Airway control in case of a mass toxicological event: superiority of second-generation supraglottic airway devices. The American Journal of Emergency Medicine 32:12, pages 1445-1449.
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Michael W. Perkins, Benjamin Wong, Ashley Rodriguez, Jennifer L. Devorak, Derron A. Alves, Gleeson Murphy & Alfred M. Sciuto. (2013) Inhalation toxicity of soman vapor in non-anesthetized rats: A preliminary assessment of inhaled bronchodilator or steroid therapy. Chemico-Biological Interactions 206:3, pages 452-461.
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Michael W. Perkins, Zdenka Pierre, Peter Rezk, Jian Song, Samuel Oguntayo, Venee Morthole, Alfred M. Sciuto, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2011) Protective Effects of Aerosolized Scopolamine Against Soman-Induced Acute Respiratory Toxicity in Guinea Pigs. International Journal of Toxicology 30:6, pages 639-649.
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Michael W. Perkins, Zdenka Pierre, Peter Rezk, Jian Song, Samuel Oguntayo, Alfred M. Sciuto, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2011) Acute Changes in Pulmonary Function Following Microinstillation Inhalation Exposure to Soman in Nonatropenized Guinea Pigs. International Journal of Toxicology 30:3, pages 348-357.
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Michael W. Perkins, Zdenka Pierre, Peter Rezk, Praveena Sabnekar, Kareem Kabra, Soma Chanda, Samuel Oguntayo, Alfred M. Sciuto, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2010) Acute respiratory toxicity following inhalation exposure to soman in guinea pigs. Toxicology and Applied Pharmacology 245:2, pages 171-178.
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Michele L. ContiMagnus M. CheMegan BoylanAlfred M. SciutoRichard K. GordonMadhusoodana P. Nambiar. (2009) Acute Microinstillation Inhalation Exposure to Sarin Induces Changes in Respiratory Dynamics and Functions in Guinea Pigs. International Journal of Toxicology 28:5, pages 436-447.
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David GrossDavid R. Gross. 2009. Animal Models in Cardiovascular Research. Animal Models in Cardiovascular Research 17 54 .
Jianguo Zhuang, Fadi Xu, Matthew J. Campen, Cancan Zhang, Juan C. Pena-Philippides & Mohan L. Sopori. (2008) Inhalation of the nerve gas sarin impairs ventilatory responses to hypercapnia and hypoxia in rats. Toxicology and Applied Pharmacology 232:3, pages 440-447.
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David Rocksén, Daniel Elfsmark, Victoria Heldestad, Karin Wallgren, Gudrun Cassel & Ann Göransson Nyberg. (2008) An animal model to study health effects during continuous low-dose exposure to the nerve agent VX. Toxicology 250:1, pages 32-38.
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Alexandre M. KatosMichele L. Conti, Theodore S. Moran, Richard K. Gordon, Bhupendra P. Doctor, Alfred M. Sciuto & Madhusoodana P. Nambiar. (2016) Abdominal bloating and irritable bowel syndrome like symptoms following microinstillation inhalation exposure to chemical warfare nerve agent VX in guinea pigs. Toxicology and Industrial Health 23:4, pages 231-240.
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Madhusoodana P. Nambiar, Richard K. Gordon, Peter E. Rezk, Alexander M. Katos, Nikolai A. Wajda, Theodore S. Moran, Keith E. Steele, Bhupendra P. Doctor & Alfred M. Sciuto. (2007) Medical countermeasure against respiratory toxicity and acute lung injury following inhalation exposure to chemical warfare nerve agent VX. Toxicology and Applied Pharmacology 219:2-3, pages 142-150.
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