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Inhalation Toxicology
International Forum for Respiratory Research
Volume 18, 2006 - Issue 14
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Research Article

Effects of Whole-Body VX Vapor Exposure on Lethality in Rats

B. J. Benton U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
J. M. McGuire U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
D. R. Sommerville U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
P. A. Dabisch U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
E. M. Jakubowski Jr. U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
K. L. Matson U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
R. J. Mioduszewski U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
,
S. A. Thomson U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA
&
C. L. Crouse Science Applications International Corporation, Abingdon, Maryland, USA
 show all
Pages 1091-1099 | Received 21 Jun 2006, Accepted 23 Jul 2006, Published online: 06 Oct 2008

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Xinqi Peng, Michael W. Perkins, Jannitt Simons, Alicia M. Witriol, Ashley M. Rodriguez, Brittany M. Benjamin, Jennifer Devorak & Alfred M. Sciuto. (2014) Acute pulmonary toxicity following inhalation exposure to aerosolized VX in anesthetized rats. Inhalation Toxicology 26:7, pages 371-379.
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Benjamin Wong, Michael W. Perkins, Mariton D. Santos, Ashley M. Rodriguez, Gleeson Murphy & Alfred M. Sciuto. (2013) Development of a model for nerve agent inhalation in conscious rats. Toxicology Mechanisms and Methods 23:7, pages 537-547.
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Annetta Watson, Fredrick Dolislager, Linda Hall, Ellen Raber, VeroniqueD. Hauschild & AdamH. Love. (2011) Developing Health-Based Pre-Planning Clearance Goals for Airport Remediation Following a Chemical Terrorist Attack: Decision Criteria for Multipathway Exposure Routes. Human and Ecological Risk Assessment: An International Journal 17:1, pages 57-121.
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Annetta Watson, Linda Hall, Ellen Raber, VeroniqueD. Hauschild, Fredrick Dolislager, AdamH. Love & M. Leslie Hanna. (2011) Developing Health-Based Pre-Planning Clearance Goals for Airport Remediation Following Chemical Terrorist Attack: Introduction and Key Assessment Considerations. Human and Ecological Risk Assessment: An International Journal 17:1, pages 2-56.
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Articles from other publishers (17)

E. Wigenstam, E. Forsberg, A. Bucht & L. Thors. (2021) Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and Applied Pharmacology 419, pages 115512.
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Robert A. Young & Annetta Watson. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 97 126 .
E. Bloch-Shilderman, G. Yacov, L. Cohen, I. Egoz, H. Gutman, R. Gez, I. Rabinovitz & U. Nili. (2019) Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats. Archives of Toxicology 93:5, pages 1365-1384.
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E. Bloch-Shilderman, I. Rabinovitz, I. Egoz, G. Yacov, N. Allon & U. Nili. (2017) Determining a threshold sub-acute dose leading to minimal physiological alterations following prolonged exposure to the nerve agent VX in rats. Archives of Toxicology 92:2, pages 873-892.
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Linnzi K.M. Wright, Robyn B. Lee, Edward D. Clarkson & Lucille A. Lumley. (2016) Female rats are less susceptible during puberty to the lethal effects of percutaneous exposure to VX. Toxicology Reports 3, pages 895-899.
Crossref
Linnzi K.M. Wright, Robyn B. Lee, Nicole M. Vincelli, Christopher E. Whalley & Lucille A. Lumley. (2016) Comparison of the lethal effects of chemical warfare nerve agents across multiple ages. Toxicology Letters 241, pages 167-174.
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Carl D. Smith, Linnzi K.M. Wright, Gregory E. Garcia, Robyn B. Lee & Lucille A. Lumley. (2015) Hormone-dependence of sarin lethality in rats: Sex differences and stage of the estrous cycle. Toxicology and Applied Pharmacology 287:3, pages 253-257.
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Annetta Watson, Dennis Opresko, Robert A. Young, Veronique Hauschild, Joseph King & Kulbir Bakshi. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 87 109 .
Vibha Verma, Qiming J. Yu & Des W. Connell. (2014) Evaluation of effects of long term exposure on lethal toxicity with mammals. Environmental Pollution 185, pages 234-239.
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J. Leppert, G. Horner, F. Rietz, J. Ringer, P. Schulze Lammers & P. Boeker. (2012) Near real time detection of hazardous airborne substances. Talanta 101, pages 440-446.
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Lawrence M. Schopfer & Oksana Lockridge. (2012) Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts. Drug Testing and Analysis 4:3-4, pages 246-261.
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Deena S. Disraelly, Terri J. Walsh, Robert A. Zirkle & Carl A. Curling. (2011) A new methodology for estimating nerve agent (Sarin (GB)/VX) casualties as a function of time: Defining the Human Response Injury Profile nerve agent methodology. Journal of Chemical Health & Safety 18:5, pages 5-11.
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William P. Fawcett, Yasco Aracava, Michael Adler, Edna F. R. Pereira & Edson X. Albuquerque. (2009) Acute Toxicity of Organophosphorus Compounds in Guinea Pigs Is Sex- and Age-Dependent and Cannot Be Solely Accounted for by Acetylcholinesterase Inhibition. Journal of Pharmacology and Experimental Therapeutics 328:2, pages 516-524.
Crossref
Annetta Watson, Dennis Opresko, Robert Young, Veronique Hauschild, Joseph King & Kulbir Bakshi. 2009. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 43 67 .
Eugenia Bloch-Shilderman, Ishai Rabinovitz, Inbal Egoz, Lily Raveh, Nahum Allon, Ettie Grauer, Eran Gilat & Ben Avi Weissman. (2008) Subchronic exposure to low-doses of the nerve agent VX: Physiological, behavioral, histopathological and neurochemical studies. Toxicology and Applied Pharmacology 231:1, pages 17-23.
Crossref
Stanley Hulet, Robert Mioduszewski, Robert Kristovich & Paul Dabisch. 2007. Chemical Warfare Agents. Chemical Warfare Agents.
Raymond F. Genovese, Bernard J. Benton, Esther H. Lee, Sara J. Shippee & E. Michael Jakubowski. (2007) Behavioral and biochemical evaluation of sub-lethal inhalation exposure to VX in rats. Toxicology 232:1-2, pages 109-118.
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