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Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue 10
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Research Article

Workshop Summary: Phosgene-Induced Pulmonary Toxicity Revisited: Appraisal of Early and Late Markers of Pulmonary Injury From Animal Models With Emphasis on Human Significance

J. Pauluhn Bayer Schering Pharma, Wuppertal, Germany
,
A. Carson Health Science Center at Houston, University of Texas, Houston, Texas, USA
,
D. L. Costa National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
,
T. Gordon NYU School of Medicine, Tuxedo, New York, USA
,
U. Kodavanti Bayer Schering Pharma, Wuppertal, Germany
,
J. A. Last Department of Medicine, School of Medicine, University of California, Davis, California, USA
,
M. A. Matthay Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California, USA
,
K. E. Pinkerton Department of Pediatrics, School of Medicine, University of California, Davis, California, USA
&
A. M. Sciuto Analytical Toxicology Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
 show all
Pages 789-810 | Received 03 Mar 2007, Accepted 12 Apr 2007, Published online: 06 Oct 2008

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Dai-Kun He, Jun-Feng Chen, Yi-Ru Shao, Fang-Qing Zhou & Jie Shen. (2018) Adenovirus-delivered angiopoietin-1 ameliorates phosgene-induced acute lung injury via inhibition of NLRP3 inflammasome activation. Inhalation Toxicology 30:4-5, pages 187-194.
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Dorian S. Olivera, Heidi Hoard-Fruchey & Alfred M. Sciuto. (2017) Evaluation of an in vitro screening model to assess phosgene inhalation injury. Toxicology Mechanisms and Methods 27:1, pages 45-51.
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Jennifer L. Plahovinsak, Mark R. Perry, Katherine A. Knostman, Robert Segal & Michael C. Babin. (2015) Characterization of a nose-only inhaled phosgene acute lung injury mouse model . Inhalation Toxicology 27:14, pages 832-840.
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Junfeng Chen, Yiru Shao, Guoxiong Xu, ChitChoon Lim, Jun Li, Daojian Xu & Jie Shen. (2015) Bone marrow-derived mesenchymal stem cells attenuate phosgene-induced acute lung injury in rats. Inhalation Toxicology 27:5, pages 254-261.
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Jie Shen, Jing Wang, Yi-Ru Shao, Dai-Kun He, Lin Zhang, Lubna Nadeem & Guoxiong Xu. (2013) Adenovirus-delivered angiopoietin-1 treatment for phosgene-induced acute lung injury. Inhalation Toxicology 25:5, pages 272-279.
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Daniel J. Angelini, Russell M. Dorsey, Kristen L. Willis, Charles Hong, Robert A. Moyer, Jonathan Oyler, Neil S. Jensen & Harry Salem. (2013) Chemical warfare agent and biological toxin-induced pulmonary toxicity: could stem cells provide potential therapies?. Inhalation Toxicology 25:1, pages 37-62.
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Wen-Li Li, Chun-Xu Hai & Jürgen Pauluhn. (2011) Inhaled nitric oxide aggravates phosgene model of acute lung injury. Inhalation Toxicology 23:13, pages 842-852.
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Dylan W. de Lange & Jan Meulenbelt. (2011) Do corticosteroids have a role in preventing or reducing acute toxic lung injury caused by inhalation of chemical agents?. Clinical Toxicology 49:2, pages 61-71.
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Jürgen Pauluhn. (2011) Acute nose-only inhalation exposure of rats to di- and triphosgene relative to phosgene. Inhalation Toxicology 23:2, pages 65-73.
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Jürgen Pauluhn & Chun Xue Hai. (2011) Attempts to counteract phosgene-induced acute lung injury by instant high-dose aerosol exposure to hexamethylenetetramine, cysteine or glutathione. Inhalation Toxicology 23:1, pages 58-64.
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Christopher Grainge & Paul Rice. (2010) Management of phosgene-induced acute lung injury. Clinical Toxicology 48:6, pages 497-508.
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Lin Ji, Rui Liu, Xiao Di Zhang, Hong Li Chen, Hua Bai, Xin Wang, Hai Long Zhao, Xin Liang & Chun Xu Hai. (2010) N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression. Inhalation Toxicology 22:7, pages 535-542.
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Chao Cao, Lin Zhang & Jie Shen. (2022) Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies. Frontiers in Immunology 13.
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Chaoyuan Jin, Fangqing Zhou, Lin Zhang & Jie Shen. (2020) Overexpression of heat shock protein 70 enhanced mesenchymal stem cell treatment efficacy in phosgene‐induced acute lung injury. Journal of Biochemical and Molecular Toxicology 34:8.
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Sa Luo, Jürgen Pauluhn, Hubert Trübel & Chen Wang. (2014) Corticosteroids found ineffective for phosgene-induced acute lung injury in rats. Toxicology Letters 229:1, pages 85-92.
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C. Grainge, R. Brown, B. Jugg, A. Smith, T. Mann, J. Jenner, P. Rice & D. Parkhouse. (2009) Early Treatment with Nebulised Salbutamol Worsens Physiological Measures and Does Not Improve Survival Following Phosgene Induced Acute Lung Injury. Journal of the Royal Army Medical Corps 155:2, pages 105-109.
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