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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 3
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Research Article

Combination Treatment with High-Dose Vitamin C and Alpha-Tocopherol does not Enhance Respiratory-Tract Lining Fluid Vitamin C Levels in Asthmatics

Michelle Hernandez The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
,
Haibo Zhou
,
Bingqing Zhou
,
Carole Robinette The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
,
Kay Crissman U. S. Environmental Protection Agency Experimental Toxicology Division, Research Triangle Park, North Carolina, USA
,
Gary Hatch U. S. Environmental Protection Agency Experimental Toxicology Division, Research Triangle Park, North Carolina, USA
,
Neil E Alexis The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
&
David Peden The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, North CarolinaCorrespondence[email protected]
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Pages 173-181 | Received 13 Feb 2008, Accepted 22 Apr 2008, Published online: 01 Feb 2009

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Shahabeddin Rezaei, Nima Rezaei, Maryam Mahmoudi & Zahra Aryan. (2017) Is there sufficient evidence to support the use of vitamin supplements in the asthmatic patient?. Expert Review of Respiratory Medicine 11:11, pages 851-853.
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Alie de Boer, Wouter R. P. H. van de Worp, Geja J. Hageman & Aalt Bast. (2017) The effect of dietary components on inflammatory lung diseases – a literature review. International Journal of Food Sciences and Nutrition 68:7, pages 771-787.
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Articles from other publishers (20)

Dominika Zajac & Piotr Wojciechowski. (2023) The Role of Vitamins in the Pathogenesis of Asthma. International Journal of Molecular Sciences 24:10, pages 8574.
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Joan M. Cook-Mills, Samantha H. Averill & Jacquelyn D. Lajiness. (2022) Asthma, allergy and vitamin E: Current and future perspectives. Free Radical Biology and Medicine 179, pages 388-402.
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Juan Li, Hang Li, Haibin Li, Weili Guo, Zhen An, Xiang Zeng, Wen Li, Huijun Li, Jie Song & Weidong Wu. (2019) Amelioration of PM2.5-induced lung toxicity in rats by nutritional supplementation with fish oil and Vitamin E. Respiratory Research 20:1.
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C. PanebiancoF. Bou Nasser EddineG. ForlaniG. PalmieriL. TatangeloA. VillaniL. XuR. AccollaV. Pazienza. (2019) Probiotic Bifidobacterium lactis , anti-oxidant vitamin E/C and anti-inflammatory dha attenuate lung inflammation due to pm2.5 exposure in mice . Beneficial Microbes 10:1, pages 69-75.
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Joan M. Cook-Mills. 2019. Vitamin E in Human Health. Vitamin E in Human Health 345 370 .
Eric Maimon, Uri Samuni & Sara Goldstein. (2018) Studying mechanism of radical reactions: From radiation to nitroxides as research tools. Radiation Physics and Chemistry 143, pages 14-19.
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Joan M. Cook-Mills. 2017. Nutrition and Functional Foods for Healthy Aging. Nutrition and Functional Foods for Healthy Aging 167 188 .
René Lutter, Bas van Lieshout & Caterina Folisi. (2015) Reduced Antioxidant and Cytoprotective Capacity in Allergy and Asthma. Annals of the American Thoracic Society 12:Supplement 2, pages S133-S136.
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Miri Assayag, Sara Goldstein, Amram Samuni & Neville Berkman. (2015) Cyclic nitroxide radicals attenuate inflammation and Hyper-responsiveness in a mouse model of allergic asthma. Free Radical Biology and Medicine 87, pages 148-156.
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N. Larsson, G. D. Rankin, E. M. Bicer, E. Roos-Engstrand, J. Pourazar, A. Blomberg, I. S. Mudway & A. F. Behndig. (2015) Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study. BMJ Open 5:4, pages e006979-e006979.
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Mark Wilkinson, Anna Hart, Stephen J Milan & Karnam Sugumar. (2014) Vitamins C and E for asthma and exercise-induced bronchoconstriction. Cochrane Database of Systematic Reviews 2018:6.
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James G. Wagner, Neil P. Birmingham, Daven Jackson-Humbles, Qing Jiang, Jack R. Harkema & David B. Peden. (2014) Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats. Free Radical Biology and Medicine 68, pages 101-109.
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Koa Hosoki, Renu Gandhe, Istvan Boldogh & Sanjiv Sur. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 3239 3266 .
Hiam Abdala-Valencia, Sergejs Berdnikovs & Joan Cook-Mills. (2013) Vitamin E Isoforms as Modulators of Lung Inflammation. Nutrients 5:11, pages 4347-4363.
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Stephen J Milan, Anna Hart & Mark Wilkinson. (2013) Vitamin C for asthma and exercise-induced bronchoconstriction. Cochrane Database of Systematic Reviews 2018:6.
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Shu-Chen Lee, Yao-Hsu Yang, Shao-Yuan Chuang, Shih-Yi Huang & Wen-Harn Pan. (2012) Reduced medication use and improved pulmonary function with supplements containing vegetable and fruit concentrate, fish oil and probiotics in asthmatic school children: a randomised controlled trial. British Journal of Nutrition 110:1, pages 145-155.
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Mohamed Ahmed Youssef, Sabry Ahmed El-khodery & Hussam Mohamed Mohamed Ibrahim. (2013) Effect of Selenium and Vitamin C on Clinical Outcomes, Trace Element Status, and Antioxidant Enzyme Activity in Horses with Acute and Chronic Lower Airway Disease. A Randomized Clinical Trial. Biological Trace Element Research 152:3, pages 333-342.
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Marianne Geiser, John C. Lay, William D. Bennett, Haibo Zhou, Xiaoyan Wang, David B. Peden & Neil E. Alexis. (2013) Effects of ex vivo γ-Tocopherol on Airway Macrophage Function in Healthy and Mild Allergic Asthmatics. Journal of Innate Immunity 5:6, pages 613-624.
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Melinda Braskett & Marc A Riedl. (2010) Novel antioxidant approaches to the treatment of upper airway inflammation. Current Opinion in Allergy & Clinical Immunology 10:1, pages 34-41.
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Young-Joo JeongJin-Hee KimJae Seung KangWang Jae LeeYoung-il Hwang. (2010) Mega-dose vitamin C attenuated lung inflammation in mouse asthma model. Anatomy & Cell Biology 43:4, pages 294.
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