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Inhalation Toxicology
International Forum for Respiratory Research
Volume 30, 2018 - Issue 4-5
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Research Article

Adenovirus-delivered angiopoietin-1 ameliorates phosgene-induced acute lung injury via inhibition of NLRP3 inflammasome activation

Dai-Kun HeCenter of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Center of Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Research Centre for Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, ChinaView further author information
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Jun-Feng ChenCenter of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Center of Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Research Centre for Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, ChinaView further author information
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Yi-Ru ShaoCenter of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Center of Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Research Centre for Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, ChinaORCID Iconhttp://orcid.org/0000-0002-6593-6761View further author information
ORCID Icon,
Fang-Qing ZhouCenter of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Center of Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Research Centre for Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, ChinaView further author information
&
Jie ShenCenter of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Center of Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, China; ;Medical Research Centre for Chemical Injury, Emergency and Critical Care, Jinshan Hospital, Fudan University, Shanghai, ChinaCorrespondence[email protected]
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Pages 187-194 | Received 27 Jan 2018, Accepted 20 Jun 2018, Published online: 26 Sep 2018

Citations (10)

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Ning Xu, Yiru Shao, Kaili Ye, Yubei Qu, Obulkasim Memet, Daikun He & Jie Shen. (2019) Mesenchymal stem cell-derived exosomes attenuate phosgene-induced acute lung injury in rats. Inhalation Toxicology 31:2, pages 52-60.
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Articles from other publishers (9)

Jury Ju. Ivnitsky, Timur V. Schäfer, Vladimir L. Rejniuk & Alexandr I. Golovko. (2022) Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications. Journal of Applied Toxicology 43:1, pages 47-65.
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Chao Cao, Lin Zhang & Jie Shen. (2022) Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies. Frontiers in Immunology 13.
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Qianying Lu, Siyu Huang, Xiangyan Meng, Jianfeng Zhang, Sifan Yu, Junfeng Li, Mingyu Shi, Haojun Fan & Yanmei Zhao. (2021) Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy. International Journal of Molecular Sciences 22:20, pages 10933.
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Xiuhong Wang, Shibiao Chen, Lili Zhao & Xiaoyun Shi. (2021) Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways. International Immunopharmacology 97, pages 107506.
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Chaojin Chen, Yufeng He, Yawei Feng, Weilong Hong, Gangjian Luo & Zhiqiang Ye. (2021) Long non-coding RNA review and implications in acute lung inflammation. Life Sciences 269, pages 119044.
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Jared Radbel, Debra L. Laskin, Jeffrey D. Laskin & Howard M. Kipen. (2020) Disease‐modifying treatment of chemical threat agent–induced acute lung injury. Annals of the New York Academy of Sciences 1480:1, pages 14-29.
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Dai-Kun He, Ning Xu, Yi-Ru Shao & Jie Shen. (2020) NLRP3 gene silencing ameliorates phosgene-induced acute lung injury in rats by inhibiting NLRP3 inflammasome and proinflammatory factors, but not anti-inflammatory factors. The Journal of Toxicological Sciences 45:10, pages 625-637.
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Yun Li, Duanyi Song, Fanyan Bo, Min Deng & Xuefang Tang. (2019) Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABAA receptor α4-subunit. Biomedicine & Pharmacotherapy 118, pages 109239.
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Jin Tang, Yungai Li, Jianqiang Wang, Qiong Wu & Hongli Yan. (2018) Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain‐, leucine‐rich repeat‐, and pyd‐containing protein 3 inflammasome and the nuclear factor‐κB pathway after Mycoplasma pneumoniae infection . Journal of Cellular Biochemistry 120:6, pages 10137-10144.
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