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Inhalation Toxicology
International Forum for Respiratory Research
Volume 31, 2019 - Issue 13-14
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Research Articles

Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

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Pages 468-483 | Received 11 Jun 2019, Accepted 09 Jan 2020, Published online: 28 Jan 2020

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J. L. CampbellJr.Jr., H. J. ClewellIIIIII, C. Van Landingham, P. R. Gentry & M. E. Andersen. (2023) Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene. Frontiers in Pharmacology 14.
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Rebecca A. Clewell & Harvey J. ClewellIIIIII. 2003. Patty's Toxicology. Patty's Toxicology 1 18 .
Constance A. Mitchell, Natalie Burden, Mark Bonnell, Markus Hecker, Thomas H. Hutchinson, Magdalena Jagla, Carlie A. LaLone, Laurent Lagadic, Scott G. Lynn, Bryon Shore, You Song, Sara M. Vliet, James R. Wheeler & Michelle R. Embry. (2023) New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians. Environmental Toxicology and Chemistry 42:4, pages 757-777.
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Rory P. Conolly, Harvey J. Clewell, Martha M. Moore, Jerry L. Campbell, Wanyun Cheng & R. Robinan Gentry. (2023) PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol. Frontiers in Pharmacology 14.
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Laura N. Vandenberg, Swati D. G. Rayasam, Daniel A. Axelrad, Deborah H. Bennett, Phil Brown, Courtney C. Carignan, Nicholas Chartres, Miriam L. Diamond, Rashmi Joglekar, Bhavna Shamasunder, Kristin Shrader-Frechette, Wilma A. Subra, Ken Zarker & Tracey J. Woodruff. (2023) Addressing systemic problems with exposure assessments to protect the public’s health. Environmental Health 21:S1.
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Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen & Scott D. Slattery. (2022) NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene. Toxicology 481, pages 153340.
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Xiaoqing Chang, Yu-Mei Tan, David G. Allen, Shannon Bell, Paul C. Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti J. Hakkinen, Shruti V. Kabadi, Nicole C. Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather A. Pangburn, Elijah J. Petersen, Emily N. Reinke, Alexandre J. S. Ribeiro, Nisha Sipes, Lisa M. Sweeney, John F. Wambaugh, Ronald Wange, Barbara A. Wetmore & Moiz Mumtaz. (2022) IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making. Toxics 10:5, pages 232.
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Kaixiang Zhou, Kun Mi, Wenjin Ma, Xiangyue Xu, Meixia Huo, Samah Attia Algharib, Yuanhu Pan, Shuyu Xie & Lingli Huang. (2021) Application of physiologically based pharmacokinetic models to promote the development of veterinary drugs with high efficacy and safety. Journal of Veterinary Pharmacology and Therapeutics 44:5, pages 663-678.
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Melvin E. Andersen, Pankajini Mallick, Harvey J. ClewellIIIIII, Miyoung Yoon, Geary W. Olsen & Matthew P. Longnecker. (2021) Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures. Environmental Research 197, pages 111183.
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Sonja N Sax, P. Robinan Gentry, Cynthia Van Landingham, Harvey J. Clewell & Kenneth A. Mundt. (2019) Extended Analysis and Evidence Integration of Chloroprene as a Human Carcinogen. Risk Analysis 40:2, pages 294-318.
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