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Inhalation Toxicology
International Forum for Respiratory Research
Volume 11, 1999 - Issue 12
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Research Article

TWO-WEEK INHALATION TOXICITY OF POLYMERIC DIPHENYLMETHANE-4,4'-DIISOCYANATE (PMDI) IN RATS: Analysis of Biochemical and Morphological Markers of Early Pulmonary Response

Pages 1143-1163 | Published online: 01 Oct 2008

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Claudia Bolognesi, Xaver Baur, Boleslaw Marczynski, Hannu Norppa, Ovnair Sepai & Gabriele Sabbioni. (2001) Carcinogenic Risk of Toluene Diisocyanate and 4,4′-Methylenediphenyl Diisocyanate: Epidemiological and Experimental Evidence. Critical Reviews in Toxicology 31:6, pages 737-772.
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Articles from other publishers (18)

Wolfgang Dekant & Thomas Colnot. (2022) Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence. Toxicology and Industrial Health 38:9, pages 578-594.
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Pamella Fukuda de Castilho, Fabiana Gomes da Silva Dantas, Renata Pires de Araújo, Luis Henrique Almeida Castro, Flávio Henrique Souza de Araújo, Melyssa Negri, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Claudia Andrea Lima Cardoso, Silvia Aparecida Oesterreich & Kelly Mari Pires de Oliveira. (2021) General and genetic toxicology studies of Aleurites moluccana (L.) Willd. seeds in vitro and in vivo assays. Journal of Ethnopharmacology 280, pages 114478.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 52 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 45 .
Jürgen Pauluhn. (2011) Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology. Regulatory Toxicology and Pharmacology 61:3, pages 351-364.
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Peter SassMichaele JostenKirsten FamullaGuido Schiffer, Hans-Georg SahlLeendert Hamoen & Heike Brötz-Oesterhelt. (2011) Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proceedings of the National Academy of Sciences 108:42, pages 17474-17479.
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Hanna K. Lindberg, Anne Korpi, Tiina Santonen, Kirsi Säkkinen, Merja Järvelä, Jarkko Tornaeus, Niina Ahonen, Hilkka Järventaus, Anna-Liisa Pasanen, Christina Rosenberg & Hannu Norppa. (2011) Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4′-methylenediphenyl diisocyanate (MDI). Mutation Research/Genetic Toxicology and Environmental Mutagenesis 723:1, pages 1-10.
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Ken-ichiro Inoue, Eiko Koike & Hirohisa Takano. (2010) Comprehensive analysis of elastase-induced pulmonary emphysema in mice: Effects of ambient existing particulate matters. International Immunopharmacology 10:11, pages 1380-1389.
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Ken-ichiro Inoue, Eiko Koike, Rie Yanagisawa & Hirohisa Takano. (2010) Extensive Analysis of Elastase-Induced Pulmonary Emphysema in Rats: ALP in the Lung, a New Biomarker for Disease Progression?. Journal of Clinical Biochemistry and Nutrition 46:2, pages 168-176.
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Jürgen Pauluhn. (2008) Brown Norway Rat Asthma Model of Diphenylmethane-4,4′-Diisocyanate (MDI): Analysis of the Elicitation Dose-Response Relationship. Toxicological Sciences 104:2, pages 320-331.
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Jürgen Pauluhn & Hans-Werner Vohr. (2006) Partial C-fiber ablation modulates diphenylmethane-4,4′-diisocyanate (MDI)-induced respiratory allergy in Brown Norway rats. Toxicology 228:2-3, pages 188-199.
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Dingena L. Valstar, Marcel A. Schijf, Frans P. Nijkamp, Gert Storm, Josje H.E. Arts, C. Frieke Kuper, Nanne Bloksma & Paul A.J. Henricks. (2006) Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma. Toxicology and Applied Pharmacology 211:1, pages 20-29.
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Jürgen Pauluhn. (2005) Inhaled cationic amphiphilic drug-induced pulmonary phospholipidosis in rats and dogs: time-course and dose–response of biomarkers of exposure and effect. Toxicology 207:1, pages 59-72.
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Jürgen Pauluhn. (2004) Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage. Journal of Applied Toxicology 24:3, pages 247-17.
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Josje H.E Arts, Nanne Bloksma, Thea Leusink-Muis & C.Frieke Kuper. (2003) Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats. Toxicology and Applied Pharmacology 187:1, pages 38-49.
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Joanne D. Kilgour, Nicola J. Rattray, John Foster, Anthony Soames & Paul M. Hext. (2002) Pulmonary responses and recovery following single and repeated inhalation exposure of rats to polymeric methylene diphenyl diisocyanate aerosols. Journal of Applied Toxicology 22:6, pages 371-385.
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Jürgen Pauluhn & Jürgen Lewalter. (2002) Analysis of markers of exposure to polymeric methylene-diphenyl diisocyanate (pMDI) in rats: a comparison of dermal and inhalation routes of exposure. Experimental and Toxicologic Pathology 54:2, pages 135-146.
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Jurgen Pauluhn & Ulrich Mohr. (2016) Review Article: Inhalation Studies in Laboratory Animals—Current Concepts and Alternatives. Toxicologic Pathology 28:5, pages 734-753.
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