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Research Article

Progesterone-loaded nanosized transethosomes for vaginal permeation enhancement: formulation, statistical optimization, and clinical evaluation in anovulatory polycystic ovary syndrome

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Pages 183-194 | Received 12 Jun 2018, Accepted 11 Sep 2018, Published online: 13 Nov 2018

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Read on this site (6)

Minahal Munir, Muhammad Zaman, Muhammad Ahsan Waqar, Huma Hameed & Tehseen Riaz. (2023) A comprehensive review on transethosomes as a novel vesicular approach for drug delivery through transdermal route. Journal of Liposome Research 0:0, pages 1-16.
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Mohammed H. Elkomy, Shahira F. El Menshawe, Rasha M. Kharshoum, Amany M. Abdeltwab, Raghda R. S. Hussein, Doaa S. Hamad, Izzeddin Alsalahat & Heba M. Aboud. (2022) Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation. Drug Delivery 29:1, pages 2058-2071.
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Dhruv Sanjanwala, Vaishali Londhe, Rashmi Trivedi, Smita Bonde, Sujata Sawarkar, Vinita Kale & Vandana Patravale. (2022) Polysaccharide-based hydrogels for drug delivery and wound management: a review. Expert Opinion on Drug Delivery 19:12, pages 1664-1695.
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Rofida Albash, Menna M Abdellatif, Mariam Hassan & Noha M Badawi. (2021) Tailoring Terpesomes and Leciplex for the Effective Ocular Conveyance of Moxifloxacin Hydrochloride (Comparative Assessment): In-vitro, Ex-vivo, and In-vivo Evaluation. International Journal of Nanomedicine 16, pages 5247-5263.
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Heba F Salem, Rasha M Kharshoum, Sara M Awad, Mai Ahmed Mostafa & Heba A Abou-Taleb. (2021) Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study. International Journal of Nanomedicine 16, pages 4251-4276.
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Heba Farouk Salem, Mohamed Mahmoud Nafady, Rasha Mostafa Kharshoum, Omnia Ahmed Abd el-Ghafar & Hanan Osman Farouk. (2020) Mitigation of Rheumatic Arthritis in a Rat Model via Transdermal Delivery of Dapoxetine HCl Amalgamated as a Nanoplatform: In vitro and in vivo Assessment. International Journal of Nanomedicine 15, pages 1517-1535.
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Articles from other publishers (25)

Pavani Chowdary, Ananya Padmakumar & Aravind Kumar Rengan. (2023) Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review. MedComm – Biomaterials and Applications 2:4.
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Ramesh Joga, Bharathi Kannan, Sravani Yerram, Amruta Nandagawale, Manasi Gawai, Hitesh Kumar Behera, Neeraj Kumar, Parul GroverSaurabh Srivastava, Gorav MongaSandeep Kumar. (2023) Transethosome as a versatile nano vehicle for various indications and its regulatory insights . Pharmaceutical Development and Technology, pages 1-49.
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Zahra Saeidi, Rashin GitiMehdi RostamiFarhad Mohammadi. (2023) Nanotechnology-Based Drug Delivery Systems in the Transdermal Treatment of Melanoma. Advanced Pharmaceutical Bulletin 13:4, pages 646-662.
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Alan Raj, Kamal Dua, Rajesh Sreedharan Nair, C. Sarath Chandran & Angel Treasa Alex. (2023) Transethosome: An ultra-deformable ethanolic vesicle for enhanced transdermal drug delivery. Chemistry and Physics of Lipids 255, pages 105315.
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Nikhil Patil, Ronak Maheshwari & Sarika Wairkar. (2023) Advances in progesterone delivery systems: Still work in progress?. International Journal of Pharmaceutics 643, pages 123250.
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Shikha Mahant, Abhishek Kumar Sharma, Himanshu Gandhi, Ridhima Wadhwa, Kamal Dua & Deepak N. Kapoor. (2023) Emerging Trends and Potential Prospects in Vaginal Drug Delivery. Current Drug Delivery 20:6, pages 730-751.
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Amna Khalid, Hafiz Shoaib Sarwar, Muhammad Sarfraz, Muhammad Farhan Sohail, Aamir Jalil, Yousef A. Bin Jardan, Rabia Arshad, Ifrah Tahir & Zulcaif Ahmad. (2023) Formulation and characterization of thiolated chitosan/polyvinyl acetate based microneedle patch for transdermal delivery of dydrogesterone. Saudi Pharmaceutical Journal 31:5, pages 669-677.
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Ali M. Nasr, Noha M. Badawi, Yasmine H. Tartor, Nader M. Sobhy & Shady A. Swidan. (2023) Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity. Antibiotics 12:4, pages 707.
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Mohammad Adnan, Md. Faheem Haider, Nazish Naseem & Tanweer Haider. (2023) Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery. Drug Research 73:04, pages 200-212.
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Vikash Chaturvedi, Disha Sharma, Vaishnavi Pandey, Sudhanshu Mishra, Shobhit Prakash Shrivastava, Akanksha Sharma & Rishabha Malviya. (2023) Polycystic Ovarian Syndrome: Current Situation of Female Hormonal Disorder. Current Women s Health Reviews 19:2.
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Mohammad Javad Javid-Naderi, Ali Mahmoudi, Prashant Kesharwani, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2023) Recent advances of nanotechnology in the treatment and diagnosis of polycystic ovary syndrome. Journal of Drug Delivery Science and Technology 79, pages 104014.
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Ahmed A. H. Abdellatif, Basmah Nasser Aldosari, Amal Al-Subaiyel, Aisha Alhaddad, Waad A. Samman, Nermin E. Eleraky, Marwa G. Elnaggar, Hassan Barakat & Hesham M. Tawfeek. (2022) Transethosomal Gel for the Topical Delivery of Celecoxib: Formulation and Estimation of Skin Cancer Progression. Pharmaceutics 15:1, pages 22.
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Ayat A. Allam, Dina Fathalla, Mohamed A. Safwat & Ghareb M. Soliman. (2022) Transferosomes versus transethosomes for the dermal delivery for minoxidil: Preparation and in vitro/ex vivo appraisal. Journal of Drug Delivery Science and Technology 76, pages 103790.
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Jawad Ali, Reesha Raza, Sibgha Ameen, Anam Arshad, Fauzia Karim, Muhammad Waseem Akram & Lubna Shakir. (2022) Transethosomes: A Breakthrough System for Transdermal and Topical Drug Delivery. Pakistan BioMedical Journal.
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Ibrahim A. Mousa, Taha M. Hammady, Shadeed Gad, Sawsan A. Zaitone, Mohamed El-Sherbiny & Ossama M. Sayed. (2022) Formulation and Characterization of Metformin-Loaded Ethosomes for Topical Application to Experimentally Induced Skin Cancer in Mice. Pharmaceuticals 15:6, pages 657.
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Bhavana Valamla, Pradip Thakor, Rashmi Phuse, Mayuri Dalvi, Pratik Kharat, Ankaj Kumar, Dilip Panwar, Shashi Bala Singh, Pastorin Giorgia & Neelesh Kumar Mehra. (2022) Engineering drug delivery systems to overcome the vaginal mucosal barrier: Current understanding and research agenda of mucoadhesive formulations of vaginal delivery. Journal of Drug Delivery Science and Technology 70, pages 103162.
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Mahmoud M. El-Sonbaty, Mohamed A. Akl, Khalid M. El-Say & Alaa A. Kassem. (2022) Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?. Journal of Drug Delivery Science and Technology 68, pages 103096.
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Gulnara Gaynanova, Leysan Vasileva, Ruslan Kashapov, Darya Kuznetsova, Rushana Kushnazarova, Anna Tyryshkina, Elmira Vasilieva, Konstantin Petrov, Lucia Zakharova & Oleg Sinyashin. (2021) Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability. Molecules 26:22, pages 6786.
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Heba F. Salem, Amr Gamal, Haitham Saeed & Alaa S. Tulbah. (2021) The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer. Pharmaceutics 13:10, pages 1633.
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José das Neves, Fernando Notario-Pérez & Bruno Sarmento. (2021) Women-specific routes of administration for drugs: A critical overview. Advanced Drug Delivery Reviews 176, pages 113865.
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Jianying Lu, Teng Guo, Yunlong Fan, Zhe Li, Zehui He, Shuo Yin & Nianping Feng. (2021) Recent Developments in the Principles, Modification and Application Prospects of Functionalized Ethosomes for Topical Delivery. Current Drug Delivery 18:5, pages 570-582.
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Rita N. Wadetwar & Pranita S. Kanojiya. 2021. Nanopharmaceutical Advanced Delivery Systems. Nanopharmaceutical Advanced Delivery Systems 357 377 .
A. Correia, C.P. Costa, V. Silva, R. Silva, J.M. Sousa Lobo & A.C. Silva. (2020) Pessaries containing nanostructured lipid carriers (NLC) for prolonged vaginal delivery of progesterone. European Journal of Pharmaceutical Sciences 153, pages 105475.
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Amr Gamal F, Ossama M. Sayed, Fatma I. Abo El-Ela, Rasha M. Kharshoum & Heba F. Salem. (2020) Treatment of Basal Cell Carcinoma Via Binary Ethosomes of Vismodegib: In Vitro and In Vivo Studies. AAPS PharmSciTech 21:2.
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Heba F. Salem, Shahira F. El-Menshawe, Rasha A. Khallaf & Yasmine K. Rabea. (2019) A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization. Drug Delivery and Translational Research 10:1, pages 227-240.
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