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Ocular Immunology and Inflammation Volume 26, 2018 - Issue 6
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Original Articles

Anakinra in the Treatment of Patients with Refractory Scleritis: A Pilot Study

C. BottinDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, FranceCorrespondence[email protected] bahram.bodaghi@aphp
, MD,
A. FelDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD,
N. ButelDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD,
F. DomontDepartment of Internal Medicine and Clinical Immunology, Pitie-Salpetriere Hospital, Paris, France;DHU Inflammation, Immunopathologie, Biotherapie, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD,
A. L. RemondDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD,
L. SaveyDepartment of Internal Medicine and Clinical Immunology, Pitie-Salpetriere Hospital, Paris, France;DHU Inflammation, Immunopathologie, Biotherapie, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD,
V. TouitouDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD, PhD,
J. F. AlexandraDepartment of Internal Medicine, Bichat Hospital, Paris, France
, MD,
P. LeHoangDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD, PhD,
P. CacoubDepartment of Internal Medicine and Clinical Immunology, Pitie-Salpetriere Hospital, Paris, France;DHU Inflammation, Immunopathologie, Biotherapie, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD, PhD,
B. BodaghiDepartment of Ophthalmology, Pitie-Salpetriere Hospital, Paris, France;Centre national de reference maladies oculaires inflammatoires rares, DHU vision et handicap, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD, PhD &
D. SaadounDepartment of Internal Medicine and Clinical Immunology, Pitie-Salpetriere Hospital, Paris, France;DHU Inflammation, Immunopathologie, Biotherapie, Universite Paris VI-Pierre et Marie Curie, Paris, France
, MD, PhD show all
Pages 915-920 | Received 15 Oct 2016, Accepted 22 Feb 2017, Published online: 24 May 2017

Citations (20)

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Mariya Doctor, Somasheila I. Murthy & Liza Rajasekhar. (2023) Tocilizumab in Recalcitrant Bilateral Scleritis in a Case of Relapsing Polychondritis: A 17-year Follow Up. Ocular Immunology and Inflammation 31:4, pages 870-873.
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Carla Gaggiano, Virginia Berlengiero, Antonio Vitale, Maria Tarsia, Salvatore Grosso, Gian Marco Tosi, Francesca Ricci, Jurgen Sota, Valeria Caggiano, Bruno Frediani, Luca Cantarini, Marco Cattalini & Claudia Fabiani. (2022) The Role of Biologic Agents in the Management of Pediatric-Onset Noninfectious Posterior Scleritis. Ocular Immunology and Inflammation 0:0, pages 1-7.
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Melis Kabaalioğlu Güner, Ankur Mehra & Wendy M. Smith. (2021) Novel strategies for the diagnosis and treatment of scleritis. Expert Review of Ophthalmology 16:6, pages 431-448.
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Daniel Clarke, Lauren Sartor, Vu Do, Nicholas Manolios, Sanjay Swaminathan & Chameen Samarawickrama. (2023) Biologics in peripheral ulcerative keratitis. Seminars in Arthritis and Rheumatism 63, pages 152269.
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L. Perray, L. Ungerer, T. Chazal, D. Monnet, A. Brézin & B. Terrier. (2023) Sclérite et épisclérite. La Revue de Médecine Interne 44:12, pages 646-655.
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Dennis D. Arnold, Ayla Yalamanoglu & Onur Boyman. (2022) Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders. Frontiers in Immunology 13.
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Ahmad Abdel-Aty, Akash Gupta, Lucian Del Priore & Ninani Kombo. (2022) Management of noninfectious scleritis. Therapeutic Advances in Ophthalmology 14, pages 251584142110708.
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S. ShivajiS. Shivaji. 2022. Human Ocular Microbiome. Human Ocular Microbiome 253 285 .
Jurgen Sota, Matteo-Maria Girolamo, Bruno Frediani, Gian Marco Tosi, Luca Cantarini & Claudia Fabiani. (2021) Biologic Therapies and Small Molecules for the Management of Non-Infectious Scleritis: A Narrative Review. Ophthalmology and Therapy 10:4, pages 777-813.
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Raul E. Ruiz-Lozano, Lucas A. Garza-Garza, Osvaldo Davila-Cavazos, C. Stephen Foster & Alejandro Rodriguez-Garcia. (2021) The clinical and pathogenic spectrum of surgically-induced scleral necrosis: A review. Survey of Ophthalmology 66:4, pages 594-611.
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Steven E. Wilson. (2021) Interleukin-1 and Transforming Growth Factor Beta: Commonly Opposing, but Sometimes Supporting, Master Regulators of the Corneal Wound Healing Response to Injury. Investigative Opthalmology & Visual Science 62:4, pages 8.
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Seung Kwon Choi, Youn A Choi, So Hee Kim, Jae Jung Lee, Ik Soo Byon, Ji Eun Lee & Sung Who Park. (2021) The Effect of an Intravitreal Dexamethasone Implant for Refractory Posterior Scleritis. Journal of the Korean Ophthalmological Society 62:3, pages 322-328.
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Silvia Stefania, Ripalta Colia, Rotondo Cinzia, Addolorata Corrado & Francesco Paolo Cantatore. (2021) Off-label use of anti-IL-1 drugs in rheumatic diseases. International Journal of Immunopathology and Pharmacology 35, pages 205873842110065.
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Vivian Aranez & Julian AmbrusJrJr. (2019) Immunologic Adverse Effects of Biologics for the Treatment of Atopy. Clinical Reviews in Allergy & Immunology 59:2, pages 220-230.
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D.P.C. Vergouwen, A. Rothova, J.C. Ten Berge, R.M. Verdijk, J.A.M. van Laar, J.R. Vingerling & M.W.J. Schreurs. (2020) Current insights in the pathogenesis of scleritis. Experimental Eye Research 197, pages 108078.
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Alana Nevares, Robert Raut, Bonita Libman & Rula Hajj-Ali. (2020) Noninfectious Autoimmune Scleritis: Recognition, Systemic Associations, and Therapy. Current Rheumatology Reports 22:4.
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J. Michelle Kahlenberg & Insoo Kang. (2020) Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases. Arthritis & Rheumatology 72:3, pages 386-395.
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Claudia Fabiani, Jurgen Sota, Maite Sainz-de-la-Maza, Laura Pelegrín, Giacomo Emmi, Giuseppe Lopalco, Florenzo Iannone, Lorenzo Vannozzi, Silvana Guerriero, Maria Chiara Gelmi, Donato Rigante, Gian Marco Tosi, José Hernández-Rodríguez & Luca Cantarini. (2020) New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy. Mediators of Inflammation 2020, pages 1-6.
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. (2018) Anakinra. Reactions Weekly 1717:1, pages 31-31.
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