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Ocular Immunology and Inflammation Volume 30, 2022 - Issue 4
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Original Articles

Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells

Hiroshi Tawarayamaa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan;b Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, JapanORCID Iconhttps://orcid.org/0000-0001-8696-6700View further author information
, PhDORCID Icon,
Noriyuki Suzukia Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, MD,
Maki Inoue-Yanagimachia Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, MD,
Noriko Himoria Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, MD, PhD,
Satoru Tsudaa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, MD, PhD,
Kota Satoa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan;c Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, PhD,
Tomoaki Idad Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, PhD,
Takaaki Akaiked Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, MD, PhD,
Hiroshi Kunikataa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan;b Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
, MD, PhD &
Toru Nakazawaa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan;b Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan;c Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Japan;e Collaborative Program of Ophthalmic Drug Discovery, Tohoku University Graduate School of Medicine, Sendai, Japan;f Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanCorrespondence[email protected]
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Pages 789-800 | Received 13 May 2020, Accepted 30 Sep 2020, Published online: 20 Nov 2020

Citations (6)

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Hui Song, Ying-hao Wang, Hai-yan Zhou & Kun-ming Cui. (2022) Sulforaphane alleviates LPS-induced inflammatory injury in ARPE-19 cells by repressing the PWRN2/NF-kB pathway. Immunopharmacology and Immunotoxicology 44:6, pages 868-876.
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Articles from other publishers (5)

Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi & Takaaki Akaike. (2023) Supersulfide biology and translational medicine for disease control. British Journal of Pharmacology.
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Stephen Lindahl & Ming Xian. (2023) Recent development of polysulfides: Chemistry and biological applications. Current Opinion in Chemical Biology 75, pages 102325.
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Hiroshi Tawarayama, Kota Umeki, Maki Inoue-Yanagimachi, Naoki Takahashi, Hirokazu Hasegawa, Noriko Himori, Satoru Tsuda, Hiroshi Kunikata, Takaaki Akaike & Toru Nakazawa. (2023) Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells. Scientific Reports 13:1.
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Hiroshi Tawarayama, Yoshiyuki Hirata, Keiko Uchida, Noriko Himori, Shinichi Uesato & Toru Nakazawa. (2023) Isozyme-specific histone deacetylase 1/2 inhibitor K560 attenuates oxidative stress-induced retinal cell death. Neuroscience Letters 793, pages 136978.
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Tomohiro SawaTsuyoshi Takata, Tetsuro MatsunagaHideshi Ihara, Hozumi Motohashi & Takaaki Akaike. (2022) Chemical Biology of Reactive Sulfur Species: Hydrolysis-Driven Equilibrium of Polysulfides as a Determinant of Physiological Functions. Antioxidants & Redox Signaling 36:4-6, pages 327-336.
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