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Research Article

Human herpes simplex virus keratitis: the pathogenesis revisited

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Pages 255-285 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Tomoko Orita, Kazuhiro Kimura, Teruo Nishida & Koh-Hei Sonoda. (2013) Cytokine and Chemokine Secretion Induced by Poly(I:C) through NF-κB and Phosphoinositide 3-Kinase Signaling Pathways in Human Corneal Fibroblasts. Current Eye Research 38:1, pages 53-59.
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Blair B Lonsberry. (2008) Is herpes simplex virus keratitis a different disease in children?. Clinical and Experimental Optometry 91:1, pages 115-119.
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David C Ritterband. (2006) Herpes simplex keratitis: classification, pathogenesis and therapy. Expert Review of Ophthalmology 1:2, pages 241-256.
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Articles from other publishers (51)

Nan Zhou, Deyuan Zheng, Qiao You, Taige Chen, Jiaxuan Jiang, Wenhao Shen, Di Zhang, Junpeng Liu, Deyan Chen & Kai Hu. (2023) Therapeutic Potential of Biochanin A in Herpes Simplex Keratitis. Pharmaceuticals 16:9, pages 1240.
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Elif Akbas Ulman, Ozlem Barut Selver, Elif Demirkilinc Biler & Melis Palamar. (2023) Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis. Cornea 42:9, pages 1099-1103.
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Hanna H. Schalkwijk, Robert Snoeck & Graciela Andrei. (2022) Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives. Biochemical Pharmacology 206, pages 115322.
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Bisant A. Labib & DeGaulle I. Chigbu. (2022) Clinical Management of Herpes Simplex Virus Keratitis. Diagnostics 12:10, pages 2368.
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Buyun Kim, Eun-Bin Kwon, Hye Jin Yang, Wei Li, Youn-Hwan Hwang, Young Soo Kim, Malk Eun Pak, Younghoon Go & Jang-Gi Choi. (2022) Vaccinium bracteatum Thunb Extract Inhibits HSV-1 Infection by Regulating ER Stress and Apoptosis. Antioxidants 11:9, pages 1773.
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Romina Mayra Lasagni Vitar, Filippo Bonelli, Paolo Rama & Giulio Ferrari. (2022) Immunity and pain in the eye: focus on the ocular surface. Clinical and Experimental Immunology 207:2, pages 149-163.
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Tae-im Kim, Dimitri T. Azar & Deborah Pavan-Langston. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 187 279 .
Raghuram Koganti, Tejabhiram Yadavalli, Raza Ali Naqvi, Deepak Shukla & Afsar R. Naqvi. (2021) Pathobiology and treatment of viral keratitis. Experimental Eye Research 205, pages 108483.
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Tae-im Kim, Dimitri T. Azar & Deborah Pavan-Langston. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 94 .
Giuseppe Giannaccare, Marco Pellegrini, Cristina Bovone, Rossella Spena, Carlotta Senni, Vincenzo Scorcia & Massimo Busin. (2020) Anti-VEGF Treatment in Corneal Diseases. Current Drug Targets 21:12, pages 1159-1180.
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Dimitri Roels, Liselotte Coorevits & Katrien Lagrou. (2020) Tintelnotia destructans as an emerging opportunistic pathogen: First case of T. destructans superinfection in herpetic keratitis. American Journal of Ophthalmology Case Reports 19, pages 100791.
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Jonas Eckermann, Jens Eduard Meyer & Thomas Guenzel. (2020) Etiology and therapy of delayed facial paralysis after middle ear surgery. European Archives of Oto-Rhino-Laryngology 277:4, pages 965-974.
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Raghuram Koganti, Tejabhiram Yadavalli & Deepak Shukla. (2019) Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. Microorganisms 7:10, pages 429.
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Poojabahen Tajpara, Michael Mildner, Ralf Schmidt, Martin Vierhapper, Johannes Matiasek, Theresia Popow-Kraupp, Christopher Schuster & Adelheid Elbe-Bürger. (2019) A Preclinical Model for Studying Herpes Simplex Virus Infection. Journal of Investigative Dermatology 139:3, pages 673-682.
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Ann-Marie Lobo, Alex M. Agelidis & Deepak Shukla. (2019) Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation. The Ocular Surface 17:1, pages 40-49.
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Josune Torrecilla, Ana del Pozo-Rodríguez, Mónica Vicente-Pascual, María Ángeles Solinís & Alicia Rodríguez-Gascón. (2018) Targeting corneal inflammation by gene therapy: Emerging strategies for keratitis. Experimental Eye Research 176, pages 130-140.
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Shaopin ZhuXun XuKun LiuQing GuFang WeiXiaolu Yang. (2018) PAPep Inhibits Secretion of Poly(I:C)-Induced Inflammatory Cytokines and ICAM-1 Expression in Corneal Fibroblasts by Suppressing the NF-κB/p38 Pathway. Journal of Ocular Pharmacology and Therapeutics 34:5, pages 395-402.
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Alex M. Agelidis, Satvik R. Hadigal, Dinesh Jaishankar & Deepak Shukla. (2017) Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Reports 20:2, pages 439-450.
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Shengtao Fan, Hongzhi Cai, Xingli Xu, Min Feng, Lichun Wang, Yun Liao, Ying Zhang, Zhanlong He, Fengmei Yang, Wenhai Yu, Jingjing Wang, Jumin Zhou & Qihan Li. (2017) The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features. Viruses 9:2, pages 26.
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Jayavardhana R. Palem, Mudit Mudit, Shao-chung V. Hsia & Khalid A. El Sayed. (2017) Discovery and preliminary structure-activity relationship of the marine natural product manzamines as herpes simplex virus type-1 inhibitors. Zeitschrift für Naturforschung C 72:1-2, pages 49-54.
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Uday K Bhatt, MN Abdul Karim, Jeremy I Prydal, Senthil V Maharajan & Usama Fares. (2016) Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. Cochrane Database of Systematic Reviews 2016:11.
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Takashi Masaoka, Haiyan Zhao, Danielle R. Hirsch, Michael P. D’Erasmo, Christine Meck, Brittany Varnado, Ankit Gupta, Marvin J. Meyers, Joel Baines, John A. Beutler, Ryan P. Murelli, Liang Tang & Stuart F. J. Le Grice. (2016) Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors. Biochemistry 55:5, pages 809-819.
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Adalbert Krawczyk, Miriam Dirks, Maren Kasper, Anna Buch, Ulf Dittmer, Bernd Giebel, Lena Wildschütz, Martin Busch, Andre Goergens, Karl E. Schneweis, Anna M. Eis-Hübinger, Beate Sodeik, Arnd Heiligenhaus, Michael Roggendorf & Dirk Bauer. (2015) Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody. PLOS ONE 10:1, pages e0116800.
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Rebecca M. Harman, Leen Bussche, Eric C. Ledbetter & Gerlinde R. Van de Walle. (2014) Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis. Journal of Virology 88:23, pages 13669-13677.
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A. Mendy. (2014) Herpes Simplex Virus Type 1 and Cognition in Different Stages of Life. Journal of Infectious Diseases 210:2, pages 332-333.
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C. Spira, N. Szentmáry, A. Hasenfus, M. Sauter, S. Smola & B. Seitz. (2013) Therapierefraktäre stromale Herpeskeratitis unter AciclovirTherapy refractory stromal Herpes keratitis under aciclovir. Der Ophthalmologe 111:7, pages 654-659.
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Hui-Wen Yao, Pin-Hung Lin, Fang-Hsiu Shen, Guey-Chuen Perng, Yuk-Ying Tung, Sheng-Min Hsu & Shun-Hua Chen. (2014) Tranylcypromine Reduces Herpes Simplex Virus 1 Infection in Mice. Antimicrobial Agents and Chemotherapy 58:5, pages 2807-2815.
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Jacek Rolinski & Iwona Hus. (2014) Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis. Journal of Immunology Research 2014, pages 1-9.
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Monique van Velzen, David A. M. C. van de Vijver, Freek B. van Loenen, Albert D. M. E. Osterhaus, Lies Remeijer & Georges M. G. M. Verjans. (2013) Acyclovir Prophylaxis Predisposes to Antiviral-Resistant Recurrent Herpetic Keratitis. The Journal of Infectious Diseases 208:9, pages 1359-1365.
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Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Ravinder Earla, Suman Sirimulla, Jake Brain Bailey, Dhananjay Pal & Ashim K. Mitra. (2013) Novel Biotinylated Lipid Prodrugs of Acyclovir for the Treatment of Herpetic Keratitis (HK): Transporter Recognition, Tissue Stability and Antiviral Activity. Pharmaceutical Research 30:8, pages 2063-2076.
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Adalbert Krawczyk, Michaela A. E. Arndt, Ludger Grosse-HovestWilko WeichertBernd GiebelUlf DittmerHartmut Hengel, Dirk Jäger, Karl E. Schneweis, Anna M. Eis-Hübinger, Michael RoggendorfJürgen Krauss. (2013) Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody. Proceedings of the National Academy of Sciences 110:17, pages 6760-6765.
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Anusha Harishankar, Malathi Jambulingam, Raajaram Gowrishankar, Annapoorni Venkatachalam, Umashankar Vetrivel, Sathyabaarathi Ravichandran, Samson Moses Yesupadam & Hajib Narahari Rao Madhavan. (2012) Phylogenetic comparison of exonic US4, US7 and UL44 regions of clinical herpes simplex virus type 1 isolates showed lack of association between their anatomic sites of infection and genotypic/sub genotypic classification. Virology Journal 9:1.
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E. Stavridis, Z. Gatzioufas, A. Hasenfus, M. Sauter, S. Smola & B. Seitz. (2012) Ping-Pong-Transmission von Herpes-simplex-Virus 1 nach HornhauttransplantationPing-pong transmission of herpes simplex virus 1 following corneal transplantation. Der Ophthalmologe 109:10, pages 1017-1021.
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Hui-Wen Yao, Shih-Heng Chen, Ching Li, Yuk-Ying Tung & Shun-Hua Chen. (2012) Suppression of Transcription Factor Early Growth Response 1 Reduces Herpes Simplex Virus 1-Induced Corneal Disease in Mice. Journal of Virology 86:16, pages 8559-8567.
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Toine Hillenaar, Hugo van Cleynenbreugel, Georges M.G.M. Verjans, René J. Wubbels & Lies Remeijer. (2012) Monitoring the Inflammatory Process in Herpetic Stromal Keratitis: The Role of In Vivo Confocal Microscopy. Ophthalmology 119:6, pages 1102-1110.
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Lichen Jing, Jürgen Haas, Tiana M. Chong, Joseph J. Bruckner, Greg C. Dann, Lichun Dong, Joshua O. Marshak, Christopher L. McClurkan, Tori N. Yamamoto, Susanne M. Bailer, Kerry J. Laing, Anna Wald, Georges M.G.M. Verjans & David M. Koelle. (2012) Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine. Journal of Clinical Investigation 122:2, pages 654-673.
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Hossein Mostafa Elbadawy, Marine Gailledrat, Carole Desseaux, Diego Ponzin & Stefano Ferrari. (2012) Targeting Herpetic Keratitis by Gene Therapy. Journal of Ophthalmology 2012, pages 1-14.
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B. Seitz & A. Heiligenhaus. (2011) „Herpeskeratitis““Herpetic keratitis”. Der Ophthalmologe 108:4, pages 385-398.
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Wayne Heaselgrave, James Lonnen, Simon Kilvington, Jacinto Santodomingo-Rubido & Osamu Mori. (2010) The Disinfection Efficacy of MeniCare Soft Multipurpose Solution Against Acanthamoeba and Viruses Using Stand-Alone Biocidal and Regimen Testing. Eye & Contact Lens: Science & Clinical Practice 36:2, pages 90-95.
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Peter Norberg. (2010) Divergence and genotyping of human α-herpesviruses: An overview. Infection, Genetics and Evolution 10:1, pages 14-25.
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Lee S. Engel, Charles V. Sanders & Fred A. Lopez. 2009. Infectious Diseases in Critical Care Medicine. Infectious Diseases in Critical Care Medicine 19 48 .
Mario Saravia, Gustavo Zapata, Paula Ferraiolo, Lourdes Racca & Alejandro Berra. (2009) Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis. Graefe's Archive for Clinical and Experimental Ophthalmology 247:10, pages 1409-1416.
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Uday K Bhatt, MN Abdul Karim & Jeremy I Prydal. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Eric C. Ledbetter, Edward J. Dubovi, Sung G. Kim, David J. Maggs & Rodrigo C. Bicalho. (2009) Experimental primary ocular canine herpesvirus-1 infection in adult dogs. American Journal of Veterinary Research 70:4, pages 513-521.
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Rui Duan, Rory D. de Vries, Albert D. M. E. Osterhaus, Lies Remeijer & Georges M. G. M. Verjans. (2008) Acyclovir‐Resistant Corneal HSV‐1 Isolates from Patients with Herpetic Keratitis. The Journal of Infectious Diseases 198:5, pages 659-663.
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María Alejandra Carrasco. (2008) Subconjunctival Bevacizumab for Corneal Neovascularization in Herpetic Stromal Keratitis. Cornea 27:6, pages 743-745.
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Deborah Pavan-Langston. 2008. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology 637 704 .
Eytan A. Klausner, Dan Peer, Robert L. Chapman, Richard F. Multack & Shridhar V. Andurkar. (2007) Corneal gene therapy. Journal of Controlled Release 124:3, pages 107-133.
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Alessandro Lambiase, Marco Coassin, Nicola Costa, Paolo Lauretti, Alessandra Micera, Emiliano Ghinelli, Luigi Aloe, Paolo Rama & Stefano Bonini. (2007) Topical treatment with nerve growth factor in an animal model of herpetic keratitis. Graefe's Archive for Clinical and Experimental Ophthalmology 246:1, pages 121-127.
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Peter Norberg, Tomas Bergström & Jan-Åke Liljeqvist. (2006) Genotyping of Clinical Herpes Simplex Virus Type 1 Isolates by Use of Restriction Enzymes. Journal of Clinical Microbiology 44:12, pages 4511-4514.
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Soumyajit MajumdarYasser E. NashedKunal PatelRitesh JainMotoki ItahashiDonna M. NeumannJames M. HillAshim K. Mitra. (2005) Dipeptide Monoester Ganciclovir Prodrugs for Treating HSV-1-Induced Corneal Epithelial and Stromal Keratitis: In Vitro and In Vivo Evaluations . Journal of Ocular Pharmacology and Therapeutics 21:6, pages 463-474.
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