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PCOS and Carnitine

RETRACTED ARTICLE: Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

Pages 442-447 | Received 01 Nov 2016, Accepted 30 Jan 2017, Published online: 21 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Jihan Nurul Thurfah, Christine, Petrus Putra Bagaskhara, Sofa Dewi Alfian & Irma Melyani Puspitasari. (2022) Dietary Supplementations and Depression. Journal of Multidisciplinary Healthcare 15, pages 1121-1141.
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Xiangyi Cheng & Bing He. (2022) Clinical and Biochemical Potential of Antioxidants in Treating Polycystic Ovary Syndrome. International Journal of Women's Health 14, pages 467-479.
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Dan Liao, Xiaomei Liu, Xiuying Yuan, Poling Feng, Zhiwei Ouyang, Yanyan Liu & Cuifen Li. (2022) Clinical evidence of the effects of carnitine supplementation on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a systematic review and meta-analysis. Gynecological Endocrinology 38:2, pages 110-115.
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Bing Cao, Dongfang Wang, Zihang Pan, Roger S. McIntyre, Elisa Brietzke, Mehala Subramanieapillai, Yasaman Nozari & Jingyu Wang. (2020) Metabolic profiling for water-soluble metabolites in patients with schizophrenia and healthy controls in a Chinese population: A case-control study. The World Journal of Biological Psychiatry 21:5, pages 357-367.
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Ibrahim El Sharkwy & Mostafa Sharaf El-Din. (2019) l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Gynecological Endocrinology 35:8, pages 701-705.
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Vahid Maleki, Hamed Jafari-Vayghan, Arvin Kashani, Fardin Moradi, Mahdi Vajdi, Sorayya Kheirouri & Mohammad Alizadeh. (2019) Potential roles of carnitine in patients with polycystic ovary syndrome: a systematic review. Gynecological Endocrinology 35:6, pages 463-469.
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Mehri Jamilian, Fatemeh Foroozanfard, Elham Kavossian, Esmat Aghadavod, Elaheh Amirani, Mostafa Mahdavinia, Alireza Mafi & Zatollah Asemi. (2019) Carnitine and chromium co-supplementation affects mental health, hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome. Journal of Psychosomatic Obstetrics & Gynecology 0:0, pages 1-9.
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Feng Wang, Rui-Ying Yuan, Li Li, Tie-Gang Meng, Li-Hua Fan, Ying Jing, Ren-Ren Zhang, Yuna-Yuan Li, Qiu-Xia Liang, Feng Dong, Yi Hou, Heide Schatten, Qing-Yuan Sun & Xiang-Hong Ou. (2018) Mitochondrial regulation of [Ca2+]i oscillations during cell cycle resumption of the second meiosis of oocyte. Cell Cycle 17:12, pages 1471-1486.
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Junhui He, Renhe Deng, Yanhong Wei, Shun Zhang, Mingxuan Su, Masong Tang, Jinyuan Wang, Weihua Nong & Xiaocan Lei. (2024) Efficacy of antioxidant supplementation in improving endocrine, hormonal, inflammatory, and metabolic statuses of PCOS: a meta-analysis and systematic review. Food & Function 15:4, pages 1779-1802.
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Sidra Malik, Saira Saeed, Ammara Saleem, Muhammad Imran Khan, Aslam Khan & Muhammad Furqan Akhtar. (2024) Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs. Frontiers in Endocrinology 14.
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Xinyin Hu, Wanyi Wang, Xuhan Su, Haoye Peng, Zuolin Tan, Yunqing Li & Yuhua Huang. (2023) Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis. PeerJ 11, pages e16410.
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Samira Rastgoo, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Niloufar Rasaei, Yasaman Aali, Mohammad Zamani, Farideh Shiraseb & Omid Asbaghi. (2023) The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose–response meta-analysis. Inflammopharmacology 31:5, pages 2173-2199.
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Yi Gong, Tong Jiang, Hui He, Yu Wang, Guo‐Lin Wu, Ying Shi, Qinjun Cai, Can‐Li Xiong, Rong Shen & Jian Li. (2023) Effects of carnitine on glucose and lipid metabolic profiles and fertility outcomes in women with polycystic ovary syndrome: A systematic review and meta‐analysis. Clinical Endocrinology 98:5, pages 682-691.
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Yanfei Li, Yuchen Xie, Chensheng Qiu, Bowen Yu, Fangzheng Yang, Yuanchao Cheng, Weizhen Zhong & Junhua Yuan. (2023) Effects of l -carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis . Food & Function 14:5, pages 2502-2517.
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Stephanie Cowan, Siew Lim, Chelsea Alycia, Stephanie Pirotta, Rebecca Thomson, Melanie Gibson-Helm, Rebecca Blackmore, Negar Naderpoor, Christie Bennett, Carolyn Ee, Vibhuti Rao, Aya Mousa, Simon Alesi & Lisa Moran. (2023) Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity. BMC Endocrine Disorders 23:1.
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Zina Abdullah Hussein, Wassan Nori & Khulood H. Oudah. L-carnitine role in fertility and health. L-carnitine role in fertility and health.
Mohd Falihin Mohd Shukri, Mohd Noor Norhayati, Salziyan Badrin & Azidah Abdul Kadir. (2022) Effects of L-carnitine supplementation for women with polycystic ovary syndrome: a systematic review and meta-analysis. PeerJ 10, pages e13992.
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Dong-Dong Wang, Ya-Feng Li, Yi-Zhen Mao, Su-Mei He, Ping Zhu & Qun-Li Wei. (2022) A machine-learning approach for predicting the effect of carnitine supplementation on body weight in patients with polycystic ovary syndrome. Frontiers in Nutrition 9.
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Simon Alesi, Carolyn Ee, Lisa J Moran, Vibhuti Rao & Aya Mousa. (2022) Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome. Advances in Nutrition 13:4, pages 1243-1266.
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Ting Liu, Kunhong Deng, Ying Xue, Rui Yang, Rong Yang, Zhicheng Gong & Mimi Tang. (2022) Carnitine and Depression. Frontiers in Nutrition 9.
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Giovanni Pagano, Federico V. Pallardó, Alex Lyakhovich, Luca Tiano & Marco Trifuoggi. (2021) Mitigating the pro-oxidant state and melanogenesis of Retinitis pigmentosa: by counteracting mitochondrial dysfunction. Cellular and Molecular Life Sciences 78:23, pages 7491-7503.
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Roghaye Gharaei, Forough Mahdavinezhad, Esmaeil Samadian, Jahanbakhsh Asadi, Zhaleh Ashrafnezhad, Ladan Kashani & Fardin Amidi. (2021) Antioxidant supplementations ameliorate PCOS complications: a review of RCTs and insights into the underlying mechanisms. Journal of Assisted Reproduction and Genetics 38:11, pages 2817-2831.
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Tabatha Petrillo, Christian Battipaglia, Mohamed Ashraf Virmani, Andrea R. Genazzani & Alessandro D. Genazzani. (2021) Neuroendocrine Effects of Carnitines on Reproductive Impairments. International Journal of Molecular Sciences 22:19, pages 10781.
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Pallavi Dubey, Sireesha Reddy, Sarah Boyd, Christina Bracamontes, Sheralyn Sanchez, Munmun Chattopadhyay & Alok Dwivedi. (2021) Effect of Nutritional Supplementation on Oxidative Stress and Hormonal and Lipid Profiles in PCOS-Affected Females. Nutrients 13:9, pages 2938.
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Na Li & Hui Zhao. (2021) Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update. Frontiers in Medicine 8.
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Simon Alesi, Drishti Ghelani & Aya Mousa. (2021) Metabolomic Biomarkers in Polycystic Ovary Syndrome: A Review of the Evidence. Seminars in Reproductive Medicine 39:03/04, pages 102-110.
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Saman Tauqir, Momina Israr, Bushra Rauf, Muhammad Omar Malik, Syed Hamid Habib, Fawad Ali Shah, Muhammad Usman, Muhammad Asif Raza, Inayat Shah, Haroon Badshah, Ehtesham Ehtesham & Mohsin Shah. (2021) Acetyl-l-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial. Advances in Therapy 38:7, pages 3842-3856.
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Antoine Aoun, Veronique El Khoury & Roubina Malakieh. (2021) Can Nutrition Help in the Treatment of Infertility?. Preventive Nutrition and Food Science 26:2, pages 109-120.
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Jitender Kumar Bhardwaj, Harish Panchal & Priyanka Saraf. (2020) Ameliorating Effects of Natural Antioxidant Compounds on Female Infertility: a Review. Reproductive Sciences 28:5, pages 1227-1256.
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Nasir Talenezhad, Masoud Rahmanian, Farhang Mirzavandi, Mahdieh Hosseinzadeh, Hossein Fallahzadeh, Javad Zavar Reza & Hassan Mozaffari-Khosravi. (2020) Effects of L-carnitine supplementation on oxidative and metabolic status in patients with type 2 diabetes mellitus: A randomized, double-blind, clinical trial. European Journal of Integrative Medicine 40, pages 101243.
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Hadis Fathizadeh, Alireza Milajerdi, Željko Reiner, Elaheh Amirani, Zatollah Asemi, Mohammad Ali Mansournia & Jamal Hallajzadeh. (2020) The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes & Metabolic Disorders 19:2, pages 1879-1894.
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Gaoping CuiYing QingXiaowen HuPengkun WangLiya SunXuhan YangJie JiangJuan ZhangHang WangLei FengYuhua ShenShengying QinChunling Wan. (2020) Serum Metabolomic Profiling Based on Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry: Do the Dysfunctions of Metabolic Pathways Reveal a Universal Risk of Oxidative Stress in Schizophrenia?. Antioxidants & Redox Signaling 33:10, pages 679-688.
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Giovanna Di Emidio, Francesco Rea, Martina Placidi, Giulia Rossi, Domenica Cocciolone, Ashraf Virmani, Guido Macchiarelli, Maria Grazia Palmerini, Anna Maria D’Alessandro, Paolo Giovanni Artini & Carla Tatone. (2020) Regulatory Functions of L-Carnitine, Acetyl, and Propionyl L-Carnitine in a PCOS Mouse Model: Focus on Antioxidant/Antiglycative Molecular Pathways in the Ovarian Microenvironment. Antioxidants 9:9, pages 867.
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Moein Askarpour, Amir Hadi, Maryam Miraghajani, Michael E. Symonds, Ali Sheikhi & Ehsan Ghaedi. (2020) Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Pharmacological Research 151, pages 104554.
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Maryam Asadi, Mehran Rahimlou, Farideh Shishehbor & Anahita Mansoori. (2020) The effect of l-carnitine supplementation on lipid profile and glycaemic control in adults with cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials. Clinical Nutrition 39:1, pages 110-122.
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Philip D. Chilibeck, Maryam Kazemi, Laura E. McBreairty & Gordon A. Zello. 2020. Obesity and Diabetes. Obesity and Diabetes 907 920 .
Ibrahim A. El Sharkwy & Walled M. Abd El Aziz. (2019) Retracted: Randomized controlled trial of N ‐acetylcysteine versus l ‐carnitine among women with clomiphene‐citrate‐resistant polycystic ovary syndrome . International Journal of Gynecology & Obstetrics 147:1, pages 59-64.
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Bing Cao, Dongfang Wang, Zihang Pan, Elisa Brietzke, Roger S. McIntyre, Natalie Musial, Rodrigo B. Mansur, Mehala Subramanieapillai, Jing Zeng, Ninghua Huang & Jingyu Wang. (2019) Characterizing acyl-carnitine biosignatures for schizophrenia: a longitudinal pre- and post-treatment study. Translational Psychiatry 9:1.
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Ashok Agarwal, Pallav Sengupta & Damayanthi Durairajanayagam. (2018) Role of L-carnitine in female infertility. Reproductive Biology and Endocrinology 16:1.
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