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Gynecological Endocrinology Volume 35, 2019 - Issue 7
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DOES DOUBLE TRIGGER (GNRH AGONIST+ HCG) IMPROVE OUTCOME IN POOR RESPONDERS?

Does double trigger (GnRH-agonist + hCG) improve outcome in poor responders undergoing IVF-ET cycle? A pilot study

Jigal HaasDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Eran ZilberbergDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Ravit NahumDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Aya Mor SasonDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Ariel HourvitzDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Itai GatDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
&
Raoul OrvietoDepartment of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; ;The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, IsraelCorrespondence[email protected]
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Pages 628-630 | Received 19 Nov 2018, Accepted 23 Dec 2018, Published online: 27 Feb 2019

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Firat Tulek, Alper Kahraman & Lutfi Cem Demirel. (2022) Dual trigger with gonadotropin releasing hormone agonist and human chorionic gonadotropin improves live birth rates in POSEIDON group 3 and 4 expected poor responders. Gynecological Endocrinology 38:9, pages 731-735.
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Ilknur Mutlu, Erhan Demirdag, Funda Cevher, Ahmet Erdem & Mehmet Erdem. (2022) Dual trigger with the combination of gonadotropin-releasing hormone agonist and standard dose of human chorionic gonadotropin improves in vitro fertilisation outcomes in poor ovarian responders. Journal of Obstetrics and Gynaecology 42:5, pages 1239-1244.
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Articles from other publishers (22)

Raoul Orvieto. 2024. Handbook of Current and Novel Protocols for the Treatment of Infertility. Handbook of Current and Novel Protocols for the Treatment of Infertility 189 196 .
Müge Keskin, Tolga Ecemiş, Ahmet Atik, Pelin Yeğen, Ece Kalkan & Gamze Sinem Yücel. (2023) Cycle outcomes of dual trigger (GnRH agonist+hCG) versus human chorionic gonadotropin trigger alone in POSEDION group 3–4 poor-responders and normo-responders: A prospective randomized study. Journal of Gynecology Obstetrics and Human Reproduction 52:8, pages 102633.
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Fang-Fang He, Wenhui Hu, Lin Yong & Yu-Mei Li. (2023) Triggering of ovulation for GnRH-antagonist cycles in normal and low ovarian responders undergoing IVF/ICSI: A systematic review and meta-analysis of randomized trials. European Journal of Obstetrics & Gynecology and Reproductive Biology 289, pages 65-73.
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Munire Funda Cevher Akdulum, Seçil İrem Arık, Erhan Demirdağ, Mehmet Erdem & Ahmet Erdem. (2023) In Vitro Fertilization Outcomes With a Dual Trigger in Normoresponders in Antagonist Cycles. Cureus.
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Li-Hsin Hsia, Tsung-Hsien Lee, Yu-Hsuan Lin, Yun-Yao Huang, Hao-Jung Chang & Yung-Liang Liu. (2023) Dual trigger improves the pregnancy rate in fresh in vitro fertilization (IVF) cycles compared with the human chorionic gonadotropin (hCG) trigger: a systematic review and meta-analysis of randomized trials. Journal of Assisted Reproduction and Genetics 40:9, pages 2063-2077.
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Cari Nicholas, Sarah Darmon, Pasquale Patrizio, David F. Albertini, David H. Barad & Norbert Gleicher. (2023) Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF. iScience 26:8, pages 107308.
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Raoul Orvieto. (2023) Stop GnRH-agonist/GnRH-antagonist protocol: a different insight on ovarian stimulation for IVF. Reproductive Biology and Endocrinology 21:1.
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C. Tibi. 2023. Infertilité. Infertilité 153 163 .
Yuval Yung, Adva Aizer, Sarah Tieb, Sharon Avhar Maydan, Ettie Maman, Lilach Marom Haham, Jigal Haas & Raoul Orvieto. (2022) The in-vitro effect of gonadotropins’ type and combination on Granulosa cells gene expressions. Reproductive Biology and Endocrinology 20:1.
Crossref
Raoul Orvieto. (2022) Pretreatment: Does it improve quantity or quality?. Fertility and Sterility 117:4, pages 657-663.
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Lan N. Vuong. (2022) Alteration of final maturation and laboratory techniques in low responders. Fertility and Sterility 117:4, pages 675-681.
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Meng-Han Yan, Jing-Xian Cao, Jin-Wei Hou, Wen-Jing Jiang, Dan-Dan Wang, Zhen-Gao Sun & Jing-Yan Song. (2022) GnRH Agonist and hCG (Dual Trigger) Versus hCG Trigger for Final Oocyte Maturation in Expected Normal Responders With a High Immature Oocyte Rate: Study Protocol for a Randomized, Superiority, Parallel Group, Controlled Trial. Frontiers in Endocrinology 13.
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Deepti Gupta, Akanksha Sood & Raj Mathur. (2022) GnRH agonist trigger in modern reproductive medicine practice − when, why, and how?. Fertility Science and Research 9:2, pages 80.
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Kai-Lun Hu, Siwen Wang, Xiaohang Ye, Dan Zhang & Sarah Hunt. (2021) GnRH agonist and hCG (dual trigger) versus hCG trigger for follicular maturation: a systematic review and meta-analysis of randomized trials. Reproductive Biology and Endocrinology 19:1.
Crossref
Yanru Hou, Li Tian, Huixin Liu, Jiajia Ai, Yanbin Wang & Huan Shen. (2021) The effect of serum luteinizing hormone on trigger day with a GnRH antagonist protocol in IVF/ICSI treatment. Gynecology and Obstetrics Clinical Medicine 1:4, pages 205-210.
Crossref
Mathilde Bourdon, Maëliss Peigné, Céline Solignac, Bernadette Darné, Solène Languille, Khaled Pocate-Cheriet & Pietro Santulli. (2021) Gonadotropin-releasing hormone agonist (alone or combined with human chorionic gonadotropin) vs. human chorionic gonadotropin alone for ovulation triggering during controlled ovarian stimulation for in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. F&S Reviews 2:4, pages 353-370.
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Ahmed M. Maged, Mohamed A. Ragab, Amal Shohayeb, Waleed Saber, Sherif Ekladious, Eman A. Hussein, Akmal El‐Mazny & Ayman Hany. (2020) Comparative study between single versus dual trigger for poor responders in GnRH‐antagonist ICSI cycles: A randomized controlled study. International Journal of Gynecology & Obstetrics 152:3, pages 395-400.
Crossref
Mehtap Polat, Sezcan Mumusoglu, Irem Yarali Ozbek, Gurkan Bozdag & Hakan Yarali. (2021) Double or dual stimulation in poor ovarian responders: where do we stand?. Therapeutic Advances in Reproductive Health 15, pages 263349412110241.
Crossref
J Haas, R Bassil, N Samara, E Zilberberg, C Mehta, R Orvieto & R F Casper. (2020) GnRH agonist and hCG (dual trigger) versus hCG trigger for final follicular maturation: a double-blinded, randomized controlled study. Human Reproduction 35:7, pages 1648-1654.
Crossref
Raoul Orvieto, Michal Kirshenbaum, Valentina Galiano, Tal Elkan-Miller, Eran Zilberberg, Jigal Haas & Ravit Nahum. (2020) Stop GnRH-Agonist Combined With Multiple-Dose GnRH-Antagonist Protocol for Patients With “Genuine” Poor Response Undergoing Controlled Ovarian Hyperstimulation for IVF. Frontiers in Endocrinology 11.
Crossref
Bala Bhagavath. 2020. Diminished Ovarian Reserve and Assisted Reproductive Technologies. Diminished Ovarian Reserve and Assisted Reproductive Technologies 119 129 .
Thor Haahr, Carlos Dosouto, Carlo Alviggi, Sandro C. Esteves & Peter Humaidan. (2019) Management Strategies for POSEIDON Groups 3 and 4. Frontiers in Endocrinology 10.
Crossref

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