Advanced search
Publication Cover
Gynecological Endocrinology Volume 36, 2020 - Issue 5
Submit an article Journal homepage
332
Views
26
CrossRef citations to date
0
Altmetric
ENDOMETRIOSIS

PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage

Daniela MadanesLaboratorio de Inmunología de la Reproducción, Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Ciudad Autónoma de Buenos Aires, Argentina; View further author information
,
Mariela A. BilotasLaboratorio de Inmunología de la Reproducción, Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Ciudad Autónoma de Buenos Aires, Argentina; View further author information
,
Juan I. BastónLaboratorio de Fisiopatología Endometrial, Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Ciudad Autónoma de Buenos Aires, Argentina; View further author information
,
José J. SinglaHospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, ArgentinaView further author information
,
Gabriela F. MeresmanLaboratorio de Fisiopatología Endometrial, Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Ciudad Autónoma de Buenos Aires, Argentina; View further author information
,
Rosa I. BarañaoLaboratorio de Inmunología de la Reproducción, Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Ciudad Autónoma de Buenos Aires, Argentina; View further author information
&
Analía G. RicciLaboratorio de Inmunología de la Reproducción, Instituto de Biología y Medicina Experimental – Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Ciudad Autónoma de Buenos Aires, Argentina; Correspondence[email protected]
View further author information
 show all
Pages 436-440 | Received 25 Jun 2019, Accepted 11 Oct 2019, Published online: 22 Oct 2019

Citations (26)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Xinyue Zhou, Zhenyu Chen, Lipeng Pei & Jingli Sun. (2021) MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway. Bioengineered 12:1, pages 2203-2213.
Read now

Articles from other publishers (25)

Xiaoxiao Zhang, Shumiao Li, Zhenzhen Chen, Wei Liang, Shuting Pei, Feiyue Gou, Zhicheng Jia, Zhaoyang Geng & Xin Gong. (2023) Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway. Molecular Medicine Reports 28:5.
Crossref
Meichen Yin, Jianzhang Wang, Xue Ying, Zhou Fang & Xinmei Zhang. (2023) Long non coding RNA, C8orf49, a novel diagnostic and prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis by sponging miR-1323 in endometriosis. Molecular and Cellular Endocrinology 575, pages 112040.
Crossref
Tatiana S. Driva, Christoph Schatz & Johannes Haybaeck. (2023) Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis. Biomolecules 13:8, pages 1253.
Crossref
A. Marshall, K. F. Kommoss, H. Ortmann, M. Kirchner, J. Jauckus, P. Sinn, T. Strowitzki & A. Germeyer. (2023) Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways. Reproductive Biology and Endocrinology 21:1.
Crossref
Carla Noemí Olivares, Analía Gabriela Ricci, Mariela Andrea Bilotas, Laura Alaniz, Rosa Inés Barañao & Gabriela Fabiana Meresman. (2022) Effects of pharmacological inhibition of hyaluronic acid synthesis on experimental endometriosis. European Journal of Clinical Investigation 53:3.
Crossref
Yiran Gu, Zhiyun Ding, Qin Zhou, Juan Li & Wenyan Qian. (2023) JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis. Reproductive Biology 23:1, pages 100729.
Crossref
Rongyan Qin, Fengque Zheng, Weili Qin, Jiawei Wang, Nana Ma, Wencai Tian, Jiaxu Li, Ming Liao & Aiping Qin. (2023) Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis. Reproductive BioMedicine Online 46:3, pages 425-435.
Crossref
Mehran Dehghanian, Ghafour Yarahmadi, ReyhanehSadat Sandoghsaz, Ali Khodadadian, Farimah Shamsi & MohammadYahya Vahidi Mehrjardi. (2023) Evaluation of Rap1GAP and EPAC1 gene expression in endometriosis disease. Advanced Biomedical Research 12:1, pages 101.
Crossref
Chuanmei Zhong, Gongchenhao Ju, Sufang Yang, xiangpei Zhao, Jixiang Chen & Ning Li. (2023) Total Flavonoids of Polygala fallax Hemsl Induce Apoptosis of Human Ectopic Endometrial Stromal Cells through PI3K/AKT/Bcl-2 Signaling Pathway. Gynecologic and Obstetric Investigation 88:4, pages 197-213.
Crossref
Jeannette Rudzitis-Auth, Madeleine Becker, Claudia Scheuer, Michael D. Menger & Matthias W. Laschke. (2022) Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation. Nutrients 14:22, pages 4940.
Crossref
Junde Zhao, Juntao Wang, Jinxing Liu, Shuling Li, Pengfei Liu & Xiaodan Zhang. (2022) Effect and mechanisms of kaempferol against endometriosis based on network pharmacology and in vitro experiments. BMC Complementary Medicine and Therapies 22:1.
Crossref
Jixin Li, Yanan He, Tian Liang, Jing Wang, Xinyan Jiang & Guangmei Zhang. (2022) Identification of potential differentially methylated gene-related biomarkers in endometriosis. Epigenomics 14:19, pages 1157-1179.
Crossref
Yang Gao, Wenjing Ji, Man Lu, Zhiheng Wang, Xurui Jia, Dawei Wang, Peng Cao, Chunping Hu, Xiaoyan Sun & Zhigang Wang. (2022) Systemic pharmacological verification of Guizhi Fuling decoction in treating endometriosis-associated pain. Journal of Ethnopharmacology 297, pages 115540.
Crossref
Chih-Chieh Chen, Yung-Che Chou, Chia-Yi Hsu, Eing-Mei Tsai & Tze-Kiong Er. (2022) Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing. Biomedicines 10:10, pages 2432.
Crossref
Werner Maria Neuhausser, Emmanuelle Faure-Kumar, Swapna Mahurkar-Joshi, Dimitrios Iliopoulos & Denny Sakkas. (2022) Identification of miR-34-3p as a candidate follicular phase serum marker for endometriosis: a pilot study. F&S Science 3:3, pages 269-278.
Crossref
Nannan Kang, Huizhi Shan, Junxia Wang, Jie Mei, Yue Jiang, Jidong Zhou, Chenyang Huang, Hui Zhang, Mei Zhang, Xin Zhen, Guijun Yan & Haixiang Sun. (2022) Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1. Biology of Reproduction 106:6, pages 1112-1125.
Crossref
Warren B. Nothnick, Riley Peterson, Paige Minchella, Tommaso Falcone, Amanda Graham & Austin Findley. (2022) The Relationship and Expression of miR-451a, miR-25-3p and PTEN in Early Peritoneal Endometriotic Lesions and Their Modulation In Vitro. International Journal of Molecular Sciences 23:11, pages 5862.
Crossref
Chaohui Bao, Hengru Wang & Hai Fang. (2022) Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation. Frontiers in Immunology 13.
Crossref
Tatiana S. Driva, Christoph Schatz, Monika Sobočan & Johannes Haybaeck. (2022) The Role of mTOR and eIF Signaling in Benign Endometrial Diseases. International Journal of Molecular Sciences 23:7, pages 3416.
Crossref
Hang Zhang, Shufeng Li, Yongsheng Si & Haiwei Xu. (2021) Andrographolide and its derivatives: Current achievements and future perspectives. European Journal of Medicinal Chemistry 224, pages 113710.
Crossref
Bárbara Andrea Mc Cormack, Carla Noemí Olivares, Daniela Madanes, Analía Gabriela Ricci, Mariela Andrea Bilotas & Rosa Inés Barañao. (2021) Effect of urolithins A and B on ectopic endometrial growth in a murine model of endometriosis. Food & Function 12:20, pages 9894-9903.
Crossref
Zhongqi Cui, Ramesh Bhandari, Qin Lei, Mingzhi Lu, Lei Zhang, Mengmei Zhang, Fenyong Sun, Lijin Feng & Shasha Zhao. (2021) Identification and Exploration of Novel Macrophage M2-Related Biomarkers and Potential Therapeutic Agents in Endometriosis. Frontiers in Molecular Biosciences 8.
Crossref
O. A Melkozerova, E. O Okulova, A. A Mikhelson & T. B Tretyakova. (2021) The role of mutations in the PI3K/AKT/mTOR- signal pathway in decreasing ovarian reserve in reproductive patients with deep infiltrative endometriosis. Genes & Cells 16:2, pages 66-70.
Crossref
Tengyun Ma, Panwang Liu, Jiangping Wei, Meihuan Zhao, Xingxing Yao, Xiaohong Luo & Shijun Xu. (2021) Imperatorin alleviated endometriosis by inhibiting the activation of PI3K/Akt/NF-κB pathway in rats. Life Sciences 274, pages 119291.
Crossref
Mila Maidarti, Richard A. Anderson & Evelyn E. Telfer. (2020) Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing. Cells 9:1, pages 200.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.